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Protein

Aspartate aminotransferase, mitochondrial

Gene

got2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity).By similarity

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62Substrate; via amide nitrogenBy similarity1
Binding sitei159SubstrateBy similarity1
Binding sitei212SubstrateBy similarity1
Binding sitei404SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase, mitochondrial (EC:2.6.1.1, EC:2.6.1.7)
Short name:
mAspAT
Alternative name(s):
Glutamate oxaloacetate transaminase 2
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV
Transaminase A
Gene namesi
Name:got2
ORF Names:TGas123d19.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-998300 got2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionBy similarityAdd BLAST26
ChainiPRO_000032759827 – 427Aspartate aminotransferase, mitochondrialAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ28F67
PRIDEiQ28F67

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000034675

Structurei

3D structure databases

ProteinModelPortaliQ28F67
SMRiQ28F67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
HOGENOMiHOG000185898
HOVERGENiHBG000951
InParanoidiQ28F67
KOiK14455
OrthoDBiEOG091G06G3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28F67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKSRLLV GVARCQPCLA AVQGRASSWW SHVEMGPPDP ILGVTEAFKR
60 70 80 90 100
DTNSKKMNLG VGAYRDDNGK PYVLSSVRKA EAQLASKNLD KEYLPIGGLA
110 120 130 140 150
EFARASAQLA LGENCDAIQS GRFITVQTIS GTGSLRVGAN FLQRFYKYSR
160 170 180 190 200
DVYLPKPSWG NHTPIFRDAG LEVKGYRYYD PKTCGFDFTG ALDDISKIPE
210 220 230 240 250
QSIILFHACA HNPTGVDPKQ EQWKELAALI KSRRLFPFFD MAYQGFASGD
260 270 280 290 300
TNRDAWAVRH FIQEGINVVL SQSYAKNMGL YGERVGAFTV VCSDAEEAKR
310 320 330 340 350
VESQLKILIR PMYSNPPLNG ARIAAAILTQ PDLRKEWLQE VKGMANRIIS
360 370 380 390 400
MREQLVSNLK KEGSIHNWQH ISDQIGMFCF TGLRPEQVER LIKEFSIYMT
410 420
KDGRISVAGV TSANNGYLAH AIHQVTK
Length:427
Mass (Da):47,575
Last modified:April 4, 2006 - v1
Checksum:i240F95773AC1A12C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762138 mRNA Translation: CAJ83961.1
RefSeqiNP_001016933.1, NM_001016933.2
UniGeneiStr.1247

Genome annotation databases

GeneIDi549687
KEGGixtr:549687

Similar proteinsi

Entry informationi

Entry nameiAATM_XENTR
AccessioniPrimary (citable) accession number: Q28F67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 4, 2006
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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