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Entry version 135 (08 May 2019)
Sequence version 2 (01 May 1999)
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Protein

von Willebrand factor

Gene

VWF

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.954

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VWF
Synonyms:F8VWF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000022686‹1 – 437By similarityAdd BLAST›437
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000022687438 – 2482von Willebrand factorAdd BLAST2045

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 2480By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi441 ↔ 482By similarity
Disulfide bondi450 ↔ 478By similarity
Disulfide bondi484 ↔ 495By similarity
Disulfide bondi541 ↔ 670By similarity
Disulfide bondi563 ↔ 705By similarity
Disulfide bondi572 ↔ 667By similarity
Disulfide bondi588 ↔ 595By similarity
Disulfide bondi734 ↔ 758By similarity
Disulfide bondi745 ↔ 785By similarity
Disulfide bondi763 ↔ 765By similarity
Disulfide bondi800 ↔ 804By similarity
Disulfide bondi823 ↔ 843By similarity
Disulfide bondi827 ↔ 839By similarity
Disulfide bondi870 ↔ 873By similarity
Glycosylationi905N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi908 ↔ 911By similarity
Disulfide bondi942 ↔ 1128By similarity
Glycosylationi1184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1338 ↔ 1339By similarity
Disulfide bondi1355 ↔ 1541By similarity
Disulfide bondi1548 ↔ 1573By similarity
Disulfide bondi1568 ↔ 1609Or C-1568 with C-1611PROSITE-ProRule annotation
Disulfide bondi1596 ↔ 1757By similarity
Disulfide bondi1619 ↔ 1754By similarity
Glycosylationi1640N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1641 ↔ 1792By similarity
Disulfide bondi1662 ↔ 1670By similarity
Glycosylationi1892N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1959N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2026N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2069N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2393 ↔ 2443By similarity
Disulfide bondi2408 ↔ 2457By similarity
Disulfide bondi2419 ↔ 2473By similarity
Disulfide bondi2423 ↔ 2475By similarity
Glycosylationi2459N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds.By similarity
N- and O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28833

PeptideAtlas

More...
PeptideAtlasi
Q28833

PRoteomics IDEntifications database

More...
PRIDEi
Q28833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000000759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28833

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 272VWFD 1PROSITE-ProRule annotationAdd BLAST212
Domaini326 – 381TIL 1Add BLAST56
Domaini450 – 501TIL 2Add BLAST52
Domaini540 – 748VWFD 2PROSITE-ProRule annotationAdd BLAST209
Domaini820 – 870TIL 3Add BLAST51
Domaini947 – 1127VWFA 1PROSITE-ProRule annotationAdd BLAST181
Domaini1167 – 1334VWFA 2PROSITE-ProRule annotationAdd BLAST168
Domaini1360 – 1540VWFA 3PROSITE-ProRule annotationAdd BLAST181
Domaini1618 – 1822VWFD 3PROSITE-ProRule annotationAdd BLAST205
Domaini1924 – 1997VWFC 1PROSITE-ProRule annotationAdd BLAST74
Domaini2098 – 2164VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini2249 – 2314VWFC 3PROSITE-ProRule annotationAdd BLAST66
Domaini2393 – 2481CTCKPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni438 – 461Amino-terminalAdd BLAST24
Regioni462 – 507E1Add BLAST46
Regioni500 – 527CXAdd BLAST28
Regioni1885 – 1930E2Add BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2176 – 2178Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The propeptide is required for multimerization of vWF and for its targeting to storage granules.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28833

