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Protein

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • fibronectin binding Source: GO_Central
  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:IGFBP5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001438720 – 271Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Modified residuei115PhosphoserineBy similarity1
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ28985
PRIDEiQ28985

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028711

Structurei

3D structure databases

ProteinModelPortaliQ28985
SMRiQ28985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiQ28985

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28985-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLTAVLLLL AACAGPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYREQAK IERDSREHEE PTTSEMAEET YSPKIFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVILAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
ELKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHSFDSSNV E
Length:271
Mass (Da):30,337
Last modified:February 16, 2004 - v2
Checksum:i7486EAF2BC7AF62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41340 mRNA Translation: AAA87859.2
PIRiJC4584
RefSeqiNP_999264.1, NM_214099.1
UniGeneiSsc.15800
Ssc.94196

Genome annotation databases

GeneIDi397182
KEGGissc:397182

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41340 mRNA Translation: AAA87859.2
PIRiJC4584
RefSeqiNP_999264.1, NM_214099.1
UniGeneiSsc.15800
Ssc.94196

3D structure databases

ProteinModelPortaliQ28985
SMRiQ28985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028711

Protein family/group databases

MEROPSiI31.952

Proteomic databases

PaxDbiQ28985
PRIDEiQ28985

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397182
KEGGissc:397182

Organism-specific databases

CTDi3488

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiQ28985

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP5_PIG
AccessioniPrimary (citable) accession number: Q28985
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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