UniProtKB - Q28690 (EI2BB_RABIT)
Protein
Translation initiation factor eIF-2B subunit beta
Gene
EIF2B2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
GO - Molecular functioni
- ATP binding Source: UniProtKB
- GTP binding Source: UniProtKB
- translation initiation factor activity Source: UniProtKB-KW
GO - Biological processi
- central nervous system development Source: UniProtKB
- myelination Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Translation initiation factor eIF-2B subunit betaAlternative name(s): eIF-2B GDP-GTP exchange factor subunit beta |
Gene namesi | Name:EIF2B2 Synonyms:EIF2BB |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB
- eukaryotic translation initiation factor 2B complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156063 | 1 – 351 | Translation initiation factor eIF-2B subunit betaAdd BLAST | 351 |
Interactioni
Subunit structurei
Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
Protein-protein interaction databases
IntActi | Q28690, 2 interactors |
STRINGi | 9986.ENSOCUP00000008770 |
Family & Domainsi
Sequence similaritiesi
Belongs to the eIF-2B alpha/beta/delta subunits family.Curated
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
InParanoidi | Q28690 |
OrthoDBi | 918011at2759 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
i Sequence
Sequence statusi: Complete.
Q28690-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGATEKGSE LSERIESFVE ALKRGGGQRS SEDMARETLG LLRRIITDHR
60 70 80 90 100
WSNAGELMEL IRREGRRMMA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFSFHYAQLQ SNIVEAINEL LVELEGTTEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGL SRTVEAFLRE AARKRKFHVI VAECAPFCQG
210 220 230 240 250
HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGALRAVTG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILDKVGCHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPEDHV
L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48222 mRNA Translation: CAA88255.1 |
PIRi | S56172 |
RefSeqi | NP_001076100.1, NM_001082631.1 |
Genome annotation databases
GeneIDi | 100009318 |
KEGGi | ocu:100009318 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48222 mRNA Translation: CAA88255.1 |
PIRi | S56172 |
RefSeqi | NP_001076100.1, NM_001082631.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q28690, 2 interactors |
STRINGi | 9986.ENSOCUP00000008770 |
Genome annotation databases
GeneIDi | 100009318 |
KEGGi | ocu:100009318 |
Organism-specific databases
CTDi | 8892 |
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
InParanoidi | Q28690 |
OrthoDBi | 918011at2759 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EI2BB_RABIT | |
Accessioni | Q28690Primary (citable) accession number: Q28690 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families