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Entry version 127 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Zonadhesin

Gene

ZAN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zonadhesin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZAN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 2418ExtracellularSequence analysisAdd BLAST2389
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2419 – 2439HelicalSequence analysisAdd BLAST21
Topological domaini2440 – 2476CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000778530 – 2476ZonadhesinAdd BLAST2447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi735N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi758N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi833N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1448N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1544N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2359N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2370 ↔ 2381By similarity
Disulfide bondi2375 ↔ 2390By similarity
Disulfide bondi2392 ↔ 2401By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The MAM domains and the mucin-like domains are missing from the zonadhesin that binds to the egg extracellular matrix. Processing might occur during sperm maturation and/or capacitation.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28983

PeptideAtlas

More...
PeptideAtlasi
Q28983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In testis, primarily in haploid spermatids. Not in lung, liver, heart, spleen, brain, kidney, epididymis.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably forms covalent oligomers.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000008195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 144MAM 1PROSITE-ProRule annotationAdd BLAST114
Domaini147 – 312MAM 2PROSITE-ProRule annotationAdd BLAST166
Domaini690 – 739TIL 1Add BLAST50
Domaini740 – 794VWFC 1Add BLAST55
Domaini800 – 1015VWFD 1PROSITE-ProRule annotationAdd BLAST216
Domaini1070 – 1123TIL 2Add BLAST54
Domaini1124 – 1180VWFC 2Add BLAST57
Domaini1185 – 1402VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini1456 – 1511TIL 3Add BLAST56
Domaini1512 – 1568VWFC 3Add BLAST57
Domaini1574 – 1784VWFD 3PROSITE-ProRule annotationAdd BLAST211
Domaini1851 – 1907TIL 4Add BLAST57
Domaini1908 – 1963VWFC 4Add BLAST56
Domaini1969 – 2172VWFD 4PROSITE-ProRule annotationAdd BLAST204
Domaini2257 – 2310TIL 5Add BLAST54
Domaini2311 – 2365VWFC 5Add BLAST55
Domaini2366 – 2402EGF-likePROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 68753 X approximate heptapeptide repeats (mucin-like domain)Add BLAST369

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MAM domains probably mediate sperm adhesion to the zona pellucida.
During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
The VWFD domains 2 and 3 may mediate covalent oligomerization (By similarity to human intestinal mucin MUC2).

