IGFBP4

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of cell growth Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 4 Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4
Gene namesⁱ	Name:IGFBP4
Organismⁱ	Ovis aries (Sheep)
Taxonomic identifierⁱ	9940 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis
Proteomesⁱ	UP000002356 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000152774	1 – 237	Insulin-like growth factor-binding protein 4Add BLAST		237

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	6 ↔ 32	PROSITE-ProRule annotation
Disulfide bondⁱ	9 ↔ 34	PROSITE-ProRule annotation
Disulfide bondⁱ	17 ↔ 38	PROSITE-ProRule annotation
Disulfide bondⁱ	23 ↔ 35	PROSITE-ProRule annotation
Disulfide bondⁱ	46 ↔ 59	PROSITE-ProRule annotation
Disulfide bondⁱ	53 ↔ 79	PROSITE-ProRule annotation
Glycosylationⁱ	104	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	110 ↔ 117	PROSITE-ProRule annotation
Disulfide bondⁱ	153 ↔ 183	PROSITE-ProRule annotation
Disulfide bondⁱ	194 ↔ 205	PROSITE-ProRule annotation
Disulfide bondⁱ	207 ↔ 228	PROSITE-ProRule annotation
Modified residueⁱ	234	PhosphoserineBy similarity	1

Post-translational modificationⁱ

There are two different molecular mass variants (29 kDa and 24 kDa forms). The 29 kDa form was shown to be N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

PTM databases

iPTMnetⁱ	Q28893

iPTMnetⁱ

Q28893

Expressionⁱ

Tissue specificityⁱ

Detected in adult ewe, liver > kidney > lung >> heart and also in several fetal tissues.1 Publication

Interactionⁱ

Subunit structureⁱ

Binds IGF2 more than IGF1.By similarity

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q28893
SMRⁱ	Q28893
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 82	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	150 – 228	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		79

Phylogenomic databases

HOVERGENⁱ	HBG002631

HOVERGENⁱ

HBG002631

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022327 IGFBP-4 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF7 PTHR11551:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01980 IGFBPFAMILY4
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q28893-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GKGMPCGVYT 
        60         70         80         90        100
PDCGSGLRCH PPRGVEKPLH TLVHGQGVCM ELAEIEAIQE SLQPSDKDEG 
       110        120        130        140        150
DHPNNSFSPC SAHDRKCLQK HLAKIRDRST SGGKMKVIGA PREEVRPVPQ 
       160        170        180        190        200
GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG 
       210        220        230 
QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE

Length:237

Mass (Da):25,869

Last modified:November 1, 1997 - v1

Checksum:ⁱEBC80D4C7667A226

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S77394 mRNA Translation: AAB33382.1
PIRⁱ	I47031
UniGeneⁱ	Oar.518

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q28893	Insulin-like growth factor-binding protein 4		CHICK		260	UniRef50_Q28893
Insulin-like growth factor-binding protein 4		CHEMY		259
Insulin-like growth factor-binding protein 4		ALLMI		242
insulin-like growth factor-binding protein 4		ALLSI		256
Uncharacterized protein		Cebus capucinus imitator		258
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S77394 mRNA Translation: AAB33382.1
PIRⁱ	I47031
UniGeneⁱ	Oar.518

3D structure databases

ProteinModelPortalⁱ	Q28893
SMRⁱ	Q28893
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

PTM databases

iPTMnetⁱ	Q28893

iPTMnetⁱ

Q28893

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG002631

HOVERGENⁱ

HBG002631

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022327 IGFBP-4 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF7 PTHR11551:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01980 IGFBPFAMILY4
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP4_SHEEP
Accessionⁱ	Q28893Primary (citable) accession number: Q28893
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	December 20, 2017
	This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q28893 (IBP4_SHEEP)

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Insulin-like growth factor-binding protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