The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q28BT4 (CALU_XENTR)
Protein
Calumenin
Gene
calu
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 81 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 83 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 85 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 87 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 92 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 117 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 119 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 121 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 128 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 164 | Calcium 3Curated | 1 | |
Metal bindingi | 166 | Calcium 3Curated | 1 | |
Metal bindingi | 168 | Calcium 3Curated | 1 | |
Metal bindingi | 175 | Calcium 3Curated | 1 | |
Metal bindingi | 201 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 203 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 205 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 212 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 242 | Calcium 5Curated | 1 | |
Metal bindingi | 244 | Calcium 5Curated | 1 | |
Metal bindingi | 246 | Calcium 5Curated | 1 | |
Metal bindingi | 248 | Calcium 5Curated | 1 | |
Metal bindingi | 253 | Calcium 5Curated | 1 | |
Metal bindingi | 278 | Calcium 6Curated | 1 | |
Metal bindingi | 280 | Calcium 6Curated | 1 | |
Metal bindingi | 282 | Calcium 6Curated | 1 | |
Metal bindingi | 284 | Calcium 6Curated | 1 | |
Metal bindingi | 289 | Calcium 6Curated | 1 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-XTR-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Calumenin |
Gene namesi | Name:calu ORF Names:TNeu055n17.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-1007422, calu |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- Melanosome By similarity
- Sarcoplasmic reticulum lumen By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000364198 | 20 – 315 | CalumeninAdd BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q28BT4 |
Interactioni
Subunit structurei
Interacts with ggcx.
By similarityStructurei
3D structure databases
AlphaFoldDBi | Q28BT4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 103 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 104 – 139 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 151 – 186 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 188 – 223 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 229 – 264 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 265 – 300 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 312 – 315 | Prevents secretion from ERBy similarity | 4 |
Sequence similaritiesi
Belongs to the CREC family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG4223, Eukaryota |
GeneTreei | ENSGT01010000222360 |
InParanoidi | Q28BT4 |
OMAi | VKTWIIP |
OrthoDBi | 909079at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q28BT4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTRRLLLCL CLWVACVVSK PTEKKDRVHH DPQLSEKVHD DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKT FDQLTPEESK ERLGMIVSKI DLDNDGYVTE GELTAWIKKA
110 120 130 140 150
QKKYVYDNVE RQWQEFDLNQ DGLVSWDEYR NVTYGTYLDD PDPDNSFNYK
160 170 180 190 200
QMMVRDERRF KMADQDGDLI ATKEEFTAFL HPEEFDYMKD IVVLETMEDI
210 220 230 240 250
DKNGDGLIDL EEYIGDMYNH DGDANEPEWV KTEREQFVEF RDKNHDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAES RHLVYESDQN KDSKLTREEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG1K3K8 | G1K3K8_XENTR | Adenylyl cyclase-associated protein | cap2 calu | 483 | Annotation score: | ||
A0A8J0QKE8 | A0A8J0QKE8_XENTR | calumenin precursor | calu crocalbin | 315 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR942649 mRNA Translation: CAJ82342.1 |
RefSeqi | XP_012814244.1, XM_012958790.2 |
Genome annotation databases
Ensembli | ENSXETT00000049856; ENSXETP00000049856; ENSXETG00000023059 |
GeneIDi | 407965 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR942649 mRNA Translation: CAJ82342.1 |
RefSeqi | XP_012814244.1, XM_012958790.2 |
3D structure databases
AlphaFoldDBi | Q28BT4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | Q28BT4 |
Genome annotation databases
Ensembli | ENSXETT00000049856; ENSXETP00000049856; ENSXETG00000023059 |
GeneIDi | 407965 |
Organism-specific databases
CTDi | 813 |
Xenbasei | XB-GENE-1007422, calu |
Phylogenomic databases
eggNOGi | KOG4223, Eukaryota |
GeneTreei | ENSGT01010000222360 |
InParanoidi | Q28BT4 |
OMAi | VKTWIIP |
OrthoDBi | 909079at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-XTR-8957275, Post-translational protein phosphorylation |
Family and domain databases
InterProi | View protein in InterPro IPR027239, Calumenin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR10827:SF76, PTHR10827:SF76, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CALU_XENTR | |
Accessioni | Q28BT4Primary (citable) accession number: Q28BT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | April 4, 2006 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families