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Protein

Interferon alpha/beta receptor 1

Gene

IFNAR1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 1
Short name:
IFN-R-1
Short name:
IFN-alpha/beta receptor 1
Alternative name(s):
Type I interferon receptor 1
Gene namesi
Name:IFNAR1
Synonyms:IFNAR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 437ExtracellularSequence analysisAdd BLAST413
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 560CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001100425 – 560Interferon alpha/beta receptor 1Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 84By similarity
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi199 ↔ 220By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi283 ↔ 291By similarity
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi404 ↔ 427By similarity
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi464S-palmitoyl cysteineBy similarity1
Modified residuei467Phosphotyrosine; by TYK2By similarity1
Modified residuei482Phosphotyrosine; by TYK2By similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei536PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated, leading to its internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex; this prevents receptor internalization and degradation. Probable ubiquitination sites have been identified in human, but are poorly conserved across species.By similarity
Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination. Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.By similarity
Palmitoylation at Cys-464 is required for the activation of STAT1 and STAT2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ28589

Expressioni

Tissue specificityi

Expressed in the endometrium. Expressed in all tissues examined except conceptus at day 15 of pregnancy.2 Publications

Interactioni

Subunit structurei

Heterodimer with IFNAR2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-467. Interacts with TYK2. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ28589
SMRiQ28589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 226Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini231 – 329Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini333 – 433Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni492 – 501Important for interaction with TYK2By similarity10

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052126

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR016669 Interferon_alpha/beta_rcpt-1
PfamiView protein in Pfam
PF09294 Interfer-bind, 2 hits
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLLGATTL MLVAGRWVLP AASGEANLKS ENVEIHIIDD NFFLKWNSSS
60 70 80 90 100
ESVRNVTFSA DYQILGTDNW KKLPGCQHIT SSKCNFSSVE LKDVFEKIEL
110 120 130 140 150
RIRAEEGNNT STWYEVEPFV PFLKAQIGPP DVHLEAEDKA IILSISPPGT
160 170 180 190 200
EDSIMWALDR SSFRYSVVIW KNSSSLEERT ETVYPEDKIY KLSPEITYCL
210 220 230 240 250
KVKAELRLQS RVGCYSPVYC INTTERHKVP SPENVQINVD NQAYVLKWDY
260 270 280 290 300
PYESTTFQAQ WLRAFLKKIP GKHSNKWKQI PNCENVTTTH CVFPRDIFSM
310 320 330 340 350
GIYYVRVRAS NGNGTSFWSE EKEFNTEVKP IIFPPVISMK SITDDSLHVS
360 370 380 390 400
VSASEESENM SVNQLYPLVY EVIFWENTSN AERKVLEKRT DFTFPNLKPL
410 420 430 440 450
TVYCVKARAL IENDRWNKGS SYSDTVCEKT KPGNTSKTWL IAGICTALFS
460 470 480 490 500
ILVVIYVVRV FLRCVKYVFF PSSKPPSSVD QYFSDQPLRN LLLSTSEEQT
510 520 530 540 550
ERCFIIENAS IITEIEETNE VAEVHEEYNS QASQDSGNYS NEDENSGSKI
560
SEEFLQQDSV
Length:560
Mass (Da):63,918
Last modified:November 1, 1997 - v1
Checksum:iE7198A1905D4805C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352S → G in AAB84231 (PubMed:9348203).Curated1
Sequence conflicti522A → D in AAB84231 (PubMed:9348203).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95939 mRNA Translation: CAA65183.1
U65978 mRNA Translation: AAB84231.1
UniGeneiOar.837

Similar proteinsi

Entry informationi

Entry nameiINAR1_SHEEP
AccessioniPrimary (citable) accession number: Q28589
Secondary accession number(s): Q95206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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