ESR1

Functionⁱ

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	185 – 250	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	66
Zinc fingerⁱ	185 – 205	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	221 – 245	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen metabolic process Source: Ensembl
antral ovarian follicle growth Source: Ensembl
cellular response to estradiol stimulus Source: UniProtKB
cellular response to estrogen stimulus Source: Ensembl
epithelial cell development Source: Ensembl
epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
intracellular estrogen receptor signaling pathway Source: Ensembl
intracellular steroid hormone receptor signaling pathway Source: UniProtKB
male gonad development Source: Ensembl
mammary gland alveolus development Source: Ensembl
mammary gland branching involved in pregnancy Source: Ensembl
negative regulation of DNA-binding transcription factor activity Source: UniProtKB
negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
positive regulation of cytosolic calcium ion concentration Source: UniProtKB
positive regulation of DNA-binding transcription factor activity Source: UniProtKB
positive regulation of fibroblast proliferation Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: UniProtKB
positive regulation of nitric-oxide synthase activity Source: UniProtKB
positive regulation of phospholipase C activity Source: UniProtKB
positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
positive regulation of transcription, DNA-templated Source: UniProtKB
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
prostate epithelial cord elongation Source: Ensembl
protein localization to chromatin Source: Ensembl
regulation of apoptotic process Source: Ensembl
regulation of branching involved in prostate gland morphogenesis Source: Ensembl
regulation of inflammatory response Source: Ensembl
regulation of toll-like receptor signaling pathway Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
stem cell differentiation Source: Ensembl
uterus development Source: Ensembl
vagina development Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estrogen receptor Short name: ER Alternative name(s): ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1
Gene namesⁱ	Name:ESR1 Synonyms:ESR, NR3A1
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000314985 Componentⁱ: Chromosome 1 UP000008227 Componentⁱ: Chromosome 1

Organism-specific databases

VGNCⁱ	VGNC:103089, ESR1

VGNCⁱ

VGNC:103089, ESR1

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053622	1 – 595	Estrogen receptorAdd BLAST		595

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	104	Phosphoserine; by CDK2By similarity	1
Modified residueⁱ	106	Phosphoserine; by CDK2By similarity	1
Modified residueⁱ	118	PhosphoserineBy similarity	1
Modified residueⁱ	167	Phosphoserine; by CK2By similarity	1
Modified residueⁱ	260	Asymmetric dimethylarginine; by PRMT1By similarity	1
Lipidationⁱ	447	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	537	Phosphotyrosine; by Tyr-kinasesBy similarity	1

Post-translational modificationⁱ

Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity).By similarity

Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1.By similarity

Palmitoylated at Cys-447 by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor (By similarity).By similarity

Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.By similarity

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q29040
PRIDEⁱ	Q29040

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q29040, baseline and differential

ExpressionAtlasⁱ

Q29040, baseline and differential

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer. Can form a heterodimer with ESR2.

Interacts with coactivator NCOA5.

Interacts with NCOA7; the interaction is ligand-inducible.

Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, PELP1, SMARD1, and UBE1C.

Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription.

Interacts with DNTTIP2, and UIMC1.

Interacts with KMT2D/MLL2.

Interacts with ATAD2; the interaction is enhanced by estradiol.

Interacts with KIF18A and LDB1.

Interacts with RLIM (via its C-terminus).

Interacts with MACROD1.

Interacts with SH2D4A and PLCG.

Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation.

Interacts with DYNLL1.

Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes.

Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.

Interacts with DNAAF4.

Interacts with PRMT2.

Interacts with PI3KR1 or PIK3R2, SRC and PTK2/FAK1.

Interacts with RBFOX2.

Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1.

Interacts with CITED1; the interaction is estrogen-dependent.

Interacts with FAM120B, FOXL2, PHB2 and SLC30A9.

Interacts with coactivators NCOA3 and NCOA6.

Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D.

Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy.

Interacts with DDX5.

Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions.

Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3.

Interacts with NRIP1.

Interacts with GPER1; the interaction occurs in an estrogen-dependent manner.

Interacts with CLOCK and the interaction is stimulated by estrogen.

Interacts with TRIP4 (ufmylated); estrogen dependent.

Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.

Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.

Interacts with ZFHX3.

Interacts with SFR1 in a ligand-dependent and -independent manner.

Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation.

Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.

