Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily E member 1

Gene

KCNE1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 1
Alternative name(s):
Delayed rectifier potassium channel subunit IsK
IKs producing slow voltage-gated potassium channel subunit beta Mink
Minimal potassium channel
Gene namesi
Name:KCNE1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 67HelicalSequence analysisAdd BLAST23
Topological domaini68 – 130CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075200

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442821 – 130Potassium voltage-gated channel subfamily E member 1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei103Phosphoserine; by PKCBy similarity1

Post-translational modificationi

Phosphorylation inhibits the potassium current.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011595

Chemistry databases

BindingDBiQ28705

Structurei

3D structure databases

SMRiQ28705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY71 Eukaryota
ENOG410Y1SF LUCA
HOGENOMiHOG000113207
HOVERGENiHBG052226
InParanoidiQ28705
KOiK04894

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01604 KCNE1CHANNEL
PR00168 KCNECHANNEL

Sequencei

Sequence statusi: Complete.

Q28705-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPPNATAVM PFLTTLGEET AHLQGSSATS LARRGPLGDD GQMEALYILM
60 70 80 90 100
VLGFFGFFTL GIMLSYIRSQ KLEHSHDPFN VYIEANDWQE KDRAYFQARV
110 120 130
LESCRGCYVL ENQLAVEHPD THLPELKPSL
Length:130
Mass (Da):14,617
Last modified:November 1, 1996 - v1
Checksum:iE7B10048F41E205E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41659 Genomic DNA Translation: AAA93505.1
RefSeqiNP_001103292.1, NM_001109822.1
UniGeneiOcu.7288

Genome annotation databases

GeneIDi100126000
KEGGiocu:100126000

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41659 Genomic DNA Translation: AAA93505.1
RefSeqiNP_001103292.1, NM_001109822.1
UniGeneiOcu.7288

3D structure databases

SMRiQ28705
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011595

Chemistry databases

BindingDBiQ28705
ChEMBLiCHEMBL1075200

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100126000
KEGGiocu:100126000

Organism-specific databases

CTDi3753

Phylogenomic databases

eggNOGiENOG410IY71 Eukaryota
ENOG410Y1SF LUCA
HOGENOMiHOG000113207
HOVERGENiHBG052226
InParanoidiQ28705
KOiK04894

Miscellaneous databases

PROiPR:Q28705

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01604 KCNE1CHANNEL
PR00168 KCNECHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE1_RABIT
AccessioniPrimary (citable) accession number: Q28705
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again