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Protein

Alpha-1-syntrophin

Gene

SNTA1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: CACAO

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 acidic component 1
59-1 DAP
Syntrophin-1
Gene namesi
Name:SNTA1
Synonyms:SNT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840081 – 505Alpha-1-syntrophinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineBy similarity1
Modified residuei184PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Highly expressed in skeletal and cardiac muscle and is also detected in brain.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with the dystrophin related protein DTNA; SGCG of the dystrophin glycoprotein complex; NOS1; GRB2; GA; TGFA; MAPK12 and the sodium channel proteins SCN4A and SCN5A (By similarity). Interacts with the dystrophin protein DMD in a calmodulin dependent manner and with related protein UTRN; SGCA of the dystrophin glycoprotein complex; F-actin; calmodulin and with the other members of the syntrophin family SNTB1 and SNTB2. Interacts with MYOC; regulates muscle hypertrophy (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ28626
IntActiQ28626, 4 interactors
MINTiQ28626
STRINGi9986.ENSOCUP00000010241

Structurei

3D structure databases

ProteinModelPortaliQ28626
SMRiQ28626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 269PH 1PROSITE-ProRule annotationAdd BLAST264
Domaini87 – 170PDZPROSITE-ProRule annotationAdd BLAST84
Domaini293 – 401PH 2PROSITE-ProRule annotationAdd BLAST109
Domaini449 – 505SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni483 – 505Calmodulin-bindingBy similarityAdd BLAST23

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner (By similarity). It contains actin-binding sites.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRM Eukaryota
ENOG410XS4Y LUCA
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ28626

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR028552 SNTA1
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF6 PTHR10554:SF6, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q28626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGRRAPRT GLLELRAGTG AGAGGERWQR VLVSLAEDAL TVSPADGEPG
60 70 80 90 100
PEPGAVREPE PAQINGAAEP GAAPPQLPEA LLLQRRRVTV RKADAGGLGI
110 120 130 140 150
SIKGGRENKM PILISKIFKG LAADQTEALF VGDAILSVNG EDLSSATHDE
160 170 180 190 200
AVQALKKTGK EVVLEVKYMK EVSPYFKNSA GGTSVGWDSP PASPLQRQPS
210 220 230 240 250
SPGPQTRNLS EAKHVPLKMA YVSRRCTPSD PEHRYLEICS ADGQDTIFLR
260 270 280 290 300
AKDEASARSW AGAIQAQINA LLPWVKDELQ ALLAASSPAG SQDIKQIGWL
310 320 330 340 350
TEQLPSGGTA PTLALLTEKE LLLYGGLPQT REALSRPART APLIATRLVH
360 370 380 390 400
SGPSKGSVPY DAELSFALRT GTRHGVDTHL FSVESPQELA AWTRQLVDGC
410 420 430 440 450
HRAAEGVQEV STACTWNGRP CNLSVHIDKG FTLWAAEPGA ARAVLLRQPF
460 470 480 490 500
EKLQMSSDDG ASLLFLDFGG AEGEIQLDLH SCPKTMVFII HSFLSAKVTR

LGLLA
Length:505
Mass (Da):53,760
Last modified:November 1, 1996 - v1
Checksum:i5E4151266C0DD1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01243 mRNA Translation: AAA68937.1
PIRiA53214
RefSeqiNP_001075802.1, NM_001082333.1
UniGeneiOcu.6246

Genome annotation databases

GeneIDi100009179
KEGGiocu:100009179

Similar proteinsi

Entry informationi

Entry nameiSNTA1_RABIT
AccessioniPrimary (citable) accession number: Q28626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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