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Entry version 136 (16 Jan 2019)
Sequence version 2 (11 Jan 2001)
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Protein

von Willebrand factor

Gene

VWF

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VWF
Synonyms:F8VWF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in VWF are the cause of von Willebrand disease (VWD) in the Scottish Terrier. VWD is characterized by frequent bleeding. Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002268023 – 763By similarityAdd BLAST741
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000022681764 – 2813von Willebrand factorAdd BLAST2050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 2811By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi767 ↔ 808By similarity
Disulfide bondi776 ↔ 804By similarity
Disulfide bondi810 ↔ 821By similarity
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi867 ↔ 996By similarity
Disulfide bondi889 ↔ 1031By similarity
Disulfide bondi898 ↔ 993By similarity
Disulfide bondi914 ↔ 921By similarity
Disulfide bondi1060 ↔ 1084By similarity
Disulfide bondi1071 ↔ 1111By similarity
Disulfide bondi1089 ↔ 1091By similarity
Disulfide bondi1126 ↔ 1130By similarity
Disulfide bondi1149 ↔ 1169By similarity
Disulfide bondi1153 ↔ 1165By similarity
Disulfide bondi1196 ↔ 1199By similarity
Glycosylationi1231N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1234 ↔ 1237By similarity
Disulfide bondi1272 ↔ 1458By similarity
Glycosylationi1515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1669 ↔ 1670By similarity
Disulfide bondi1686 ↔ 1872By similarity
Disulfide bondi1879 ↔ 1904By similarity
Disulfide bondi1899 ↔ 1940Or C-1899 with C-1942PROSITE-ProRule annotation
Disulfide bondi1927 ↔ 2088By similarity
Disulfide bondi1950 ↔ 2085By similarity
Disulfide bondi1972 ↔ 2123By similarity
Disulfide bondi1993 ↔ 2001By similarity
Glycosylationi2223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2585N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2724 ↔ 2774By similarity
Disulfide bondi2739 ↔ 2788By similarity
Disulfide bondi2750 ↔ 2804By similarity
Disulfide bondi2754 ↔ 2806By similarity
Glycosylationi2790N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds.By similarity
N- and O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28295

PRoteomics IDEntifications database

More...
PRIDEi
Q28295

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimeric. Interacts with F8.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9615.ENSCAFP00000022453

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q28295

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28295

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 240VWFD 1PROSITE-ProRule annotationAdd BLAST207
Domaini295 – 348TIL 1Add BLAST54
Domaini387 – 598VWFD 2PROSITE-ProRule annotationAdd BLAST212
Domaini652 – 707TIL 2Add BLAST56
Domaini776 – 827TIL 3Add BLAST52
Domaini866 – 1074VWFD 3PROSITE-ProRule annotationAdd BLAST209
Domaini1146 – 1196TIL 4Add BLAST51
Domaini1277 – 1453VWFA 1PROSITE-ProRule annotationAdd BLAST177
Domaini1498 – 1665VWFA 2PROSITE-ProRule annotationAdd BLAST168
Domaini1691 – 1871VWFA 3PROSITE-ProRule annotationAdd BLAST181
Domaini1949 – 2153VWFD 4PROSITE-ProRule annotationAdd BLAST205
Domaini2255 – 2328VWFC 1PROSITE-ProRule annotationAdd BLAST74
Domaini2429 – 2495VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini2580 – 2645VWFC 3PROSITE-ProRule annotationAdd BLAST66
Domaini2724 – 2812CTCKPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni764 – 787Amino-terminalAdd BLAST24
Regioni788 – 833E1Add BLAST46
Regioni826 – 853CXAdd BLAST28
Regioni2216 – 2261E2Add BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi531 – 533Cell attachment siteSequence analysis3
Motifi698 – 700Cell attachment siteSequence analysis3
Motifi2507 – 2509Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The propeptide is required for multimerization of vWF and for its targeting to storage granules.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR8A Eukaryota
ENOG41100RZ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169747

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004380

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q28295

KEGG Orthology (KO)

