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Entry version 85 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Tubulointerstitial nephritis antigen

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

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MEROPSi
C01.973

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tubulointerstitial nephritis antigenImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 105SMBInterPro annotationAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1544 Eukaryota
ENOG410YN9K LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000241342

Database of Orthologous Groups

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OrthoDBi
1436535at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C
IPR001212 Somatomedin_B_dom
IPR033164 TINAG

The PANTHER Classification System

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PANTHERi
PTHR12411:SF274 PTHR12411:SF274, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF01033 Somatomedin_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00645 Pept_C1, 1 hit
SM00201 SO, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q28625-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTGYKFFIF FYLAKEIWTE KQFQKQVDLA SYSSRNHSIL EGTRFKRSIF
60 70 80 90 100
QGQYCRSLGC CEGRNDNCVT QFYEANALCY CDKFCERENS DCCPDYKSFC
110 120 130 140 150
QEEKEWLPHT QSWYPEGCIR DGLHYEEGSV IKENCNSCTC SGQHWKCSQH
160 170 180 190 200
VCLVLPELIE HINKGDYGWT AQNYSQFWGM TLEEGFRFRL GTLPPSPVLL
210 220 230 240 250
SMNEMRATLP ETTDLPEFFI AFLQMAWMDS WAIGSKNCAA SWAFSTASVA
260 270 280 290 300
ADRIAIQSNG RYTANLSPQN LISCCAKNRH GCNSGSIDRA WWYLRKRGLV
310 320 330 340 350
SHACYPLFKD QNISNNTCAM TSKADGRGKR HATRPCPNNI EKSNRIYQCS
360 370 380 390 400
PPYRVSSNET EIMKEIMQNG PVQAIMQVHE DFFHYKTGIY RHVISTNEES
410 420 430 440 450
EKYRKLQTHA VKLTGWGTLK GARGQKEKFW IAANSWGKSW GENGYFRILR
460 470
GVNESDIEKL IIAAWGQLTS SDEP
Length:474
Mass (Da):54,522
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46AAF48FB7C29D1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U24270 mRNA Translation: AAC48477.1

Protein sequence database of the Protein Information Resource

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PIRi
A57480

NCBI Reference Sequences

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RefSeqi
NP_001076255.1, NM_001082786.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100009584

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ocu:100009584

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24270 mRNA Translation: AAC48477.1
PIRiA57480
RefSeqiNP_001076255.1, NM_001082786.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC01.973

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009584
KEGGiocu:100009584

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27283

Phylogenomic databases

eggNOGiKOG1544 Eukaryota
ENOG410YN9K LUCA
HOGENOMiHOG000241342
OrthoDBi1436535at2759

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C
IPR001212 Somatomedin_B_dom
IPR033164 TINAG
PANTHERiPTHR12411:SF274 PTHR12411:SF274, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF01033 Somatomedin_B, 1 hit
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SM00201 SO, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ28625_RABIT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28625
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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