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Protein

Disintegrin and metalloproteinase domain-containing protein 2

Gene

ADAM2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Protein family/group databases

MEROPSiM12.950

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 2
Short name:
ADAM 2
Alternative name(s):
Fertilin subunit beta
PH-30
Short name:
PH30
PH30-beta
Gene namesi
Name:ADAM2
Synonyms:FTNB
ORF Names:QtsA-17331
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 686ExtracellularSequence analysisAdd BLAST670
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 735CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002904417 – 174By similarityAdd BLAST158
ChainiPRO_0000029045175 – 735Disintegrin and metalloproteinase domain-containing protein 2Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi287 ↔ 370By similarity
Disulfide bondi329 ↔ 354By similarity
Disulfide bondi331 ↔ 336By similarity
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi445 ↔ 465By similarity
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi616 ↔ 627By similarity
Disulfide bondi621 ↔ 633By similarity
Disulfide bondi635 ↔ 644By similarity
Modified residuei729PhosphoserineBy similarity1

Post-translational modificationi

The signal and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ28478

Expressioni

Tissue specificityi

Expressed specifically in testis.

Interactioni

Subunit structurei

Heterodimer with ADAM1/fertilin subunit alpha.

Structurei

3D structure databases

ProteinModelPortaliQ28478
SMRiQ28478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 375Peptidase M12BPROSITE-ProRule annotationAdd BLAST198
Domaini384 – 473DisintegrinPROSITE-ProRule annotationAdd BLAST90
Domaini612 – 645EGF-likePROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi476 – 606Cys-richAdd BLAST131

Domaini

A tripeptide motif (FDE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.By similarity

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG103628
KOiK06833

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033958 ADAM2
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF108 PTHR11905:SF108, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRVLFLLSG LGGLWMDSNF DSLPVQITVP EKIRSIIKEE IESQVSYKIV
60 70 80 90 100
IEGKPYTANL MQKNFLSHNF RVYSYNGTGI MKPLDQDFQN FCHYQGYIEG
110 120 130 140 150
YPKSVAMVST CTGLRGLLQF ENVSYGIEPL ESSVGFEHVI YQVKHKKADV
160 170 180 190 200
SLYNEKDIES RDLSFKLQSI EPQKDFAKYI EMHVVVEKQL YNHMGSGTTV
210 220 230 240 250
VTQKIFQLIG LTNAIFVSLN ITVILSSLEL WIDENKIATT GDAKELLHTF
260 270 280 290 300
LRWKRSYLVL RPHDVAFLLV YREKSNYVGA TFQGKMCDAN YAGGVLLHPR
310 320 330 340 350
TISLESLAVI LAQLLSLSMG IPYDDINQCQ CSAAVCIMNP EAIHFSGVKI
360 370 380 390 400
FSNCSIEDFA HFISKQKSQC LHNQPRLDPF FKQQAVCGNA KLEAGEECDC
410 420 430 440 450
GTQQNCFLLG AKCCDTATCR FKAGSNCAEG PCCENCLFMS QERVCRPSFD
460 470 480 490 500
ECDLPEYCNG TSASCPENHF IQTGHPCGPN QWVCIDGVCM NGDKQCMDTF
510 520 530 540 550
GGEAEFGPTE CYSYLNSKTD VSGNCGIGDS GYTQCEADNL QCGKLICKYA
560 570 580 590 600
GEFLLQIPRA TIIYANISGH LCVAVEFASD HEDSHKMWIK DGTSCGSNKV
610 620 630 640 650
CKNQRCVSSS YLGYDCTTDK CNHRGVCNNK KHCHCSASYL PPDCSVQSDT
660 670 680 690 700
SPGGSIDSGN FPLVAVPARL PERRHMENVY HSKPMRWPLF LFIPFFIIFC
710 720 730
VLIAIMVKVH FQRKKWRTED YSTDEQPESE SEPKG
Length:735
Mass (Da):82,372
Last modified:January 23, 2007 - v2
Checksum:iBE84BE1158C60B53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65F → S in BAE01208 (Ref. 3) Curated1
Sequence conflicti121E → G in BAE01208 (Ref. 3) Curated1
Sequence conflicti225L → P in BAE01208 (Ref. 3) Curated1
Sequence conflicti681H → Y in BAE01208 (Ref. 3) Curated1
Sequence conflicti723T → S in CAA54733 (PubMed:7741716).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77653 mRNA Translation: CAA54733.1
U33959 mRNA Translation: AAB52699.1
AB169114 mRNA Translation: BAE01208.1
PIRiG02937
RefSeqiNP_001270782.1, NM_001283853.1
UniGeneiMfa.3947

Genome annotation databases

GeneIDi102125672
KEGGimcf:102125672

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77653 mRNA Translation: CAA54733.1
U33959 mRNA Translation: AAB52699.1
AB169114 mRNA Translation: BAE01208.1
PIRiG02937
RefSeqiNP_001270782.1, NM_001283853.1
UniGeneiMfa.3947

3D structure databases

ProteinModelPortaliQ28478
SMRiQ28478
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.950

Proteomic databases

PRIDEiQ28478

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102125672
KEGGimcf:102125672

Organism-specific databases

CTDi2515

Phylogenomic databases

HOVERGENiHBG103628
KOiK06833

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033958 ADAM2
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF108 PTHR11905:SF108, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADAM2_MACFA
AccessioniPrimary (citable) accession number: Q28478
Secondary accession number(s): Q28472, Q4R6R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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