UniProtKB - Q28BL6 (AACS_XENTR)
Protein
Acetoacetyl-CoA synthetase
Gene
aacs
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Activates acetoacetate to acetoacetyl-CoA.By similarity
Catalytic activityi
- EC:6.2.1.16
GO - Molecular functioni
- acetoacetate-CoA ligase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB-KW
- positive regulation of insulin secretion Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-XTR-77111, Synthesis of Ketone Bodies |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:aacs ORF Names:TEgg036g05.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-490085, aacs |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315790 | 1 – 672 | Acetoacetyl-CoA synthetaseAdd BLAST | 672 |
Proteomic databases
PaxDbi | Q28BL6 |
PRIDEi | Q28BL6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
InParanoidi | Q28BL6 |
OrthoDBi | 899666at2759 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q28BL6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKGELMEE IMEAKVMWYP DSKKITQMDQ FRNRVNRNLG LRLANYNELY
60 70 80 90 100
QWSVEFYPEF WAEFWDFSGI VYSKTYDEVI DRSKGIADVP EWFKGSRLNY
110 120 130 140 150
AENLLKHKEN DKIALYSARE GKENIEKVTF AELRRDVALF AAAMRKMGIK
160 170 180 190 200
TGDRVAGYLP NCIQTVEAML AAASIGAIWS ATSPDFGVNG VLDRFSQIQP
210 220 230 240 250
KLILSVESVI YNGKEHCHLE KLQHVVKGLP DLKKVVVIPY VLPKEKIDIS
260 270 280 290 300
KIPNSMFLDE FLATGKVGDQ SPQLEFEQLP FNHPLYIMYS SGTTGAPKCM
310 320 330 340 350
VHSAGGTLIK HLTEHILHGS TTSSDVIMYY TTAGWMMWNW LITAVATGAS
360 370 380 390 400
LVLYDGSPLV PSLNVLWDLV DRLGITILGT GAKWLAVLED KGLKPCNTHS
410 420 430 440 450
LQTLHTILST GSPLKPQSYE YVYKHIKSNV LLGSVSGGTD IIACFMGQNV
460 470 480 490 500
SVPVYKGEIQ ARHLGMAIEA WNEEGEAVLG ESGELVCLKP LPSQPTHFWN
510 520 530 540 550
DENGSKYQKA YFAKFPGVWA HGDYCKINPK TGGIVMLGRS DGTLNPNGVR
560 570 580 590 600
FGSSEIYNIV EAFVEVSDSL CVPQYNKDGD ERVILFLKMA DKFEFSKELL
610 620 630 640 650
KRIKDAIRVA LSARHVPALI LETKDIPYTI SGKKVEVAVK QVIAGKEVPH
660 670
RGAFSNPQSL DLYRNIPELQ NF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8PXJ6 | A0A6I8PXJ6_XENTR | Acetoacetyl-CoA synthetase | aacs | 727 | Annotation score: | ||
F7BUV3 | F7BUV3_XENTR | Acetoacetyl-CoA synthetase | aacs | 656 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR942772 mRNA Translation: CAJ81897.1 |
RefSeqi | NP_001039244.1, NM_001045779.1 |
Genome annotation databases
GeneIDi | 734109 |
KEGGi | xtr:734109 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR942772 mRNA Translation: CAJ81897.1 |
RefSeqi | NP_001039244.1, NM_001045779.1 |
3D structure databases
SMRi | Q28BL6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000060617 |
Proteomic databases
PaxDbi | Q28BL6 |
PRIDEi | Q28BL6 |
Genome annotation databases
GeneIDi | 734109 |
KEGGi | xtr:734109 |
Organism-specific databases
CTDi | 65985 |
Xenbasei | XB-GENE-490085, aacs |
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
InParanoidi | Q28BL6 |
OrthoDBi | 899666at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-77111, Synthesis of Ketone Bodies |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AACS_XENTR | |
Accessioni | Q28BL6Primary (citable) accession number: Q28BL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | April 4, 2006 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families