UniProtKB - Q28399 (ALDH1_ELEED)
Protein
Aldehyde dehydrogenase, cytosolic 1
Gene
ALDH1
Organism
Elephantulus edwardii (Cape long-eared elephant shrew)
Status
Functioni
Major component of the eye of elephant shrews, which in contrast to other mammals, possesses both a lens- and a non-lens class-1 aldehyde dehydrogenase 1. This eye-specific form is a structural protein of the lens and, in other part of the eye, serves as the major form of ALDH1. Can convert/oxidize retinaldehyde to retinoic acid.1 Publication
Catalytic activityi
- EC:1.2.1.3
: ethanol degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Aldehyde dehydrogenase, cytosolic 1 (ALDH1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 170 | Transition state stabilizer | 1 | |
Active sitei | 269 | Proton acceptor | 1 | |
Active sitei | 303 | Nucleophile | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 246 – 251 | NAD1 Publication | 6 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: UniProtKB-EC
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
- identical protein binding Source: CAFA
- NAD binding Source: CAFA
- retinal dehydrogenase activity Source: CAFA
- structural molecule activity Source: UniProtKB
GO - Biological processi
- ethanol catabolic process Source: UniProtKB-UniPathway
- retinal metabolic process Source: CAFA
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.2.1.36, 7360 |
UniPathwayi | UPA00780;UER00768 |
Protein family/group databases
MoonProti | Q28399 |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)Alternative name(s): ALDH class 1 ETA-crystallin |
Gene namesi | Name:ALDH1 |
Organismi | Elephantulus edwardii (Cape long-eared elephant shrew) |
Taxonomic identifieri | 28737 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Macroscelidea › Macroscelididae › Elephantulus |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056427 | 1 – 501 | Aldehyde dehydrogenase, cytosolic 1Add BLAST | 501 |
Expressioni
Tissue specificityi
Eye specific, with very high expression in the lens.
Interactioni
Subunit structurei
Homotetramer.
1 PublicationGO - Molecular functioni
- identical protein binding Source: CAFA
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q28399 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q28399 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
OrthoDBi | 500317at2759 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q28399-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSGMPDLP APLTNIKIQH TKLFINNEWH ESVSGKTFPV FNPATEEKIC
60 70 80 90 100
EVEEADKEDV DKAVKAAREA FQMGSPWRTM DASERGQLIY KLADLIERDR
110 120 130 140 150
LLLATLESIN AGKVFASAYL MDLDYCIKAL RYCAGWADKI QGRTIPVDGE
160 170 180 190 200
FFSYTRHEPI GVCGLIFPWN APMILLACKI GPALCCGNTV IVKPAEQTPL
210 220 230 240 250
TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTEV
260 270 280 290 300
GKMIQEAAAK SNLKRVTLEL GAKNPCIVFA DADLDSAVEF AHQGVFTNQG
310 320 330 340 350
QSCIAASKLF VEEAIYDEFV QRSVERAKKY VFGNPLTPGV NHGPQINKAQ
360 370 380 390 400
HNKIMELIES GKKEGAKLEC GGGPWGNKGY FIQPTVFSNV TDDMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSLDEVIKR ANNTYYGLVA GVFTKDLDKA VTVSSALQAG
460 470 480 490 500
TVWVNCYLAA SAQSPAGGFK MSGHGREMGE YGIHEYTEVK TVTMKISEKN
S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02483 mRNA Translation: AAB60268.1 |
RefSeqi | NP_001277088.1, NM_001290159.1 |
Genome annotation databases
GeneIDi | 102867337 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02483 mRNA Translation: AAB60268.1 |
RefSeqi | NP_001277088.1, NM_001290159.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1O9J | X-ray | 2.40 | A/B/C/D | 1-501 | [»] | |
1PEJ | model | - | A | 1-501 | [»] | |
SMRi | Q28399 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MoonProti | Q28399 |
Genome annotation databases
GeneIDi | 102867337 |
Organism-specific databases
CTDi | 102867337 |
Phylogenomic databases
OrthoDBi | 500317at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00780;UER00768 |
BRENDAi | 1.2.1.36, 7360 |
Miscellaneous databases
EvolutionaryTracei | Q28399 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDH1_ELEED | |
Accessioni | Q28399Primary (citable) accession number: Q28399 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | October 7, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families