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Protein
Submitted name:

Glomerular epithelial protein 1

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1107Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • phosphatase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Glomerular epithelial protein 1Imported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei819 – 843HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500420359130 – 1187Sequence analysisAdd BLAST1158

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ28613
SMRiQ28613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini328 – 424Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini434 – 530Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini531 – 627Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini630 – 723Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini724 – 816Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini909 – 1166Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1083 – 1157TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
HOGENOMiHOG000115792
HOVERGENiHBG053763
KOiK18035

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q28613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLPTRARG RRRLLPLLWL FVLLKTAAAF HVTVRDDNSI VVSLEASDVI
60 70 80 90 100
SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFKANYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
TRVNISYWEG KAFRTMLYKD FFKGKTVFNH WLPGICYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RIVNLNKNNW EEQSGSFPEE
260 270 280 290 300
SFMRSPETIE KDRIFHFTEE TPEPSGNISS GWPDFNSSDY ETTSQPYWWD
310 320 330 340 350
SASATPESED EFVSVLPMEY ENNNTLSEAE KPTPAPFSFF PVQMILSWLP
360 370 380 390 400
PKPPTAFDGF HIHIEREENF TEYSTVDEEA HEFVAELKEP GKYKLSVTTF
410 420 430 440 450
SASGSCETRE SQSAKSLSFY ISPTGEWIEE LTEKPQHVSV HVLSSTTALM
460 470 480 490 500
SWTSSQENYN STIVSVVSLT CQKQKESQRL EKQYCTQVNS SKRIIENLVP
510 520 530 540 550
GAQYQVVMYL RKGPLIGPPS DPVTFAIVPT GIKDLMLYPL GPTAVVLSWT
560 570 580 590 600
RPYLGVFRKY VVEMFYFNPA TMTSEWTTYY EIAATVSLTA SVRIANLLPA
610 620 630 640 650
WYYNFRVTMV TWGDPELSCC DSSTISFITA PVAPEITSVE YFNSLLYISW
660 670 680 690 700
TYGDDTTDLS HSRMLHWMVV AEGKKKIKKS VTRNVMTAIL SLPPGDIYNL
710 720 730 740 750
SVTACTERGS NTSMLRLVKL EPAPPKSLFA VNKTQTSVTL LWVEEGVADF
760 770 780 790 800
FEVFCQQVGS GLETKLQEPV AVSSHVVTIS SLLPATAYNC SVTSFSHDSP
810 820 830 840 850
SVPTFIAVST MVTEMNPNVV VISVLAILST LLIGLLLVTL IILRKKHLQM
860 870 880 890 900
ARECGAGTFV NFASLERDGK LPYNWSKNGL KKRKLTNPVQ LDDFDAYIKD
910 920 930 940 950
MAKDSDYKFS LQFEELKLIG LDIPHFAADL PLNRCKNRYT NILPYDFSRV
960 970 980 990 1000
RLLSMNEEEG ADYINANYIP GYNSPQEYIA TQGPLPETRN DFWKMVLQQK
1010 1020 1030 1040 1050
SQMIVMLTQC NEKRRVKCDH YWPFTEEPIA YGDITVEMIS EEEQDDWAHR
1060 1070 1080 1090 1100
HFRINYADEM QDVMHFNYTA WPDHGVPTAN AAESILQFVH MVRQQATKSK
1110 1120 1130 1140 1150
GPMIIHCSAG VGRTGTFIAL DRLLQHIRDH EFVDILGLVS EMRSYRMSMV
1160 1170 1180
QTEEQYIFIH QCVQLMWMKK KQQFCISDVI YENVSKS
Length:1,187
Mass (Da):135,047
Last modified:November 1, 1996 - v1
Checksum:i68541F9A796A51B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09490 mRNA Translation: AAA61709.1
PIRiA53661
RefSeqiNP_001076219.1, NM_001082750.1
UniGeneiOcu.2018

Genome annotation databases

GeneIDi100009529
KEGGiocu:100009529

Similar proteinsi

Entry informationi

Entry nameiQ28613_RABIT
AccessioniPrimary (citable) accession number: Q28613
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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