Interacts with ESRRB isoform 1.

Interacts with UBE3A and WBP2.

Interacts with GTF2B.

Interacts with RBM39. In the absence of hormonal ligand, interacts with TACC1 (By similarity).

By similarity

GO - Molecular functionⁱ

ATPase binding Source: Ensembl
beta-catenin binding Source: Ensembl
estrogen receptor binding Source: Ensembl
identical protein binding Source: Ensembl
protein kinase binding Source: Ensembl
RNA polymerase II transcription corepressor binding Source: Ensembl
TBP-class protein binding Source: Ensembl
TFIIB-class transcription factor binding Source: Ensembl
transcription coactivator binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000030835

STRINGⁱ

9823.ENSSSCP00000030835

Structureⁱ

3D structure databases

SMRⁱ	Q29040
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	311 – 547	NR LBDPROSITE-ProRule annotationAdd BLAST		237

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 184	Modulating (transactivation AF-1); mediates interaction with MACROD1By similarityAdd BLAST	184
Regionⁱ	35 – 174	Interaction with DDX5; self-associationBy similarityAdd BLAST	140
Regionⁱ	35 – 47	Required for interaction with NCOA1By similarityAdd BLAST	13
Regionⁱ	185 – 310	Mediates interaction with DNTTIP2By similarityAdd BLAST	126
Regionⁱ	251 – 310	HingeAdd BLAST	60
Regionⁱ	262 – 595	Interaction with AKAP13By similarityAdd BLAST	334
Regionⁱ	264 – 594	Self-associationBy similarityAdd BLAST	331
Regionⁱ	311 – 594	Transactivation AF-2By similarityAdd BLAST	284

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	64 – 70	Poly-Ala		7

Domainⁱ

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	185 – 205	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	221 – 245	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158133
InParanoidⁱ	Q29040
OMAⁱ	LHAPANF
Database of Orthologous Groups More...OrthoDBⁱ	487299at2759

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q29040-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQA NELEPLNRPQ LKIPLERPLG EVYVDSSKPA 
        60         70         80         90        100
VYNYPEGAAY DFNAAAAASA PVYGQSGLAY GPGSEAAAFG ANGLGGFQPL 
       110        120        130        140        150
NSVSPSPLVL LHPPPQLSPF LHPHGQQVPY YLENEPSGYA VREAGPPAFY 
       160        170        180        190        200
RPNSDNRRQG GRERLASTSD KGSMAMESAK ETRYCAVCND YASGYHYGVW 
       210        220        230        240        250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM 
       260        270        280        290        300
MKGGIRKDRR GGRMLKHKRQ RDDGEGRNEA VPPGDMRSAN LWPSPLLIKH 
       310        320        330        340        350
TKKNSPVLSL TADQMISALL EAEPPIIYSE YDPTRPLSEA SMMGLLTNLA 
       360        370        380        390        400
DRELVHMINW AKRVPGFLDL SLHDQVHLLE CAWLEILMIG LVWRSMEHPG 
       410        420        430        440        450
KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS 
       460        470        480        490        500
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ 
       510        520        530        540        550
HRRLAQLLLI LSHFRHMSNK GMEHLYNMKC KNVVPLYDLL LEMLDAHRLH 
       560        570        580        590 
APTNLGGPPP EDMSQSQLAT SGSTPSHSLQ MYYITGEAEN FPTTI

Length:595

Mass (Da):66,361

Last modified:November 1, 1997 - v1

Checksum:ⁱ0EC23DC3085BF001

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A5S8LAU6	A0A5S8LAU6_PIG	Estrogen receptor Estrogen receptor, ER (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	ESR1	574	Annotation score:
A0A5S6HFY3	A0A5S6HFY3_PIG	ER-alpha ER-alpha (Estradiol receptor) (Estrogen receptor) (Nuclear receptor subfamily 3 group A member 1)	ESR1	587	Annotation score:
A0A5G2RAX2	A0A5G2RAX2_PIG	ER-alpha ER-alpha (Estradiol receptor) (Estrogen receptor) (Nuclear receptor subfamily 3 group A member 1)	ESR1	334	Annotation score:
A0A288CG40	A0A288CG40_PIG	Estrogen receptor Estrogen receptor	ESR1	152	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z37167 mRNA Translation: CAA85524.1
PIRⁱ	I47140
NCBI Reference Sequences More...RefSeqⁱ	NP_999385.1, NM_214220.1

