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Protein
Submitted name:

Suppressor of cytokine signaling 5

Gene

socs5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-XTR-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Submitted name:
Suppressor of cytokine signaling 5Imported
Gene namesi
Name:socs5Imported
ORF Names:TNeu050n02.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-479593 socs5

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSXETG00000022744 Expressed in 13 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049206

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini380 – 475SH2InterPro annotationAdd BLAST96
Domaini470 – 519SOCS boxInterPro annotationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 266Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
KOiK04698
OMAiLARATIC
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q28DL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVEKMWNT FKYRCQNLFS HDDEANQNDT VDVNANRCLG GIDKNENASG
60 70 80 90 100
QSAMLSIGPL QQNITSELSP SSSSSRRNQN CVSEMPQLVE ISVERDNDSG
110 120 130 140 150
LSAGTRLARR DSYTRHAPWG GKKKHSCSTK TQNSFDPDKK ICRTRSGLQR
160 170 180 190 200
RERRHGANSV HDMETIGSRA VGSRSLRQRL NETVGLCFPI RTYNRPSKPL
210 220 230 240 250
FTNKRKIHLS ELMLEKCPFP PGSDLAQKWH LIKQHTAPVS PHSSFLETFD
260 270 280 290 300
QSVVSAEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QVNPVYKLGP
310 320 330 340 350
KLAPGMADIS GDVNAVCQGG CESEEDTTTL CLQSRRQKQR QFSGDSHTQI
360 370 380 390 400
TKQGAWKVHT QIDYIHCLVP DLIEIISNPC YWGVMDRYEA EALLEGRPEG
410 420 430 440 450
TFLLRDSAQE DYLFSVSFRR YNRSLHARIE QWNHNFSFDA HDPCVFHSST
460 470 480 490 500
VTGLLEHYKD PSSCMFFEPL LTVPLNRTFP FSLQYICRAV ICRSTTYDGI
510 520 530
DLLPLPSMLQ DFLKEYHYKQ KVRVRWLERE PIKSK
Length:535
Mass (Da):61,146
Last modified:April 4, 2006 - v1
Checksum:iD0BE6582BE7F08F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011701 Genomic DNA No translation available.
BC161341 mRNA Translation: AAI61341.1
CR855450 mRNA Translation: CAJ83263.1
RefSeqiNP_001016844.1, NM_001016844.2
XP_012818484.1, XM_012963030.2
UniGeneiStr.4500

Genome annotation databases

EnsembliENSXETT00000049206; ENSXETP00000049206; ENSXETG00000022744
GeneIDi549598
KEGGixtr:549598

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011701 Genomic DNA No translation available.
BC161341 mRNA Translation: AAI61341.1
CR855450 mRNA Translation: CAJ83263.1
RefSeqiNP_001016844.1, NM_001016844.2
XP_012818484.1, XM_012963030.2
UniGeneiStr.4500

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000049206; ENSXETP00000049206; ENSXETG00000022744
GeneIDi549598
KEGGixtr:549598

Organism-specific databases

CTDi9655
XenbaseiXB-GENE-479593 socs5

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
KOiK04698
OMAiLARATIC
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-XTR-8951664 Neddylation

Gene expression databases

BgeeiENSXETG00000022744 Expressed in 13 organ(s), highest expression level in embryo

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ28DL3_XENTR
AccessioniPrimary (citable) accession number: Q28DL3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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