UniProtKB - Q28GC2 (Q28GC2_XENTR)
Protein
Submitted name:
Catenin (Cadherin-associated protein), beta 1, 88kDa
Gene
ctnnb1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
GO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: GO_Central
- nuclear hormone receptor binding Source: GO_Central
- protein phosphatase binding Source: GO_Central
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- cell adhesion Source: InterPro
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
Reactomei | R-XTR-195253, Degradation of beta-catenin by the destruction complex R-XTR-196299, Beta-catenin phosphorylation cascade R-XTR-201681, TCF dependent signaling in response to WNT R-XTR-201722, Formation of the beta-catenin:TCF transactivating complex R-XTR-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-XTR-351906, Apoptotic cleavage of cell adhesion proteins R-XTR-3769402, Deactivation of the beta-catenin transactivating complex R-XTR-4086398, Ca2+ pathway R-XTR-418990, Adherens junctions interactions R-XTR-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-XTR-5218920, VEGFR2 mediated vascular permeability R-XTR-525793, Myogenesis R-XTR-5626467, RHO GTPases activate IQGAPs R-XTR-8853884, Transcriptional Regulation by VENTX R-XTR-8951430, RUNX3 regulates WNT signaling |
Names & Taxonomyi
Protein namesi | Submitted name: Catenin (Cadherin-associated protein), beta 1, 88kDaImported |
Gene namesi | Name:ctnnb1Imported ORF Names:TGas082a20.1-001Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Organism-specific databases
Xenbasei | XB-GENE-487200, ctnnb1 |
Subcellular locationi
Plasma Membrane
- catenin complex Source: GO_Central
Other locations
- adherens junction Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSXETG00000013848, Expressed in embryo and 16 other tissues |
Interactioni
GO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: GO_Central
- nuclear hormone receptor binding Source: GO_Central
- protein phosphatase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000030302 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 151 – 191 | ARMPROSITE-ProRule annotationAdd BLAST | 41 | |
Repeati | 193 – 236 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 235 – 277 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 277 – 319 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 319 – 362 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 400 – 442 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 442 – 484 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 489 – 532 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 594 – 636 | ARMPROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 56 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 730 – 781 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 48 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the beta-catenin family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
HOGENOMi | CLU_008757_1_1_1 |
OMAi | LLFYNDI |
OrthoDBi | 321213at2759 |
TreeFami | TF317997 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
i Sequence
Sequence statusi: Complete.
Q28GC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG
60 70 80 90 100
NPEDEDVDTN QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP
110 120 130 140 150
ETLDEGMQIP STQFDSAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT
160 170 180 190 200
RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR
210 220 230 240 250
TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS
260 270 280 290 300
VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
310 320 330 340 350
LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC
360 370 380 390 400
SSNKPAIVEA GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG
410 420 430 440 450
LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT
460 470 480 490 500
VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP
510 520 530 540 550
PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR
560 570 580 590 600
TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
610 620 630 640 650
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG
660 670 680 690 700
VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI
710 720 730 740 750
GAQGEPLGYR QDDPSYRSFH APGYGQDAMG MDSMMDHDMA GHHPGADYPV
760 770 780
DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135469 mRNA Translation: AAI35470.1 CR761449 mRNA Translation: CAJ81980.1 |
RefSeqi | NP_001016958.1, NM_001016958.1 |
Genome annotation databases
GeneIDi | 549712 |
KEGGi | xtr:549712 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135469 mRNA Translation: AAI35470.1 CR761449 mRNA Translation: CAJ81980.1 |
RefSeqi | NP_001016958.1, NM_001016958.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000030302 |
Protocols and materials databases
DNASUi | 549712 |
Genome annotation databases
GeneIDi | 549712 |
KEGGi | xtr:549712 |
Organism-specific databases
CTDi | 1499 |
Xenbasei | XB-GENE-487200, ctnnb1 |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
HOGENOMi | CLU_008757_1_1_1 |
OMAi | LLFYNDI |
OrthoDBi | 321213at2759 |
TreeFami | TF317997 |
Enzyme and pathway databases
Reactomei | R-XTR-195253, Degradation of beta-catenin by the destruction complex R-XTR-196299, Beta-catenin phosphorylation cascade R-XTR-201681, TCF dependent signaling in response to WNT R-XTR-201722, Formation of the beta-catenin:TCF transactivating complex R-XTR-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-XTR-351906, Apoptotic cleavage of cell adhesion proteins R-XTR-3769402, Deactivation of the beta-catenin transactivating complex R-XTR-4086398, Ca2+ pathway R-XTR-418990, Adherens junctions interactions R-XTR-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-XTR-5218920, VEGFR2 mediated vascular permeability R-XTR-525793, Myogenesis R-XTR-5626467, RHO GTPases activate IQGAPs R-XTR-8853884, Transcriptional Regulation by VENTX R-XTR-8951430, RUNX3 regulates WNT signaling |
Gene expression databases
Bgeei | ENSXETG00000013848, Expressed in embryo and 16 other tissues |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q28GC2_XENTR | |
Accessioni | Q28GC2Primary (citable) accession number: Q28GC2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 4, 2006 |
Last sequence update: | April 4, 2006 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |