UniProtKB - Q28623 (SLMAP_RABIT)
Protein
Sarcolemmal membrane-associated protein
Gene
SLMAP
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
May play a role during myoblast fusion.By similarity
GO - Biological processi
- muscle contraction Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Sarcolemmal membrane-associated proteinShort name: Sarcolemmal-associated protein |
Gene namesi | Name:SLMAP Synonyms:SLAP |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centrosome By similarity
Plasma membrane
- sarcolemma 1 Publication; Single-pass type IV membrane protein 1 Publication
Note: Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes (By similarity). Localizes to the centrosomes in a microtubule- dependent manner (By similarity).By similarity
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: InterPro
Plasma Membrane
- sarcolemma Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 745 | CytoplasmicSequence analysisAdd BLAST | 745 | |
Transmembranei | 746 – 766 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 767 – 771 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259664 | 1 – 771 | Sarcolemmal membrane-associated proteinAdd BLAST | 771 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | PhosphoserineBy similarity | 1 | |
Modified residuei | 431 | PhosphoserineBy similarity | 1 | |
Modified residuei | 435 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinExpressioni
Tissue specificityi
Expressed in heart (at protein level). Expressed in heart, skeletal muscle, smooth muscle, kidney, spleen, pancreas and brain.2 Publications
Gene expression databases
ExpressionAtlasi | Q28623, baseline |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with myosin.
By similarity1 PublicationProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000018690 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 85 | FHAPROSITE-ProRule annotationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 163 | Necessary for targeting to centrosomesBy similarityAdd BLAST | 163 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 167 – 202 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 230 – 381 | Sequence analysisAdd BLAST | 152 | |
Coiled coili | 452 – 742 | Sequence analysisAdd BLAST | 291 |
Sequence similaritiesi
Belongs to the SLMAP family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3872, Eukaryota |
GeneTreei | ENSGT00940000157660 |
InParanoidi | Q28623 |
OrthoDBi | 902273at2759 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR001363, Prot_inh_fetuin_CS IPR030498, SLMAP IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR15715:SF22, PTHR15715:SF22, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketNote: Some isoforms exhibit tissue specific expression.
This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q28623-1) [UniParc]FASTAAdd to basket
Also known as: Sarcolemmal-associated protein-3, SLAP3
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV
60 70 80 90 100
LSRNHALVWF DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG
110 120 130 140 150
DIIQFGVDVT ENTRKVTHGC IVSTIKLFLP DGMEARLRSD VIHAPLPSPV
160 170 180 190 200
DKVAANTPSM YSQELFQLSQ YLQEALHREQ MLEQKLATLQ RLLAITQEAS
210 220 230 240 250
DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL IALQEDKHNY
260 270 280 290 300
ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL
310 320 330 340 350
RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME
360 370 380 390 400
EKEQELQAKI EALQADNDFT NERLTALQEH LLSKSGGDCT FIHQFIECQK
410 420 430 440 450
KLIVEGHLTK VVEETKLAKE NQARAKESDL SDTLSPSKEK SSDDTTDAQM
460 470 480 490 500
DEQDLNESLA KVSLLKALLE EERKAYRNQV EESSKQIQVL QAQLQRLHMD
510 520 530 540 550
IENLREEKDN EITSTRDELL SARDEILLLH QAAEKAASER DTDIASLQEE
