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Protein

Insulin-like growth factor-binding protein 4

Gene

IGFBP4

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
Gene namesi
Name:IGFBP4
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001527741 – 237Insulin-like growth factor-binding protein 4Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 32PROSITE-ProRule annotation
Disulfide bondi9 ↔ 34PROSITE-ProRule annotation
Disulfide bondi17 ↔ 38PROSITE-ProRule annotation
Disulfide bondi23 ↔ 35PROSITE-ProRule annotation
Disulfide bondi46 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 79PROSITE-ProRule annotation
Glycosylationi104N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi110 ↔ 117PROSITE-ProRule annotation
Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
Disulfide bondi194 ↔ 205PROSITE-ProRule annotation
Disulfide bondi207 ↔ 228PROSITE-ProRule annotation
Modified residuei234PhosphoserineBy similarity1

Post-translational modificationi

There are two different molecular mass variants (29 kDa and 24 kDa forms). The 29 kDa form was shown to be N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

PTM databases

iPTMnetiQ28893

Expressioni

Tissue specificityi

Detected in adult ewe, liver > kidney > lung >> heart and also in several fetal tissues.1 Publication

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ28893
SMRiQ28893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini150 – 228Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

HOVERGENiHBG002631

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GKGMPCGVYT
60 70 80 90 100
PDCGSGLRCH PPRGVEKPLH TLVHGQGVCM ELAEIEAIQE SLQPSDKDEG
110 120 130 140 150
DHPNNSFSPC SAHDRKCLQK HLAKIRDRST SGGKMKVIGA PREEVRPVPQ
160 170 180 190 200
GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG
210 220 230
QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
Length:237
Mass (Da):25,869
Last modified:November 1, 1997 - v1
Checksum:iEBC80D4C7667A226
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77394 mRNA Translation: AAB33382.1
PIRiI47031
UniGeneiOar.518

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77394 mRNA Translation: AAB33382.1
PIRiI47031
UniGeneiOar.518

3D structure databases

ProteinModelPortaliQ28893
SMRiQ28893
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI31.952

PTM databases

iPTMnetiQ28893

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG002631

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP4_SHEEP
AccessioniPrimary (citable) accession number: Q28893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 20, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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