UniProtKB - Q28612 (UD14_RABIT)
Protein
UDP-glucuronosyltransferase 1A4
Gene
Ugt1a4
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis. Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption.By similarity
Catalytic activityi
- EC:2.4.1.17By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- glucuronosyltransferase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucuronosyltransferase 1A4Curated (EC:2.4.1.17By similarity)Short name: UGT1A4 Alternative name(s): UDP-glucuronosyltransferase 1-4 Short name: UDPGT 1-4 Short name: UGT1*4 Short name: UGT1-04 Short name: UGT1.4 |
Gene namesi | Name:Ugt1a4 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 490 – 506 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000036015 | 28 – 532 | UDP-glucuronosyltransferase 1A4Add BLAST | 505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Homodimers. Homooligomer.
Interacts with UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the UDP-glycosyltransferase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q28612 |
OrthoDBi | 508327at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: UGT1A4 is one of the isoforms produced at the UGT1A complex locus. The UGT1A complex locus produces different isoforms based on alternative use of promoters, first exons and terminal exons.By similarity
Isoform 1 (identifier: Q28612-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLGVWITLW RLVRLLLLLC VLPWAEGGKV LVVPMDGSPW LSLREVVRDV
60 70 80 90 100
HARGHQVLVL GPEVTMHIKG EDFFTLQTYA TPYSKEEFDQ LMQRNYQMIF
110 120 130 140 150
KPQHSLKTLL ETMENLKKFS MLCSRSCWEL LHNKPLIKHL NESSFDVVLT
160 170 180 190 200
DPLDLCGALL AKYLSVPSVF LLRFILCDLD FEGTQCPNPS SYIPRMLTMN
210 220 230 240 250
SDHMSFLQRV KNMLYPLMMK YTCHISYDPY ASLASELFQR EVSLVDILSH
260 270 280 290 300
ASVWLFREDF VLDYPRPIMP NMVFIGGINC ANRKPLSQEF EAYVNASGEH
310 320 330 340 350
GIVVFSLGSM VSEIPEKKAM EIADALGKIP QTVLWRYTGS RPSNLAKNTY
360 370 380 390 400
LVKWLPQNVL LGHPKTRAFI THSGSHGIYE GICNGVPMVM LPLFGDQMDN
410 420 430 440 450
AKRIETRGAG VTLNVLEMTS DDLANALKTV INDKSYKENI MRLSSLHKDR
460 470 480 490 500
PVEPLDLAVF WVEFVMRHKG AAPRPAAHDL TWYQYHSLDV IGFLLAIVLT
510 520 530
VAFVTFKCCA FAWGKCFGKK GRVKKAHKSK VH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09101 mRNA Translation: AAA51868.1 |
RefSeqi | NP_001082791.1, NM_001089322.1 [Q28612-1] |
Genome annotation databases
GeneIDi | 100038310 |
KEGGi | ocu:100038310 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09101 mRNA Translation: AAA51868.1 |
RefSeqi | NP_001082791.1, NM_001089322.1 [Q28612-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Genome annotation databases
GeneIDi | 100038310 |
KEGGi | ocu:100038310 |
Organism-specific databases
CTDi | 100038310 |
Phylogenomic databases
InParanoidi | Q28612 |
OrthoDBi | 508327at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UD14_RABIT | |
Accessioni | Q28612Primary (citable) accession number: Q28612 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families