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF361 PTHR11339:SF361, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 5 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DGCSCPEGQL LDDGRCVESA ECSCVHSGKR YPPGASLSRD CNTCICRNSL
60 70 80 90 100
WVCSNEDCPG ECLVTGQSHF KSFDNRHFTF SGVCQYLLAR DCQDHTFSVI
110 120 130 140 150
IETVQCADDP DAVCTRSVTV RLPSPHNSLV KLKHGGGVAM DGWDVQIPFL
160 170 180 190 200
QGDLRIQHTV MASVHLSYGE DLQIDWDGRG RLLVKLSPVY AGRTCGLCGN
210 220 230 240 250
YNGNQGDDFL TPAGLVEPLV EHFGNAWKLH GDCEDLRKQP TDPCSFNPRL
260 270 280 290 300
TRFAEEACAI LTSPKFQACH DAVGPLPYLQ NCHYDVCSCS DGRDCLCDAV
310 320 330 340 350
ATYAAACARR GVHIGWREPG FCALSCPPGQ VYLQCGTPCN LTCRSLSYPD
360 370 380 390 400
EECAEDCLEG CFCPPGLYLD GSGDCVPKAQ CPCYHDGEIF QPEDIFSDHH
410 420 430 440 450
TMCYCEDGFM HCSRAGAPGS LQPEVVLSSP LSHRSKRSLS CRPPMVKLVC
460 470 480 490 500
PADNPRAEGL ECAKTCQNYD LECVSTGCVS GCLCPPGMVR HENRCVALQR
510 520 530 540 550
CPCFHQGREY APGETVKVDC NTCVCRDRKW SCTDHVCDAS CSALGLAHYL
560 570 580 590 600
TFDGLKYLFP GECQYVLVQD YCGSNPGTFR ILLGNEGCGY PSLKCRKRVT
610 620 630 640 650
ILVDGGEIEL FDGEVMVKKP LKDETHFEVV ESGRFITVLL GSGLSVVWDR
660 670 680 690 700
HLGISVFLKQ TYQEQVCGLC GNFDGVQNND LTGSSLQVEE DPVDFGNSWK
710 720 730 740 750
VSPQCADTRK VPLDTSPATC HNNVMKQTMV DSSCRILTSD IFQDCNKLVD
760 770 780 790 800
PEPYLDVCIY DTCSCESIGD CACFCDTIAA YARVCAQHGK VVTWRTATLC
810 820 830 840 850
PQNCEERNLR EDGYQCEWRY NSCAPACPVT CQHPEPLACP VSCVEGCHAH
860 870 880 890 900
CPPGKILDEL LQTCVSPEDC PVCEAAGRRL APGKKIILNP RDPAHCQICH
910 920 930 940 950
CDGVNLTCEA CAEPVPPTEG PVSPTTPYEE DTPEPPLHDF FCSKLLDLVF
960 970 980 990 1000
LLDGSDKLSE ADFEALKVFV VGMMEHLHIS QKHIRVAVVE YHDGPHAYIS
1010 1020 1030 1040 1050
LQDRKRPSEL RRIASQVKYA GSEVASISEV LKYTLFQIFG RVDRPEASRI
1060 1070 1080 1090 1100
ALLLMASQEP RRLAQNLARY LQGLKKKKVT VIPVGIGPHV SLKQIRLIEK
1110 1120 1130 1140 1150
QAPENKAFVV SGVDELEQRK NEIISYLCDL APEVPAPTRR PLVAQVTVAP
1160 1170 1180 1190 1200
ELPGVSTLEP KKRMALDVVF VLEGSDKVGE ANFNRSTEFV EEVIRRMDVG
1210 1220 1230 1240 1250
RDSVHVTVLQ YSYVVAVEHS FREAQSKGEV LQRVREIRFQ GGNRTNTGLA
1260 1270 1280 1290 1300
LQYLSEHSFS ASQGDREEAP NLVYMVTGNP ASDEIKRMPG DIQVVPIGVG
1310 1320 1330 1340 1350
PDVDMQELER LSWPNAPIFI QDFETLPREA PDLVLQRCCS GEGPHLPTQA
1360 1370 1380 1390 1400
PVPDCSQPLG VVLLLDGSSS LPASYFDEMK SFTKAFISKA NIGPQLTQVS
1410 1420 1430 1440 1450
VLQYGSITTI DLPWNMPLEK AHLRGLVDLM QREGGPSQIG DALGFAVRYV
1460 1470 1480 1490 1500
MSQVHGARPE ASKAVVIVVT DTSTDSVDAA AAAARSNRVA VFPIGIGDRY
1510 1520 1530 1540 1550
DEAQLRTLAG PGASSNVVKL QRIEDLPTLV TLGNSFLHKL CSGFVRVCID
1560 1570 1580 1590 1600
EDGSERKPGD VWTLPDQCHT VTCLPDGQTL LKSHRVNCDQ GLQPSCPSNQ