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28983

Database of Orthologous Groups

More...
OrthoDBi
22053at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263, MAM, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000998, MAM_dom
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 4 hits
PF00008, EGF, 1 hit
PF00629, MAM, 2 hits
PF01826, TIL, 5 hits
PF12714, TILa, 5 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00181, EGF, 4 hits
SM00137, MAM, 1 hit
SM00214, VWC, 2 hits
SM00215, VWC_out, 3 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 2 hits
SSF57567, SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 2 hits
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLPALAGP MAMPHPPLIP STPTLLAFSF PGGFYMLLDP KNAKPRQRSA
60 70 80 90 100
LLSPLIQSSG CLSLSFQYTQ RGQASGATLM VYASVLGSIR KHTLFSGQPG
110 120 130 140 150
PSWQPVSVNY TSQGQIQFTL VGVFGKIPEP AVAVDAISIA PCEESFPQCD
160 170 180 190 200
FEDNAHPFCD WVQASQDGGY WRQGNKNTFI QPAGPFGISL NGEGHYIFLE
210 220 230 240 250
TDKFSQAGQS FRLVSRPFCA PAVICVTFTY HMYGLGQGTK LRLLLGSPAG
260 270 280 290 300
SPPSSLWERV GPQSPEWLNT SVTIPSGHQQ PMQLIFEAVR GTNTAFVVAL
310 320 330 340 350
GFVLINHGTC RGPSETSVST EKPVAPTEKP TVPSEIYTIP TEKPMVHMEK
360 370 380 390 400
PIVHTEKPTV PTEKPTIPTE KSTVPTKKPT VFKEPTLPPE GPTVPAERPT
410 420 430 440 450
TPPEGPAVPP KGPTVLTEWP TSHTEKSTVH TEKPILPTGK STIPTEKPMV
460 470 480 490 500
PTKRTTTPTE RTTIPAEKPT VPIEKPMVPT ERTTIPTERT TIPTEKPTVP
510 520 530 540 550
TEKLTVPTEK PIVPTEKPIV PTEKHTIPTE KLTVLTERTT TPTERTTIPT
560 570 580 590 600
EKPTVPTEKP SVPTEKPTVP TEEPTIPTEK LTVPTERTTT PTKRTTTPTI
610 620 630 640 650
RTTTPTIRTT TPTERTTTPT IRTTTPTERT TIPTKKTTVP TEKTIIPTER
660 670 680 690 700
TIAPTTPQPS PTLVPTQPAA VVMPSTSATT VTPRTTIASC PPNAHFERCA
710 720 730 740 750
CPVSCQSPTP NCELFCKPGC VCDPGFLFSG SHCVNASSCD CFYNDNYYKL
760 770 780 790 800
GTDWFSPNCT EHCHCRPSSR MECQTFKCGT HTVCQLKNGQ YGCHPYGSAT
810 820 830 840 850
CSVYGDPHYL TFDGRRFNFM GKCTYILAQP CGNLTEHFFR VLVKKEERGQ
860 870 880 890 900
EGVSCLSKVY VTLPESTVTL LKGRHTLVGG QRVTLPAIPS RGVFLAPSGR
910 920 930 940 950
FVELQTAFGL RVRWDGDQQL FVSVPSTFSG KLCGLCGDYD GDSSNDNQKP
960 970 980 990 1000
DGSPAKDEKE LGSSWQTSED ADQQCEENQV SPPSCNTALQ NTMSGPEFCG
1010 1020 1030 1040 1050
QLVAPHGVFE ACLPHLRASS FFKSCTFDMC NFQGLQHMLC AHMSALTENC
1060 1070 1080 1090 1100
QDAGYTVKPW RGPQFCPLAC PRNSRYTLCA RLCPDTCHSE FSGRACKDRC
1110 1120 1130 1140 1150
VEGCECDPGF VLSGLQCVSR SECGCLDSTA GYVKVGERWF KPGCRQLCIC
1160 1170 1180 1190 1200
EGNNRTRCVL WRCQAQEFCG QQDGIYGCHA QGSATCTVSG DPHYLTFDGA
1210 1220 1230 1240 1250
LHHFTGTCTY TLTKPCWLRS LENSFLVSAT NEFRGGNLEA SYVRAVQVQV
1260 1270 1280 1290 1300
FNLRISLIKG RKVTLDGRRV ALPLWPAQGR VSITSSGSFI LLYTDFGLQV
1310 1320 1330 1340 1350
RYDGDHLVEV TVPSSYAGRL CGLCGNYNNN SLDDILQPDK RPASSSVRLG
1360 1370 1380 1390 1400
ASWKINELSE PGCFAEGGKP PRCLGKEVAD AWRKNCDVLM NPQGPFSQCH
1410 1420 1430 1440 1450
RVVAPQSSFS SCLYGQCATK GDTLTLCRSL QAYASLCARA GQALTWRNGT
1460 1470 1480 1490 1500
FCPLKCPSGS SYSTCANPCP ATCLSLNNPS YCPSTLPCAE GCECQKGHIL
1510 1520 1530 1540 1550
SGTSCVPLSQ CGCTTQRGSY HPVGESWYTD NSCSRLCTCS AHNNISCRQA
1560 1570 1580 1590 1600
SCKPSQMCWP QDGLIRCRVA GMGVCRIPDT SHYVSFDGSY HAVRGNCTYV
1610 1620 1630 1640 1650
LVKICHSTMD LPFFKISGEN GKREGQPPAF YLRQVYVDIF NTLVTLKQDQ
