UniProtKB - Q283N4 (URAD_MOUSE)
Protein
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Gene
Urad
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.By similarity1 Publication
Catalytic activityi
- EC:4.1.1.97
: urate degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes (S)-allantoin from urate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Uricase (Uox), Uricase (Uox), Urate oxidase (Uox), Uricase (Uox), Uricase (Uox), Uricase (Uox)
- 5-hydroxyisourate hydrolase (Urah)
- Parahox neighbor (Urad), 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (Urad)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 67 | Proton donorBy similarity | 1 | |
Binding sitei | 68 | Substrate; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- carboxy-lyase activity Source: MGI
GO - Biological processi
- allantoin biosynthetic process Source: InterPro
- purine nucleobase metabolic process Source: UniProtKB-KW
- urate catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Purine metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00394;UER00652 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC:4.1.1.97)Short name: OHCU decarboxylase Alternative name(s): Parahox neighbor Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase |
Gene namesi | Name:Urad Synonyms:Prhoxnb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3647519, Urad |
Subcellular locationi
Peroxisome
- Peroxisome Curated
Peroxisome
- peroxisome Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315241 | 1 – 178 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylaseAdd BLAST | 178 |
Proteomic databases
jPOSTi | Q283N4 |
MaxQBi | Q283N4 |
PaxDbi | Q283N4 |
PRIDEi | Q283N4 |
PTM databases
iPTMneti | Q283N4 |
PhosphoSitePlusi | Q283N4 |
SwissPalmi | Q283N4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000075543, Expressed in multi-cellular organism and 20 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098000 |
Miscellaneous databases
RNActi | Q283N4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 88 | Substrate bindingBy similarity | 5 | |
Regioni | 119 – 123 | Substrate bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the OHCU decarboxylase family.Curated
Phylogenomic databases
eggNOGi | KOG0848, Eukaryota |
GeneTreei | ENSGT00390000002395 |
HOGENOMi | CLU_092522_1_0_1 |
InParanoidi | Q283N4 |
OMAi | KICHLRL |
OrthoDBi | 1547390at2759 |
PhylomeDBi | Q283N4 |
TreeFami | TF323276 |
Family and domain databases
Gene3Di | 1.10.3330.10, 1 hit |
InterProi | View protein in InterPro IPR018020, OHCU_decarboxylase IPR017580, OHCU_decarboxylase-1 IPR036778, OHCU_decarboxylase_sf |
Pfami | View protein in Pfam PF09349, OHCU_decarbox, 1 hit |
SUPFAMi | SSF158694, SSF158694, 1 hit |
TIGRFAMsi | TIGR03164, UHCUDC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q283N4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMVKVNSMD FGEFVDVFGN IVEKCPLIAA AVWSQRPFSG LEDLENHFFA
60 70 80 90 100
FIDALPRSGQ EGILRCHPDL AGRDLQQGTL TAESQREQSQ AGLTSLDTDD
110 120 130 140 150
RLRLQQLNAQ YRERFGFPFV LAARLSDRAT VPRELARRLQ CQPESELRTA
160 170
LGEVKKISHL RLTDLLGAHS HSARVELP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ225767 mRNA Translation: ABB46374.1 BC152959 mRNA Translation: AAI52960.1 |
CCDSi | CCDS39399.1 |
RefSeqi | NP_001034767.1, NM_001039678.2 |
Genome annotation databases
Ensembli | ENSMUST00000100433; ENSMUSP00000098000; ENSMUSG00000075543 |
GeneIDi | 231903 |
KEGGi | mmu:231903 |
UCSCi | uc009aoa.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ225767 mRNA Translation: ABB46374.1 BC152959 mRNA Translation: AAI52960.1 |
CCDSi | CCDS39399.1 |
RefSeqi | NP_001034767.1, NM_001039678.2 |
3D structure databases
SMRi | Q283N4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098000 |
PTM databases
iPTMneti | Q283N4 |
PhosphoSitePlusi | Q283N4 |
SwissPalmi | Q283N4 |
Proteomic databases
jPOSTi | Q283N4 |
MaxQBi | Q283N4 |
PaxDbi | Q283N4 |
PRIDEi | Q283N4 |
Protocols and materials databases
DNASUi | 231903 |
Genome annotation databases
Ensembli | ENSMUST00000100433; ENSMUSP00000098000; ENSMUSG00000075543 |
GeneIDi | 231903 |
KEGGi | mmu:231903 |
UCSCi | uc009aoa.2, mouse |
Organism-specific databases
CTDi | 646625 |
MGIi | MGI:3647519, Urad |
Phylogenomic databases
eggNOGi | KOG0848, Eukaryota |
GeneTreei | ENSGT00390000002395 |
HOGENOMi | CLU_092522_1_0_1 |
InParanoidi | Q283N4 |
OMAi | KICHLRL |
OrthoDBi | 1547390at2759 |
PhylomeDBi | Q283N4 |
TreeFami | TF323276 |
Enzyme and pathway databases
UniPathwayi | UPA00394;UER00652 |
Miscellaneous databases
BioGRID-ORCSi | 231903, 2 hits in 17 CRISPR screens |
PROi | PR:Q283N4 |
RNActi | Q283N4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075543, Expressed in multi-cellular organism and 20 other tissues |
Family and domain databases
Gene3Di | 1.10.3330.10, 1 hit |
InterProi | View protein in InterPro IPR018020, OHCU_decarboxylase IPR017580, OHCU_decarboxylase-1 IPR036778, OHCU_decarboxylase_sf |
Pfami | View protein in Pfam PF09349, OHCU_decarbox, 1 hit |
SUPFAMi | SSF158694, SSF158694, 1 hit |
TIGRFAMsi | TIGR03164, UHCUDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | URAD_MOUSE | |
Accessioni | Q283N4Primary (citable) accession number: Q283N4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | April 4, 2006 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families