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KOi
K03900

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF361 PTHR11339:SF361, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 4 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 5 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28295-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPTRLVRVL LALALILPGK LCTKGTVGRS SMARCSLFGG DFINTFDESM
60 70 80 90 100
YSFAGDCSYL LAGDCQEHSV SLIGGFQNGK RVSLSVYLGE FFDIHLFVNG
110 120 130 140 150
TMLQGTQSIS MPYASNGLYL EAEAGYYKLS SEAYGFVARI DGNGNFQVLL
160 170 180 190 200
SDRYFNKTCG LCGNFNIFAE DDFRTQEGTL TSDPYDFANS WALSSGEQRC
210 220 230 240 250
KRVSPPSSPC NVSSDEVQQV LWEQCQLLKS ASVFARCHPL VDPEPFVALC
260 270 280 290 300
ERTLCTCVQG MECPCAVLLE YARACAQQGI VLYGWTDHSV CRPACPAGME
310 320 330 340 350
YKECVSPCTR TCQSLHVKEV CQEQCVDGCS CPEGQLLDEG HCVGSAECSC
360 370 380 390 400
VHAGQRYPPG ASLLQDCHTC ICRNSLWICS NEECPGECLV TGQSHFKSFD
410 420 430 440 450
NRYFTFSGVC HYLLAQDCQD HTFSVVIETV QCADDLDAVC TRSVTVRLPG
460 470 480 490 500
HHNSLVKLKH GGGVSMDGQD IQIPLLQGDL RIQHTVMASV RLSYGEDLQM
510 520 530 540 550
DWDGRGRLLV TLSPAYAGKT CGLCGNYNGN RGDDFVTPAG LAEPLVEDFG
560 570 580 590 600
NAWKLLGACE NLQKQHRDPC SLNPRQARFA EEACALLTSS KFEPCHRAVG
610 620 630 640 650
PQPYVQNCRY DVCSCSDGRD CLCSAVANYA AACARRGVHI AWREPGFCAL
660 670 680 690 700
SCPQGQVYLQ CGTPCNMTCR SLSYPEEDCN EVCLEGCFCP PGLYLDERGD
710 720 730 740 750
CVPKAQCPCY YDGEIFQPED IFSDHHTMCY CEDGFMHCTT SGGLGSLLPN
760 770 780 790 800
PVLSSPRSHR SKRSLSCRPP MVKLVCPADN PRAEGLECAK TCQNYDLQCM
810 820 830 840 850
STGCVSGCLC PQGMVRHENR CVALERCPCF HQGQEYAPGE TVKIDCNTCV
860 870 880 890 900
CRDRKWNCTD HVCDATCSAI GMAHYLTFDG LKYLFPGECQ YVLVQDYCGS
910 920 930 940 950
NPGTFRILVG NEGCSYPSVK CKKRVTILVE GGEIELFDGE VNVKKPMKDE
960 970 980 990 1000
THFEVVESGQ YVILLLGKAL SVVWDHRLSI SVTLKRTYQE QVCGLCGNFD
1010 1020 1030 1040 1050
GIQNNDFTSS SLQIEEDPVD FGNSWKVNPQ CADTKKVPLD SSPAVCHNNI
1060 1070 1080 1090 1100
MKQTMVDSSC RILTSDIFQD CNRLVDPEPF LDICIYDTCS CESIGDCTCF
1110 1120 1130 1140 1150
CDTIAAYAHV CAQHGKVVAW RTATFCPQNC EERNLHENGY ECEWRYNSCA
1160 1170 1180 1190 1200
PACPITCQHP EPLACPVQCV EGCHAHCPPG KILDELLQTC IDPEDCPVCE
1210 1220 1230 1240 1250
VAGRRLAPGK KIILNPSDPE HCQICHCDGV NFTCQACREP GSLVVPPTEG