560 570 580 590 600
LKKVRAELER WRKAASEYEK EVTSLQSSFQ LRCQQCEDQQ KEEATRLQGE
610 620 630 640 650
LEKLRKEWNV LETECHSLKK ENVLLSSELQ RQEKELHNSQ KQSLELTSDL
660 670 680 690 700
SILQMTRKEL ENQMGSLKEQ HLRDSADLKI LLSKAENQAK DVQKEYEKTQ
710 720 730 740 750
TVLSELKLKF EMTEQEKQSI TDELKQCKDN LKLLQEKGNN NKPWPWMPML
760 770
AALVAVTAIV LYVPGLARAS P
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9C468 | A0A5F9C468_RABIT | Sarcolemmal membrane-associated pro... | 804 | Annotation score: | |||
A0A5F9CJ71 | A0A5F9CJ71_RABIT | Sarcolemmal membrane-associated pro... | 842 | Annotation score: | |||
A0A5F9D384 | A0A5F9D384_RABIT | Sarcolemmal membrane-associated pro... | 825 | Annotation score: | |||
A0A5F9D7P7 | A0A5F9D7P7_RABIT | Sarcolemmal membrane-associated pro... | 812 | Annotation score: | |||
A0A5F9DAB6 | A0A5F9DAB6_RABIT | Sarcolemmal membrane-associated pro... | 821 | Annotation score: | |||
A0A5F9DBG1 | A0A5F9DBG1_RABIT | Sarcolemmal membrane-associated pro... | 856 | Annotation score: | |||
A0A5F9DJY0 | A0A5F9DJY0_RABIT | Sarcolemmal membrane-associated pro... | 842 | Annotation score: | |||
A0A5F9DLL6 | A0A5F9DLL6_RABIT | Sarcolemmal membrane-associated pro... | 838 | Annotation score: | |||
A0A5F9DNK9 | A0A5F9DNK9_RABIT | Sarcolemmal membrane-associated pro... | 859 | Annotation score: |
Sequence cautioni
The sequence AAA65597 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021519 | 1 – 449 | Missing in isoform 3. 1 PublicationAdd BLAST | 449 | |
Alternative sequenceiVSP_021520 | 1 – 408 | Missing in isoform 4. 1 PublicationAdd BLAST | 408 | |
Alternative sequenceiVSP_021521 | 1 – 348 | Missing in isoform 2. 1 PublicationAdd BLAST | 348 | |
Alternative sequenceiVSP_021522 | 380 – 400 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_021523 | 409 – 466 | TKVVE…VSLLK → MDEQDLNESLAKVSLLKDDL QGAQSETEAKQEIQHLRKEL IEAQELARASKQKCFELQ in isoform 4. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_021524 | 742 – 771 | KPWPW…ARASP → PSILQPVPAVFIGLFLAFLF WCFGPLW in isoform 4. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21155 mRNA Translation: AAA65598.1 U21156 mRNA Translation: AAA65596.1 U21157 mRNA Translation: AAA65597.1 Different initiation. AF304449 mRNA Translation: AAG41948.1 |
RefSeqi | XP_008258693.1, XM_008260471.2 [Q28623-1] XP_017199132.1, XM_017343643.1 [Q28623-3] |
Genome annotation databases
Ensembli | ENSOCUT00000022997; ENSOCUP00000018690; ENSOCUG00000000827 [Q28623-1] |
GeneIDi | 100009199 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21155 mRNA Translation: AAA65598.1 U21156 mRNA Translation: AAA65596.1 U21157 mRNA Translation: AAA65597.1 Different initiation. AF304449 mRNA Translation: AAG41948.1 |
RefSeqi | XP_008258693.1, XM_008260471.2 [Q28623-1] XP_017199132.1, XM_017343643.1 [Q28623-3] |
3D structure databases
SMRi | Q28623 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000018690 |
Genome annotation databases
Ensembli | ENSOCUT00000022997; ENSOCUP00000018690; ENSOCUG00000000827 [Q28623-1] |
GeneIDi | 100009199 |
Organism-specific databases
CTDi | 7871 |
Phylogenomic databases
eggNOGi | KOG3872, Eukaryota |
GeneTreei | ENSGT00940000157660 |
InParanoidi | Q28623 |
OrthoDBi | 902273at2759 |
Gene expression databases
ExpressionAtlasi | Q28623, baseline |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR001363, Prot_inh_fetuin_CS IPR030498, SLMAP IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR15715:SF22, PTHR15715:SF22, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SLMAP_RABIT | |
Accessioni | Q28623Primary (citable) accession number: Q28623 Secondary accession number(s): Q28621, Q28622, Q9GK69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | August 12, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families