Genome annotation databases

Ensemblⁱ	ENSSSCT00000035147; ENSSSCP00000030835; ENSSSCG00000025777 ENSSSCT00025061031; ENSSSCP00025025914; ENSSSCG00025044932 ENSSSCT00030090594; ENSSSCP00030041735; ENSSSCG00030064727 ENSSSCT00040088178; ENSSSCP00040038757; ENSSSCG00040064377 ENSSSCT00045062399; ENSSSCP00045043938; ENSSSCG00045036259 ENSSSCT00050101315; ENSSSCP00050044055; ENSSSCG00050074040 ENSSSCT00055032656; ENSSSCP00055026013; ENSSSCG00055016487 ENSSSCT00060059864; ENSSSCP00060025649; ENSSSCG00060044136 ENSSSCT00065060029; ENSSSCP00065026019; ENSSSCG00065043873 ENSSSCT00070052480; ENSSSCP00070044420; ENSSSCG00070026203 ENSSSCT00070052481; ENSSSCP00070044421; ENSSSCG00070026203 ENSSSCT00070052482; ENSSSCP00070044422; ENSSSCG00070026203 ENSSSCT00070052483; ENSSSCP00070044423; ENSSSCG00070026203
GeneIDⁱ	397435
KEGGⁱ	ssc:397435

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q29040	Estrogen receptor		RAT		632	UniRef90_Q29040
Estrogen receptor		DIPOR		608
Estrogen receptor		RABIT		598
Estrogen receptor		MACMU		594
Estrogen receptor		RHIUN		573
+8

Protein	Similar proteins		Species	Score	Length	Source
Q29040	Estrogen receptor		MOUSE		599	UniRef50_P19785
Estrogen receptor		RAT		600
Estrogen receptor		MESAU		595
Estrogen receptor		CHICK		589
Estrogen receptor		TAEGU		587
+420

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z37167 mRNA Translation: CAA85524.1
PIRⁱ	I47140
RefSeqⁱ	NP_999385.1, NM_214220.1

3D structure databases

SMRⁱ	Q29040
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000030835

STRINGⁱ

9823.ENSSSCP00000030835

Proteomic databases

PaxDbⁱ	Q29040
PRIDEⁱ	Q29040

Genome annotation databases

Ensemblⁱ	ENSSSCT00000035147; ENSSSCP00000030835; ENSSSCG00000025777 ENSSSCT00025061031; ENSSSCP00025025914; ENSSSCG00025044932 ENSSSCT00030090594; ENSSSCP00030041735; ENSSSCG00030064727 ENSSSCT00040088178; ENSSSCP00040038757; ENSSSCG00040064377 ENSSSCT00045062399; ENSSSCP00045043938; ENSSSCG00045036259 ENSSSCT00050101315; ENSSSCP00050044055; ENSSSCG00050074040 ENSSSCT00055032656; ENSSSCP00055026013; ENSSSCG00055016487 ENSSSCT00060059864; ENSSSCP00060025649; ENSSSCG00060044136 ENSSSCT00065060029; ENSSSCP00065026019; ENSSSCG00065043873 ENSSSCT00070052480; ENSSSCP00070044420; ENSSSCG00070026203 ENSSSCT00070052481; ENSSSCP00070044421; ENSSSCG00070026203 ENSSSCT00070052482; ENSSSCP00070044422; ENSSSCG00070026203 ENSSSCT00070052483; ENSSSCP00070044423; ENSSSCG00070026203
GeneIDⁱ	397435
KEGGⁱ	ssc:397435

Organism-specific databases

CTDⁱ	2099
VGNCⁱ	VGNC:103089, ESR1

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
GeneTreeⁱ	ENSGT00940000158133
InParanoidⁱ	Q29040
OMAⁱ	LHAPANF
OrthoDBⁱ	487299at2759

Gene expression databases

ExpressionAtlasⁱ	Q29040, baseline and differential

ExpressionAtlasⁱ

Q29040, baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ESR1_PIG
Accessionⁱ	Q29040Primary (citable) accession number: Q29040
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	April 7, 2021
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q29040 (ESR1_PIG)

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Estrogen receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytoplasm and Cytosol

Plasma membrane

Nucleus

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