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Entry version 108 (07 Apr 2021)
Sequence version 2 (10 Feb 2021)
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Protein

Fibronectin

Gene

FN1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei613Important for superfibronectin formationBy similarity1
Sitei616Important for superfibronectin formationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi857 – 1122By similarityAdd BLAST266

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Heparin-binding
Biological processAcute phase, Cell adhesion, Cell shape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FibronectinBy similarity
Short name:
FN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FN1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000158531‹1 – 2427FibronectinAdd BLAST›2427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2 ↔ 28PROSITE-ProRule annotation
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi47 ↔ 75PROSITE-ProRule annotation
Disulfide bondi73 ↔ 85PROSITE-ProRule annotation
Disulfide bondi91 ↔ 119PROSITE-ProRule annotation
Disulfide bondi117 ↔ 129PROSITE-ProRule annotation
Disulfide bondi136 ↔ 165PROSITE-ProRule annotation
Disulfide bondi163 ↔ 175PROSITE-ProRule annotation
Disulfide bondi181 ↔ 210PROSITE-ProRule annotation
Disulfide bondi208 ↔ 220PROSITE-ProRule annotation
Disulfide bondi258 ↔ 285PROSITE-ProRule annotation
Disulfide bondi283 ↔ 292PROSITE-ProRule annotation
Disulfide bondi310 ↔ 336PROSITE-ProRule annotation
Disulfide bondi324 ↔ 351PROSITE-ProRule annotation
Disulfide bondi370 ↔ 396PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi380N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi384 ↔ 411PROSITE-ProRule annotation
Disulfide bondi420 ↔ 448PROSITE-ProRule annotation
Disulfide bondi446 ↔ 458PROSITE-ProRule annotation
Disulfide bondi468 ↔ 495PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi492N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi493 ↔ 505PROSITE-ProRule annotation
Disulfide bondi511 ↔ 539PROSITE-ProRule annotation
Disulfide bondi537 ↔ 549PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei826SulfotyrosineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Modified residuei831SulfotyrosineSequence analysis1
Glycosylationi957N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1194N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1241N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1854N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2149N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2247 ↔ 2276PROSITE-ProRule annotation
Disulfide bondi2274 ↔ 2286PROSITE-ProRule annotation
Disulfide bondi2292 ↔ 2319PROSITE-ProRule annotation
Disulfide bondi2317 ↔ 2329PROSITE-ProRule annotation
Disulfide bondi2336 ↔ 2362PROSITE-ProRule annotation
Disulfide bondi2360 ↔ 2371PROSITE-ProRule annotation
Modified residuei2404PhosphothreonineBy similarity1
Modified residuei2425PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated.By similarity
Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).By similarity
Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.By similarity
Serotonylated on Gln residues by TGM2 in response to hypoxia.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Sulfation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000010104, Expressed in upper lobe of left lung and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers.

Interacts with FBLN1, FBLN7, AMBP, TNR, LGALS3BP, COL13A1 and COMP.

Interacts with FST3 and MYOC (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000008718

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28749

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 40Fibronectin type-I 1PROSITE-ProRule annotationAdd BLAST›40
Domaini45 – 88Fibronectin type-I 2PROSITE-ProRule annotationAdd BLAST44
Domaini89 – 132Fibronectin type-I 3PROSITE-ProRule annotationAdd BLAST44
Domaini134 – 178Fibronectin type-I 4PROSITE-ProRule annotationAdd BLAST45
Domaini179 – 223Fibronectin type-I 5PROSITE-ProRule annotationAdd BLAST45
Domaini256 – 295Fibronectin type-I 6PROSITE-ProRule annotationAdd BLAST40
Domaini305 – 353Fibronectin type-II 1PROSITE-ProRule annotationAdd BLAST49
Domaini365 – 413Fibronectin type-II 2PROSITE-ProRule annotationAdd BLAST49
Domaini418 – 461Fibronectin type-I 7PROSITE-ProRule annotationAdd BLAST44
Domaini466 – 508Fibronectin type-I 8PROSITE-ProRule annotationAdd BLAST43
Domaini509 – 552Fibronectin type-I 9PROSITE-ProRule annotationAdd BLAST44
Domaini560 – 653Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini667 – 762Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini763 – 852Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini859 – 948Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini949 – 1038Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini1039 – 1125Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST87
Domaini1126 – 1220Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST95
Domaini1221 – 1309Fibronectin type-III 8; extra domain BPROSITE-ProRule annotationAdd BLAST89
Domaini1310 – 1402Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST93
Domaini1403 – 1490Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST88
Domaini1491 – 1584Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST94
Domaini1585 – 1676Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST92
Domaini1677 – 1764Fibronectin type-III 13; extra domain APROSITE-ProRule annotationAdd BLAST88
Domaini1765 – 1858Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST94
Domaini1859 – 1945Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST87
Domaini1946 – 2036Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST91
Domaini2144 – 2238Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST95
Domaini2245 – 2289Fibronectin type-I 10PROSITE-ProRule annotationAdd BLAST45
Domaini2290 – 2332Fibronectin type-I 11PROSITE-ProRule annotationAdd BLAST43
Domaini2334 – 2374Fibronectin type-I 12PROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 222Fibrin- and heparin-binding 1By similarityAdd BLAST221
Regioni258 – 558Collagen-bindingBy similarityAdd BLAST301
Regioni414 – 427Critical for collagen bindingBy similarityAdd BLAST14
Regioni1308 – 1581Cell-attachmentBy similarityAdd BLAST274
Regioni1762 – 2032Heparin-binding 2By similarityAdd BLAST271
Regioni1854 – 2032Binds to FBLN1By similarityAdd BLAST179
Regioni2033 – 2152V region (type III connecting segment, IIICS)By similarityAdd BLAST120
Regioni2247 – 2378Fibrin-binding 2By similarityAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1565 – 1567Cell attachment siteBy similarity3

