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Protein

Cyclic nucleotide-gated olfactory channel

Gene

CNGA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei521cAMPSequence analysis1
Binding sitei536cAMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi462 – 584cAMPBy similarityAdd BLAST123

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Ion channel, Ligand-gated ion channel
Biological processIon transport, Olfaction, Sensory transduction, Transport
LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Aorta CNG channel
Short name:
RACNG
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:CNGA2
Synonyms:CNCG2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicSequence analysisAdd BLAST140
Transmembranei141 – 160Helical; Name=H1Sequence analysisAdd BLAST20
Topological domaini161 – 173ExtracellularSequence analysisAdd BLAST13
Transmembranei174 – 192Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini193 – 216CytoplasmicSequence analysisAdd BLAST24
Transmembranei217 – 236Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini237 – 274ExtracellularSequence analysisAdd BLAST38
Transmembranei275 – 297Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini298 – 349CytoplasmicSequence analysisAdd BLAST52
Transmembranei350 – 369Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini370 – 453ExtracellularSequence analysisAdd BLAST84
Transmembranei454 – 474Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini475 – 664CytoplasmicSequence analysisAdd BLAST190

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193141 – 664Cyclic nucleotide-gated olfactory channelAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008136

Structurei

3D structure databases

ProteinModelPortaliQ28718
SMRiQ28718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili597 – 640By similarityAdd BLAST44

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500 Eukaryota
ENOG410YWWI LUCA
HOGENOMiHOG000007898
HOVERGENiHBG000281
InParanoidiQ28718
KOiK04949

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032406 CLZ_dom
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF16526 CLZ, 1 hit
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q28718-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEKSNGVKS SPANNHNNHV PATIKANGKD ESRTRSRPQS AADDDTSSEL
60 70 80 90 100
QRLAEMDAPQ QRRGGFRRIV RLVGVIRQWA NRNFREEEAR PDSFLERFRG
110 120 130 140 150
PELQTVTTQQ GDGKGDKDGD GKGTKKKFEL FVLDPAGDWY YRWLFVIAMP
160 170 180 190 200
VLYNWCLLVA RACFSDLQRG YFLVWLVLDY FSDVVYIADL FIRLRTGFLE
210 220 230 240 250
QGLLVKDPKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVGI HNPELRFNRL
260 270 280 290 300
LHFARMFEFF DRTETRTSYP NIFRISNLVL YILVIIHWNA CIYYAISKSI
310 320 330 340 350
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY
360 370 380 390 400
LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK
410 420 430 440 450
VSKEMEAKVI KWFDYLWTNK KTVDEREVLK NLPAKLRAEI AINVHLSTLK
460 470 480 490 500
KVRIFQDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA
510 520 530 540 550
VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC
560 570 580 590 600
LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA ASMEVDVQEK
610 620 630 640 650
LKQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLEVKM KQNTEDDYLS
660
DGMNSPEPAA AEQP
Length:664
Mass (Da):76,206
Last modified:November 1, 1997 - v1
Checksum:i5E9170D0B322B3E9
GO

Sequence cautioni

The sequence CAA42201 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59668 mRNA Translation: CAA42201.1 Different initiation.
PIRiS35691
RefSeqiNP_001075863.1, NM_001082394.1
UniGeneiOcu.3283

Genome annotation databases

GeneIDi100009269
KEGGiocu:100009269

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59668 mRNA Translation: CAA42201.1 Different initiation.
PIRiS35691
RefSeqiNP_001075863.1, NM_001082394.1
UniGeneiOcu.3283

3D structure databases

ProteinModelPortaliQ28718
SMRiQ28718
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008136

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009269
KEGGiocu:100009269

Organism-specific databases

CTDi1260

Phylogenomic databases

eggNOGiKOG0500 Eukaryota
ENOG410YWWI LUCA
HOGENOMiHOG000007898
HOVERGENiHBG000281
InParanoidiQ28718
KOiK04949

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032406 CLZ_dom
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF16526 CLZ, 1 hit
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNGA2_RABIT
AccessioniPrimary (citable) accession number: Q28718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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