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Entry version 74 (29 Sep 2021)
Sequence version 1 (04 Apr 2006)
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Protein

Leucine-rich PPR motif-containing protein, mitochondrial

Gene

lrpprc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in RNA metabolism in both nuclei and mitochondria. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. May be involved in transcription regulation. Binds single-stranded DNA (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich PPR motif-containing protein, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrpprc
ORF Names:TTpA007l07.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1014657, lrpprc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033861843 – 1391Leucine-rich PPR motif-containing protein, mitochondrialAdd BLAST1349

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28C74

PRoteomics IDEntifications database

More...
PRIDEi
Q28C74

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000060744

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati110 – 144PPR 1Add BLAST35
Repeati145 – 179PPR 2Add BLAST35
Repeati180 – 214PPR 3Add BLAST35
Repeati215 – 249PPR 4Add BLAST35
Repeati250 – 284PPR 5Add BLAST35
Repeati389 – 425PPR 6Add BLAST37
Repeati704 – 738PPR 7Add BLAST35
Repeati741 – 775PPR 8Add BLAST35
Repeati779 – 813PPR 9Add BLAST35
Repeati815 – 850PPR 10Add BLAST36
Repeati948 – 982PPR 11Add BLAST35
Repeati1028 – 1062PPR 12Add BLAST35
Repeati1063 – 1093PPR 13Add BLAST31
Repeati1100 – 1134PPR 14Add BLAST35
Repeati1310 – 1344PPR 15Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1118 – 1387RNA-bindingBy similarityAdd BLAST270

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4318, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28C74

Database of Orthologous Groups

More...
OrthoDBi
1344243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR033490, LRP130
IPR002885, Pentatricopeptide_repeat
IPR033443, PPR_long
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46669, PTHR46669, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01535, PPR, 3 hits
PF13812, PPR_3, 1 hit
PF17177, PPR_long, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00756, PPR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51375, PPR, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28C74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALLAGARF LLRPGLRALP APCVRLSPGQ GRYLNNTPGH FAIAAQQKGH
60 70 80 90 100
IHEEPVSAVR AKQAQQFDWA LNKLDSSVRR TGRITKTLLQ KIFHDVCRTG
110 120 130 140 150
YPSSNQALLL LRSCGSLLPE LQMSERTEMA HRIWEKLQEL GAVFDVSHYN
160 170 180 190 200
ALLKVYLQNE HKFSPTEYLA KMEAANVQPN RVTYQRLIAA YCNEGDIEGA
210 220 230 240 250
SKILGFMKNK DLPITEAVFN TLVTGHARAG DMENAKNILS VMRSAGIEPG
260 270 280 290 300
PETYVALLTA YAEKGDINNI KQTLENVEKN EGSLTDRDLM QVIWSLAKAG
310 320 330 340 350
YPQYVQDIVE RMRYDRGYIP DAMNLCLSLM TQGFEDVAFL VLKSFSAASH
360 370 380 390 400
DSPNGDSLHH GNFFLRHCVN LDKPANKVKQ FCDGLKEENL HSAPLQFALY
410 420 430 440 450
CSLDAKKADL ALELMKMMKQ EGMPVRPHYC WPLLISFQKE KNAEGTIKVI
460 470 480 490 500
KALSEIGVEL DVETYSNYVL SVFNDVKSAR AQLQEHGCTV DSSWFNLAEL
510 520 530 540 550
RHDAVSGNLE EVYSLLSSPS FPSVDLGHFR GSLITAFKRS NNVDLKAKIT
560 570 580 590 600
ELLYKDGRYC QAASGPNEAV GYFLYNLIDS MSDAEVQAKE EHLRQYFHQL
610 620 630 640 650
KNANIVISAN IYRGIRNLLD SSHVPELIKD VIVLVDSQET LTSSDIAKSA
660 670 680 690 700
ELKASTLEEE IETLKAENKP FGDVLKQLVM IHCSEENMQK ALEVKAKYEQ
710 720 730 740 750
ENLAIGTYAA LIQLCCRHDN PDEALNLKQE LNRKDSSAVL DTSKYLALVK
760 770 780 790 800
VFGKNGRIAD AINVLKEMKE KDVPLKETTT TSFFHILNAA ALRGDAETVD
810 820 830 840 850
KIHESIVTLG LAKPTSNLCS PLVSVHLEKG DLPAAMETLF TCSKKYNCMP
860 870 880 890 900
RLHDVLCRLV EKGDTDLLQK AMDHISQERG EMAMLYDLLF AFLHTGKYKE
910 920 930 940 950
ARKIIETPGL RARPGRLQWF AEKCIATNQM EALENLVDMT QKLFECDRDD
960 970 980 990 1000
MYYYLLKLCK ENDDWKKADS AWTKIQEENV IPRERTLRLL ADIFRRNGQE
1010 1020 1030 1040 1050
VPFDVPETWY KDAAESKVLA SSSAPSSPES SFQKRVQVLS KKNRAKDAYE
1060 1070 1080 1090 1100
AFMEGENNGT AMSASAYSSL IRSMLSEGML EEAKKVLNTA ENHIKGFTLN
1110 1120 1130 1140 1150
DAASSLLIIT QVRRDYLKDA LASLKAMLEG DKVPTQLAVT RLVQALALKG
1160 1170 1180 1190 1200
DLEGIEVVEN MMRNIGSSIR LSQMLFINNK MLAHLKRGKT EEAIELIEPL
1210 1220 1230 1240 1250
YTGTDSQVTS ISYVFRKAME EKMESALEKL SGMAERLANQ FAVYRPVTDL
1260 1270 1280 1290 1300
FLQYIQVGRK DDARFLLQRC GSIAEQTPVL VSFISRSAQI PGQAQLIKDL
1310 1320 1330 1340 1350
LELIPEFSER ETAYSYLMKC YATDKDATAA TALYEKMKSE SVSPDELFLK
1360 1370 1380 1390
RLAVLLREAG EPVPFSEPPE SFKFYADKLK KDKADSYDDE H
Length:1,391
Mass (Da):156,250
Last modified:April 4, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26245D6F7DEA4C9E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR942422 mRNA Translation: CAJ83132.1

NCBI Reference Sequences

More...
RefSeqi
NP_001039203.1, NM_001045738.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
734062

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:734062

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR942422 mRNA Translation: CAJ83132.1
RefSeqiNP_001039203.1, NM_001045738.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000060744

Proteomic databases

PaxDbiQ28C74
PRIDEiQ28C74

Genome annotation databases

GeneIDi734062
KEGGixtr:734062

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10128
XenbaseiXB-GENE-1014657, lrpprc

Phylogenomic databases

eggNOGiKOG4318, Eukaryota
InParanoidiQ28C74
OrthoDBi1344243at2759

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR033490, LRP130
IPR002885, Pentatricopeptide_repeat
IPR033443, PPR_long
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR46669, PTHR46669, 2 hits
PfamiView protein in Pfam
PF01535, PPR, 3 hits
PF13812, PPR_3, 1 hit
PF17177, PPR_long, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
TIGRFAMsiTIGR00756, PPR, 4 hits
PROSITEiView protein in PROSITE
PS51375, PPR, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPPRC_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28C74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 4, 2006
Last modified: September 29, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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