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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi60 – 128HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome Y

Organism-specific databases

VGNCiVGNC:5889 SRY

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486951 – 204Sex-determining region Y proteinAdd BLAST204

Proteomic databases

PaxDbiQ28798

Expressioni

Gene expression databases

BgeeiENSPTRG00000022469 Expressed in 3 organ(s), highest expression level in heart

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000038745

Structurei

3D structure databases

ProteinModelPortaliQ28798
SMRiQ28798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRY family.Curated

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000008601
HOVERGENiHBG008712
InParanoidiQ28798
KOiK09266
OMAiDCTKATH
OrthoDBiEOG091G0JDD

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017253 SRY
PANTHERiPTHR10270:SF199 PTHR10270:SF199, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF037653 SRY, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q28798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSYASAMLS VFNSDDYSPA VQQNIPALRR SSSFLCTESY NSKYQRETGE
60 70 80 90 100
NSKDSVQDRV KRPMNAFFVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKANMLPK NCSLLPADPA
160 170 180 190 200
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH

WTKL
Length:204
Mass (Da):24,047
Last modified:November 1, 1996 - v1
Checksum:i1892AB538905329D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86380 Genomic DNA Translation: CAA60140.1
AY679780 mRNA Translation: AAT84368.1
DQ977342 Genomic DNA Translation: ABM91955.1
AJ222687 Genomic DNA Translation: CAA10942.1
PIRiS35558
RefSeqiNP_001008988.1, NM_001008988.1
UniGeneiPtr.6524

Genome annotation databases

EnsembliENSPTRT00000041956; ENSPTRP00000038745; ENSPTRG00000022469
GeneIDi449510
KEGGiptr:449510

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The tenuous nature of sex - Issue 80 of March 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86380 Genomic DNA Translation: CAA60140.1
AY679780 mRNA Translation: AAT84368.1
DQ977342 Genomic DNA Translation: ABM91955.1
AJ222687 Genomic DNA Translation: CAA10942.1
PIRiS35558
RefSeqiNP_001008988.1, NM_001008988.1
UniGeneiPtr.6524

3D structure databases

ProteinModelPortaliQ28798
SMRiQ28798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000038745

Proteomic databases

PaxDbiQ28798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000041956; ENSPTRP00000038745; ENSPTRG00000022469
GeneIDi449510
KEGGiptr:449510

Organism-specific databases

CTDi6736
VGNCiVGNC:5889 SRY

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000008601
HOVERGENiHBG008712
InParanoidiQ28798
KOiK09266
OMAiDCTKATH
OrthoDBiEOG091G0JDD

Gene expression databases

BgeeiENSPTRG00000022469 Expressed in 3 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017253 SRY
PANTHERiPTHR10270:SF199 PTHR10270:SF199, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF037653 SRY, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRY_PANTR
AccessioniPrimary (citable) accession number: Q28798
Secondary accession number(s): A2T700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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