UniProtKB - Q28GB8 (NODAL_XENTR)
Protein
Nodal homolog
Gene
nodal
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene cascade in the left lateral plate mesoderm (By similarity).By similarity
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- type I activin receptor binding Source: GO_Central
GO - Biological processi
- axial mesoderm formation Source: UniProtKB
- BMP signaling pathway Source: GO_Central
- determination of left/right symmetry Source: UniProtKB
- heart development Source: UniProtKB
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Names & Taxonomyi
Protein namesi | Recommended name: Nodal homologAlternative name(s): Nodal-related protein 1 |
Gene namesi | Name:nodalBy similarity Synonyms:nr1 ORF Names:TGas124h10.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-487169, nodal1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000273276 | 19 – 278 | Sequence analysisAdd BLAST | 260 | |
ChainiPRO_0000273277 | 279 – 403 | Nodal homologSequence analysisAdd BLAST | 125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 303 ↔ 369 | By similarity | ||
Disulfide bondi | 332 ↔ 400 | By similarity | ||
Disulfide bondi | 336 ↔ 402 | By similarity | ||
Glycosylationi | 341 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 366 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q28GB8 |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with, and is inhibited by cer1 and gdf10/bmp3b.
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- type I activin receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000019726 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Sequence analysis
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | Q28GB8 |
OrthoDBi | 1518399at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q28GB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFLTAVLCF GFACMVQGVP SWLESRIPLL GSSVASKHPS LLDGNRHHRD
60 70 80 90 100
MKYPFYMMQL YQNLVMANDT GLARGHNTAT KEYDTVLSLF AKRCMESEKR
110 120 130 140 150
WTLSFDMSAV SKSSELKLAE LRIQLPHIEM SHNVTVDVYH TRDGEENLYL
160 170 180 190 200
GSFEANPFST KGSPWKVFNV TRILQHYFKE GQDIKSEYLR TKDRAERGSG
210 220 230 240 250
MSSAEFLDSP GDSPQYNPHH TPLRRYLSTE GVMLVLFTKV KPSVNHIGFP
260 270 280 290 300
SLIKTAESSK YVDMEKASRM PGIRRHRRNK NEKHHLSMGS IPSRHVDNGK
310 320 330 340 350
PLCRRVDMIV NFEDIGWGNW IVYPKKYNAY RCEGACPIPL NETFKPTNHA
360 370 380 390 400
YMKSVVKLYQ PEKVECPLCV PIKMSPLSML YYEGDEVVLR HHQEMIVEEC
GCS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF7B5A8 | F7B5A8_XENTR | Nodal homolog 1 | nodal1 | 403 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR761456 mRNA Translation: CAJ82560.1 |
RefSeqi | NP_001016321.1, NM_001016321.2 |
Genome annotation databases
GeneIDi | 549075 |
KEGGi | xtr:549075 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR761456 mRNA Translation: CAJ82560.1 |
RefSeqi | NP_001016321.1, NM_001016321.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000019726 |
Proteomic databases
PaxDbi | Q28GB8 |
Genome annotation databases
GeneIDi | 549075 |
KEGGi | xtr:549075 |
Organism-specific databases
CTDi | 549075 |
Xenbasei | XB-GENE-487169, nodal1 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | Q28GB8 |
OrthoDBi | 1518399at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NODAL_XENTR | |
Accessioni | Q28GB8Primary (citable) accession number: Q28GB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | April 4, 2006 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families