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UniProtKB - Q28756 (OXYR_SHEEP)
Protein
Oxytocin receptor
Gene
OXTR
Organism
Ovis aries (Sheep)
Status
Functioni
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- oxytocin receptor activity Source: InterPro
- vasopressin receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Oxytocin receptorShort name: OT-R |
Gene namesi | Name:OXTR |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 64 – 74 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 75 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 98 – 113 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 114 – 135 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 136 – 154 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 202 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 203 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 226 – 277 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 278 – 296 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 297 – 311 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 312 – 334 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 335 – 391 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070003 | 1 – 391 | Oxytocin receptorAdd BLAST | 391 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 112 ↔ 187 | PROSITE-ProRule annotation | ||
Modified residuei | 370 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q28756-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGAFAANWS AEAVNGSAAP PGTEGNRTAG PPQRNEALAR VEVAVLSLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLAVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTEAAAA EASAGAEGAA
260 270 280 290 300
ADCAGRAALA RVSNVKLISK AKIRTVKMTF IVVLAFIVCW TPFFFKQMWS
310 320 330 340 350
VWDADAPKEA SAFIIAMLLA SLNSCCNPWI YMLFTGHLFQ DLVQRFLCCS
360 370 380 390
FRRLKGSQLG ETSVTKKIHS YTFVLSRHSS SQRSCSQPST V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87986 mRNA Translation: CAA61239.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87986 mRNA Translation: CAA61239.1 |
3D structure databases
SMRi | Q28756 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000008033 |
Protein family/group databases
GPCRDBi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OXYR_SHEEP | |
Accessioni | Q28756Primary (citable) accession number: Q28756 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families