1610 1620 1630 1640 1650
PPIRVEEACG CRWTCPCVCT GSSTRHIVTF DGQNFKLMGN CSYVLFHNKE
1660 1670 1680 1690 1700
QDLEVILHNG ACGAGARQAC MKSIEVKHNG LSVELHRDME VVVNGRQVSV
1710 1720 1730 1740 1750
PYVGGNMEVG IYGTIMYEVR FNHLGHILTF TPQNNEFQLQ LSPKTFASKM
1760 1770 1780 1790 1800
YGLCGICDEN GANDFMLRDG TVTTDWKTMV QEWAVQQPGQ MCQPVPKEQC
1810 1820 1830 1840 1850
PVSGGYQCQV LLSALFAECH KVLAPAAYFA ICQQDSCHQE QVCEAVASYA
1860 1870 1880 1890 1900
HLCRTKGVCV DWRTPDFCAV SCPPSLVYNH CEHGCPRHCE GNSSSCGDHP
1910 1920 1930 1940 1950
SEGCFCPPHQ VMLGSSCVPE EACTQCVDDD GIRHQFLETW VPDHQPCQIC
1960 1970 1980 1990 2000
TCLSGRRVNC TLQPCPTARA PACGLCEVAR LRQEAHQCCP EYECVCDLVS
2010 2020 2030 2040 2050
CDLPPVPHCE GGLQPTLTNP GECRPNFTCA CRKEECPRGP LPSCPPHRTP
2060 2070 2080 2090 2100
ALRKTQCCDE YECACNCVNT TLSCPLGYLA STVTNDCGCT TTTCLPDKVC
2110 2120 2130 2140 2150
VHRGTVYPVG QFWEEGCDVC TCTDLEDAVM GLRVAQCAQK PCEDSCRPGF
2160 2170 2180 2190 2200
TYVLHEGECC GKCLPSACKV VIGSFRGDSV SYWKSVGSHW ASPENPCLIN
2210 2220 2230 2240 2250
ECVRVKEEVF VQQRNVSCPM LDVPTCPVGF QLSCKTSGCC PTCRCEPVEA
2260 2270 2280 2290 2300
CLLNGTIIGA GESLMIDVCT TCRCMLQEGV VFGFKLECKK TTCEACPLGY
2310 2320 2330 2340 2350
KEEKMPGECC GRCLPTACTI QLRGGQIMTL KRDETLQDGC DSHFCRVNER
2360 2370 2380 2390 2400
GEYIWEKRIT GCPPFDQHKC LAAGGKIMKI PGTCCDTCEE PECKDMTARL
2410 2420 2430 2440 2450
QYVKVGNCRS EEEVDIHYCQ GKCTSKAVYS IDTEDVEDQC ACCSPTRTEP
2460 2470 2480
MQVPLRCTNG STIYHEVLNA IQCKCSPRKC SK
Length:2,482
Mass (Da):272,397
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD499B7DDFBBCAEDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF052036 mRNA Translation: AAC06229.1
S64541 mRNA Translation: AAB27829.2

Protein sequence database of the Protein Information Resource

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PIRi
PN0563

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052036 mRNA Translation: AAC06229.1
S64541 mRNA Translation: AAB27829.2
PIRiPN0563

3D structure databases

SMRiQ28833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000759

Protein family/group databases

MEROPSiI08.954

Proteomic databases

PaxDbiQ28833
PeptideAtlasiQ28833
PRIDEiQ28833

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
InParanoidiQ28833

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 3 hits
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 3 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 3 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 5 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVWF_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28833
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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