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Protein

Endothelin-1

Gene

EDN1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Gene namesi
Name:EDN1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000146840‹1 – ›76Endothelin-1Add BLAST›76

Keywords - PTMi

Cleavage on pair of basic residues

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 44Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
SMARTiView protein in SMART
SM00272 END, 1 hit
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Q28469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VVPYGLGSPR SKRALENLLP TKATDRENRC QCASQKDKKC WNFCQAGKEL
60 70
RAKDLMEKGW NNHKKGKDCS KLGKKC
Length:76
Mass (Da):8,625
Last modified:November 1, 1997 - v1
Checksum:iBA403AB9DBA654C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20579 Genomic DNA Translation: AAA62438.1
PIRiG02934

Entry informationi

Entry nameiEDN1_MACFA
AccessioniPrimary (citable) accession number: Q28469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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