UniProtKB - Q28893 (IBP4_SHEEP)
Protein
Insulin-like growth factor-binding protein 4
Gene
IGFBP4
Organism
Ovis aries (Sheep)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Keywordsi
Molecular function | Growth factor binding |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:IGFBP4 |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000152774 | 1 – 237 | Insulin-like growth factor-binding protein 4Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 6 ↔ 32 | PROSITE-ProRule annotation | ||
Disulfide bondi | 9 ↔ 34 | PROSITE-ProRule annotation | ||
Disulfide bondi | 17 ↔ 38 | PROSITE-ProRule annotation | ||
Disulfide bondi | 23 ↔ 35 | PROSITE-ProRule annotation | ||
Disulfide bondi | 46 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 53 ↔ 79 | PROSITE-ProRule annotation | ||
Glycosylationi | 104 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 110 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 153 ↔ 183 | PROSITE-ProRule annotation | ||
Disulfide bondi | 194 ↔ 205 | PROSITE-ProRule annotation | ||
Disulfide bondi | 207 ↔ 228 | PROSITE-ProRule annotation | ||
Modified residuei | 234 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
There are two different molecular mass variants (29 kDa and 24 kDa forms). The 29 kDa form was shown to be N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinPTM databases
iPTMneti | Q28893 |
Expressioni
Tissue specificityi
Detected in adult ewe, liver > kidney > lung >> heart and also in several fetal tissues.1 Publication
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
By similarityGO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000015663 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 82 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 150 – 228 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
OMAi | GLCMELA |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q28893-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GKGMPCGVYT
60 70 80 90 100
PDCGSGLRCH PPRGVEKPLH TLVHGQGVCM ELAEIEAIQE SLQPSDKDEG
110 120 130 140 150
DHPNNSFSPC SAHDRKCLQK HLAKIRDRST SGGKMKVIGA PREEVRPVPQ
160 170 180 190 200
GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG
210 220 230
QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S77394 mRNA Translation: AAB33382.1 |
PIRi | I47031 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S77394 mRNA Translation: AAB33382.1 |
PIRi | I47031 |
3D structure databases
SMRi | Q28893 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000015663 |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
iPTMneti | Q28893 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
OMAi | GLCMELA |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_SHEEP | |
Accessioni | Q28893Primary (citable) accession number: Q28893 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |