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Protein

Interleukin-12 subunit beta

Gene

IL12B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.By similarity
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-SSC-9020591 Interleukin-12 signaling
R-SSC-9020933 Interleukin-23 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit beta
Short name:
IL-12B
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunit
Short name:
CLMF p40
IL-12 subunit p40
Gene namesi
Name:IL12B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001093523 – 324Interleukin-12 subunit betaAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 90PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195Interchain (with C-99 in IL12A)PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28938
PRIDEiQ28938

Expressioni

Gene expression databases

GenevisibleiQ28938 SS

Interactioni

Subunit structurei

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018057

Structurei

3D structure databases

ProteinModelPortaliQ28938
SMRiQ28938
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 106Ig-like C2-typeAdd BLAST84
Domaini233 – 324Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IF5K Eukaryota
ENOG410YWXR LUCA
GeneTreeiENSGT00390000012630
HOGENOMiHOG000113027
HOVERGENiHBG052094
InParanoidiQ28938
KOiK05425
OMAiCEAKNYS
OrthoDBiEOG091G0EKV
TreeFamiTF334829

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003598 Ig_sub2
IPR015528 IL-12_beta
IPR019482 IL-12_beta_cen-dom
PANTHERiPTHR44982 PTHR44982, 1 hit
PfamiView protein in Pfam
PF10420 IL12p40_C, 1 hit
PIRSFiPIRSF038007 IL_12_beta, 1 hit
PRINTSiPR01928 INTRLEUKN12B
SMARTiView protein in SMART
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28938-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLQQLVVSW FSLVWLASPI VAIWELEKNV YVVELDWYPN APGEMVVLTC
60 70 80 90 100
NTPEEDGITW TSDQSSEVLG TGKTLTIHVK EFGDAGQYTC RKGGAVLSQS
110 120 130 140 150
LLLLHKKEDG IWSTDILKDQ KEPKNKSFLK CEAKNYSGRF TCWWLTAIST
160 170 180 190 200
DLKFSVKSSR GSTDPRGVTC GTATLSEDLG EYKKYRVECQ EGSACPAAEE
210 220 230 240 250
SLPIEVVLEA VHKLKYENYT SSFFIRDIIK PDPPKNLQLN PLKNSRHVEI
260 270 280 290 300
SWEYPDTWST PHSYFSLMFG VQVQGKNKRE KKDKLFTDQI SAKVTCHKDA
310 320
NIRVQARDRY YSSSWSEWAS VSCN
Length:324
Mass (Da):36,829
Last modified:November 1, 1996 - v1
Checksum:iF0E48B72F700086C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08317 mRNA Translation: AAA75356.1
RefSeqiNP_999178.1, NM_214013.1
UniGeneiSsc.71

Genome annotation databases

EnsembliENSSSCT00000018557; ENSSSCP00000018057; ENSSSCG00000017044
ENSSSCT00000037637; ENSSSCP00000045805; ENSSSCG00000017044
GeneIDi397076
KEGGissc:397076

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08317 mRNA Translation: AAA75356.1
RefSeqiNP_999178.1, NM_214013.1
UniGeneiSsc.71

3D structure databases

ProteinModelPortaliQ28938
SMRiQ28938
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018057

Proteomic databases

PaxDbiQ28938
PRIDEiQ28938

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018557; ENSSSCP00000018057; ENSSSCG00000017044
ENSSSCT00000037637; ENSSSCP00000045805; ENSSSCG00000017044
GeneIDi397076
KEGGissc:397076

Organism-specific databases

CTDi3593

Phylogenomic databases

eggNOGiENOG410IF5K Eukaryota
ENOG410YWXR LUCA
GeneTreeiENSGT00390000012630
HOGENOMiHOG000113027
HOVERGENiHBG052094
InParanoidiQ28938
KOiK05425
OMAiCEAKNYS
OrthoDBiEOG091G0EKV
TreeFamiTF334829

Enzyme and pathway databases

ReactomeiR-SSC-9020591 Interleukin-12 signaling
R-SSC-9020933 Interleukin-23 signaling

Gene expression databases

GenevisibleiQ28938 SS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003598 Ig_sub2
IPR015528 IL-12_beta
IPR019482 IL-12_beta_cen-dom
PANTHERiPTHR44982 PTHR44982, 1 hit
PfamiView protein in Pfam
PF10420 IL12p40_C, 1 hit
PIRSFiPIRSF038007 IL_12_beta, 1 hit
PRINTSiPR01928 INTRLEUKN12B
SMARTiView protein in SMART
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL12B_PIG
AccessioniPrimary (citable) accession number: Q28938
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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