1660 1670 1680 1690 1700
VLINGTRVSL PATTQIRGVR VISRDGYTVL TINIGVQVKF DGRGFLEVEI
1710 1720 1730 1740 1750
PKAYYGRTCG VCGNFNDEEE DELMMPSDAL ALDDVMYVDS WRDKEIDPNC
1760 1770 1780 1790 1800
QEDDRKTEAE SQEQPSANCR PADLERAQEQ CQAAFQAPAW ANCATRVVLS
1810 1820 1830 1840 1850
PYVRSCTHKL CEFGGLNRAF CESLQAFGAA CQAQGIKPPV WRNSSFCPLD
1860 1870 1880 1890 1900
CSAHSVYTSC VPSCLPSCQD PEGQCTGAGA PSTCEEGCIC EPGYVLSEQQ
1910 1920 1930 1940 1950
CVARSQCGCR DARGTFLPVG RFRLSSGCSQ MCVCTAGAIE CRPFTCPSGS
1960 1970 1980 1990 2000
QCEPNEDGKD FCQPNSSNLC SVFGDPHYRT FDGLSYRFQG RMTYTLVKTL
2010 2020 2030 2040 2050
DVLPDGVEPL VVEGRNKVYP SLTPVFLQEI IVMVYGYTVQ LQAELELVVN
2060 2070 2080 2090 2100
GQKVSIPYKP NEYLQVTLRG RRLYLVTDFE LVVSFNGRNN AVIAMPSTYL
2110 2120 2130 2140 2150
GLVRGLCGNY DKNKRNDFML PNGSFTQNLL VFGNSWEVKA KEGHPRFSRA
2160 2170 2180 2190 2200
IREEEEKNEE SGFQNVSECS PEQLELVNHT QACGVLVDPQ GPFAACHQIV
2210 2220 2230 2240 2250
APGPFQEHCV FDLCAAPGPK EQEELRCQVL SGYAIICQES GPTLAGWRDH
2260 2270 2280 2290 2300
THCALPCPAN TVYQSCMTPC PASCATLAVP RACDGPCVEG CASLPGYIYS
2310 2320 2330 2340 2350
GAQSLPMAHC GCTNNGVYYQ QGDSFVTENC SQRCTCASSG VLLCEPLSCR
2360 2370 2380 2390 2400
PGEICTLGNL TRGCFRDSPC LQNPCQNDGR CREQGTHFTC ECELGYGGDL
2410 2420 2430 2440 2450
CTEPRGVPSP KKPEASNRVA ILLGMLMPTV LLVPAVTRVS RKRRRRRRPS
2460 2470
RERTQSQNRG KRAGTDCAPE QAYKVA
Length:2,476
Mass (Da):270,365
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA13B690375A6548C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti823C → V AA sequence (PubMed:7592795).Curated1
Sequence conflicti923S → Y AA sequence (PubMed:7592795).Curated1
Sequence conflicti965W → Y AA sequence (PubMed:7592795).Curated1
Sequence conflicti1241S → K AA sequence (PubMed:7592795).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U40024 mRNA Translation: AAC48486.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T34022

NCBI Reference Sequences

More...
RefSeqi
NP_999548.1, NM_214383.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397676

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40024 mRNA Translation: AAC48486.1
PIRiT34022
RefSeqiNP_999548.1, NM_214383.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008195

Proteomic databases

PaxDbiQ28983
PeptideAtlasiQ28983

Genome annotation databases

GeneIDi397676
KEGGissc:397676

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7455

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
InParanoidiQ28983
OrthoDBi22053at2759

Family and domain databases

CDDicd06263, MAM, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000998, MAM_dom
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF08742, C8, 4 hits
PF00008, EGF, 1 hit
PF00629, MAM, 2 hits
PF01826, TIL, 5 hits
PF12714, TILa, 5 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00181, EGF, 4 hits
SM00137, MAM, 1 hit
SM00214, VWC, 2 hits
SM00215, VWC_out, 3 hits
SM00216, VWD, 4 hits
SUPFAMiSSF49899, SSF49899, 2 hits
SSF57567, SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 2 hits
PS51233, VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZAN_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28983
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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