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPTS, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000916_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWLAPQS

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 17 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 2 hits
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039, fn1, 11 hits
PF00040, fn2, 2 hits
PF00041, fn3, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 11 hits
SSF57440, SSF57440, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01253, FN1_1, 12 hits
PS51091, FN1_2, 12 hits
PS00023, FN2_1, 2 hits
PS51092, FN2_2, 2 hits
PS50853, FN3, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. The diversity of isoforms depends on the V region and either of the two extra domains which can be either included or excluded (partially or completely for the V region).Curated
Isoform 1 (identifier: Q28749-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
GCYDNGKHYQ INQQWERTYL GNALVCTCYG GSRGFNCESK PEPEETCFDK
60 70 80 90 100
YTGNTYRVGD TYERPKDSMI WDCTCIGAGR GRISCTIANR CHEGGQSYKI
110 120 130 140 150
GDTWRRPHET GGYMLECVCL GNGKGEWTCK PIAEKCFDHA AGTSYVVGET
160 170 180 190 200
WEKPYQGWMM VDCTCLGEGS GRITCTSRNR CNDQDTRTSY RIGDTWSKKD
210 220 230 240 250
NRGNLLQCIC TGNGRGEWKC ERHASLQTTS TGSGPFSDVR AAVYQPQPHP
260 270 280 290 300
QPAPYGHCVT DSGVVYSEGM QWLKTQGNKQ MLCTCLGNGV SCQETAVTQT
310 320 330 340 350
YGGNSNGEPC VLPFTYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF
360 370 380 390 400
CTDHTVLVQT RGGNSNGALC HFPFLYNNHN YTDCTSEGRR DNMKWCGTTQ
410 420 430 440 450
NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDM GHMMRCTCVG
460 470 480 490 500
NGRGEWTCVA YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR
510 520 530 540 550
GRWKCDPVDQ CQDSETRTFY QIGDSWEKYV HGVRYQCYCY GRGIGEWHCQ
560 570 580 590 600
PLQTYPGTSG PVQVIITETP SQPNSHPIQW NAPEPSHISK YILRWRPKNS
610 620 630 640 650
VGRWKEATIP GHLNSYTIKG LRPGVMYEGQ LISIQQYGHR EVTRFDFTTT
660 670 680 690 700
STSTPVTSNT VTGETTPLSP VVATSESVTE ITASSFVVSW VSASDTVSGF
710 720 730 740 750
LVEYELSEEG DEPKYLDLPS TVTSVNIPDL LPGRKYIVNV YQISEEGKQS
760 770 780 790 800
LILSTSQTTA PDAPPDPTVD QVDDTSIVVR WSRPQAPITG YRVVYSPSVE
810 820 830 840 850
GSSTELNLPE TANSVTLSDL QPGVQYNITI YAVEENQESA PVFIQQETTG
860 870 880 890 900
VPRSDEVPPP KDLQFVEVTD VKVTIMWTPP DSAVTGYRVD VLPVHLPGEN
910 920 930 940 950
GQRLPVSRNT FAEITGLSPG VTYYFKVFAV NHGRESRPLT AQQATKLDAP
960 970 980 990 1000
TNLQFVNETD SSVLVIWTPP RARITGYQLT IGPTRGGQPK QHNVGPTVSK
1010 1020 1030 1040 1050
YLLRNLQPGS EYTVTLIAVK GNNQSPKVTG VFTTLQPQSS IPPYSTEVTE
1060 1070 1080 1090 1100
TSIVITWTPA PRIGFKLGVR PSQGGEAPRE VTSESGSIVV SGLTPGVEYV
1110 1120 1130 1140 1150
YSIQVLRDGK ERDAPIVNTV VTPLSPPTNL HLEANPDTGV LTVSWEKSTT
1160 1170 1180 1190 1200
PDITGYRITT TPTNGQQGYS LEEVVHADQN SCIFENLSPG LEYNVSVYTV
1210 1220 1230 1240 1250
KDDKESVPVS DTIIPEVPQL TDLSFVDITD SSIGLRWTPL NSSTIIGYRI
1260 1270 1280 1290 1300
TVVAAGEGIP IFEDFVDSSV GYYTVTGLEP GIDYDISVIT LINGGESAPT
1310 1320 1330 1340 1350
TLTQQTAVPS PTDLRFTNIG PDTMRVTWAP PPSIELTNFL VRYSPVKNEE
1360 1370 1380 1390 1400
DVAELSISPS DNAVVLTNLL PGTEYLVSVS SVYEQHESTP VRGRQKTGLD
1410 1420 1430 1440 1450
APTGIDFSDV TPNSFTVYWT PPRAPITGFW IRHHPEHGVG RPREDRVPPS
