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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).By similarity

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha2-adrenergic receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
Gene namesi
Name:ADRA2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 149CytoplasmicBy similarityAdd BLAST20
Transmembranei150 – 173Helical; Name=4By similarityAdd BLAST24
Topological domaini174 – 192ExtracellularBy similarityAdd BLAST19
Transmembranei193 – 217Helical; Name=5By similarityAdd BLAST25
Topological domaini218 – 376CytoplasmicBy similarityAdd BLAST159
Transmembranei377 – 401Helical; Name=6By similarityAdd BLAST25
Topological domaini402 – 411ExtracellularBy similarity10
Transmembranei412 – 432Helical; Name=7By similarityAdd BLAST21
Topological domaini433 – 452CytoplasmicBy similarityAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690781 – 452Alpha-2A adrenergic receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei332PhosphoserineBy similarity1
Modified residuei354Omega-N-methylarginineBy similarity1
Lipidationi444S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ28838

Expressioni

Tissue specificityi

Retina, brain and olfactory lobe.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

Chemistry databases

BindingDBiQ28838

Structurei

3D structure databases

ProteinModelPortaliQ28838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ28838
KOiK04138

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SFEKKRGRSG QPSAEPRCEI NDQKWYVISS
210 220 230 240 250
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDATA AELPGSAERR
260 270 280 290 300
PNGLGPERGG VGPVGAEVES LQVQLNGAPG EPAPAGAGAD ALDLEESSSS
310 320 330 340 350
EHAERPPGSR RSERGPRAKG KARASQVKPG DSLPRRGPGA TGLGAPTAGP
360 370 380 390 400
AEERSGGGAK ASRWRGRQNR EKRFTFVLAV VIGVFVVCWF PFFFTYTLTA
410 420 430 440 450
IGCPVPPTLF KFFFWFGYCN SSLNPVIYTI FNHDFRRAFK KILCRGDRKR

IV
Length:452
Mass (Da):49,252
Last modified:May 1, 1999 - v2
Checksum:iF10C1DD2860CD6F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79030 Genomic DNA Translation: AAC24958.1
S66295 mRNA Translation: AAB28450.1
PIRiI46958
RefSeqiNP_776924.1, NM_174499.1
UniGeneiBt.88699

Genome annotation databases

GeneIDi282135
KEGGibta:282135

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79030 Genomic DNA Translation: AAC24958.1
S66295 mRNA Translation: AAB28450.1
PIRiI46958
RefSeqiNP_776924.1, NM_174499.1
UniGeneiBt.88699

3D structure databases

ProteinModelPortaliQ28838
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ28838
ChEMBLiCHEMBL4744

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ28838

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282135
KEGGibta:282135

Organism-specific databases

CTDi150

Phylogenomic databases

HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ28838
KOiK04138

Miscellaneous databases

PROiPR:Q28838

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_BOVIN
AccessioniPrimary (citable) accession number: Q28838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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