1460 1470 1480 1490 1500
RNSITLTNLN PGTEYVVSIV ALNGREQSPP LIGQQSTVSD VPRDLEVIAS
1510 1520 1530 1540 1550
TPTSLLISWE APAVTVRYYR ITYGETGGNS PVQEFTVPGS KSTATISGLK
1560 1570 1580 1590 1600
PGADYTITVY AVTGRGDSPA SSKPISIDYH TEIDKPSQMQ VTDVQDNSIS
1610 1620 1630 1640 1650
VRWLPSSSPV TGYRVTTTPK NGAGPTKTKT AGPDQTEMTI EGLQPTVEYV
1660 1670 1680 1690 1700
VSVYAQNRNG ESQPLVQTAV TNIDRPKGLA FTDVDVDSIK IAWESPQGQV
1710 1720 1730 1740 1750
SRYRVTYSSP EDGIHELFPA PDGEEDTAEL QGLRPGSEYT VSVVALHDDM
1760 1770 1780 1790 1800
ESQPLIGTQS TAIPAPTNLK FTQVTPTSLS AQWTPPNVQL TGYRVRVTPK
1810 1820 1830 1840 1850
EKTGPMKEIN LAPDSSSVVV SGLMVATKYE VSVYALKDTL TSRPVQGVIT
1860 1870 1880 1890 1900
TLENVSPPRR ARVTDATETT ITISWRTKTE TITGFRVDAI PANGQNPIQR
1910 1920 1930 1940 1950
IIKPDVRSYT ITGLQPGTDY KIHLYTLNDN AQSSPVIIDA STAIDAPSNL
1960 1970 1980 1990 2000
HFLATTPNSL LVSWQPPRAK ITGYIIKFEK PGSPPREVVP RPRPGVTEAT
2010 2020 2030 2040 2050
ITGLEPGTEY TIYIIALKNN QKSDPLIGRK KTDELPQLVT LPHPNLHGPE
2060 2070 2080 2090 2100
ILDVPSTVQK TPFITNPGYD TGNGIQLPGT SGQQPSVGQQ MIFEEHGFRR
2110 2120 2130 2140 2150
TTPPTTATPV KLRPRPYLPN VDEDIQIGHV PRGDVDYHLY PHVLGLNPNA
2160 2170 2180 2190 2200
STGQEALSQT TISWTPFQES SEYIISCHPV GTDEQPLQFR VPGTSTSATL
2210 2220 2230 2240 2250
TGLTRGATYN IIVEALKDQR RHKVREEVVT VGNSVNEGLN QPTDDSCFDP
2260 2270 2280 2290 2300
YTVTHYAVGE EWERLSESGF KLSCQCLGFG SGHFKCDSSK WCHDNGVNYK
2310 2320 2330 2340 2350
IGEKWDRQGE NGQMMSCTCL GNGKGEFKCD PHEATCYDDG KTYHVGEQWQ
2360 2370 2380 2390 2400
KEYLGAICSC TCFGGQRGWR CDNCRRPGVE PSPDSSTGHS YNQYTQRYHQ
2410 2420
RTNTNVNCPI ECFMPLDVQA DREDSRE
Length:2,427
Mass (Da):267,281
Last modified:February 10, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i153E0231A30FEDDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02042615 Genomic DNA No translation available.
S80206 mRNA Translation: AAB35493.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02042615 Genomic DNA No translation available.
S80206 mRNA Translation: AAB35493.1

3D structure databases

SMRiQ28749
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008718

Phylogenomic databases

eggNOGiENOG502QPTS, Eukaryota
HOGENOMiCLU_000916_0_0_1
OMAiHWLAPQS
TreeFamiTF329915

Gene expression databases

BgeeiENSOCUG00000010104, Expressed in upper lobe of left lung and 14 other tissues

Family and domain databases

CDDicd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 17 hits
Gene3Di2.10.10.10, 2 hits
2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like
PfamiView protein in Pfam
PF00039, fn1, 11 hits
PF00040, fn2, 2 hits
PF00041, fn3, 17 hits
SMARTiView protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 17 hits
SUPFAMiSSF49265, SSF49265, 11 hits
SSF57440, SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01253, FN1_1, 12 hits
PS51091, FN1_2, 12 hits
PS00023, FN2_1, 2 hits
PS51092, FN2_2, 2 hits
PS50853, FN3, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFINC_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28749
Secondary accession number(s): G1U9R6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 10, 2021
Last modified: April 7, 2021
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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