1260 1270 1280 1290 1300
PIGSTTSYVE DTPEPPLHDF HCSRLLDLVF LLDGSSKLSE DEFEVLKVFV
1310 1320 1330 1340 1350
VGMMEHLHIS QKRIRVAVVE YHDGSHAYIE LKDRKRPSEL RRITSQVKYA
1360 1370 1380 1390 1400
GSEVASTSEV LKYTLFQIFG KIDRPEASRI ALLLMASQEP SRLARNLVRY
1410 1420 1430 1440 1450
VQGLKKKKVI VIPVGIGPHA SLKQIHLIEK QAPENKAFVF SGVDELEQRR
1460 1470 1480 1490 1500
DEIINYLCDL APEAPAPTQH PPMAQVTVGS ELLGVSSPGP KRNSMVLDVV
1510 1520 1530 1540 1550
FVLEGSDKIG EANFNKSREF MEEVIQRMDV GQDRIHVTVL QYSYMVTVEY
1560 1570 1580 1590 1600
TFSEAQSKGE VLQQVRDIRY RGGNRTNTGL ALQYLSEHSF SVSQGDREQV
1610 1620 1630 1640 1650
PNLVYMVTGN PASDEIKRMP GDIQVVPIGV GPHANVQELE KIGWPNAPIL
1660 1670 1680 1690 1700
IHDFEMLPRE APDLVLQRCC SGEGLQIPTL SPTPDCSQPL DVVLLLDGSS
1710 1720 1730 1740 1750
SIPASYFDEM KSFTKAFISR ANIGPRLTQV SVLQYGSITT IDVPWNVAYE
1760 1770 1780 1790 1800
KVHLLSLVDL MQQEGGPSQI GDALSFAVRY VTSEVHGARP GASKAVVILV
1810 1820 1830 1840 1850
TDVSVDSVDA AAEAARSNRV TVFPIGIGDR YSEAQLSSLA GPKAGSNMVR
1860 1870 1880 1890 1900
LQRIEDLPTV ATLGNSFFHK LCSGFDRVCV DEDGNEKRPG DVWTLPDQCH
1910 1920 1930 1940 1950
TVTCLPDGQT LLKSHRVNCD RGPRPSCPNG QPPLRVEETC GCRWTCPCVC
1960 1970 1980 1990 2000
MGSSTRHIVT FDGQNFKLTG SCSYVLFQNK EQDLEVILHN GACSPGAKET
2010 2020 2030 2040 2050
CMKSIEVKHD GLSVELHSDM QMTVNGRLVS IPYVGGDMEV NVYGTIMYEV
2060 2070 2080 2090 2100
RFNHLGHIFT FTPQNNEFQL QLSPRTFASK TYGLCGICDE NGANDFILRD
2110 2120 2130 2140 2150
GTVTTDWKAL IQEWTVQQLG KTCQPVPEEQ CPVSSSSHCQ VLLSELFAEC
2160 2170 2180 2190 2200
HKVLAPATFY AMCQPDSCHP KKVCEAIALY AHLCRTKGVC VDWRRANFCA
2210 2220 2230 2240 2250
MSCPPSLVYN HCEHGCPRLC EGNTSSCGDQ PSEGCFCPPN QVMLEGSCVP
2260 2270 2280 2290 2300
EEACTQCISE DGVRHQFLET WVPAHQPCQI CTCLSGRKVN CTLQPCPTAR
2310 2320 2330 2340 2350
APTCGPCEVA RLRQNAEQCC PEYECVCDLV SCDLPPVPPC EDGLQMTLTN
2360 2370 2380 2390 2400
PGECRPNFTC ACRKDECRRE SPPSCPPHRT LALRKTQCCD EYECACNCVN
2410 2420 2430 2440 2450
STVSCPLGYL ASAVTNDCGC TTTTCFPDKV CVHRGTIYPV GQFWEEACDV
2460 2470 2480 2490 2500
CTCTDLEDSV MGLRVAQCSQ KPCEDNCLSG FTYVLHEGEC CGRCLPSACE
2510 2520 2530 2540 2550
VVIGSPRGDA QSHWKNVGSH WASPDNPCLI NECVRVKEEV FVQQRNVSCP
2560 2570 2580 2590 2600
QLNVPTCPTG FQLSCKTSEC CPTCHCEPLE ACLLNGTIIG PGKSLMIDVC
2610 2620 2630 2640 2650
TTCRCTVQVG VISGFKLECR KTTCEACPLG YKEEKNQGEC CGRCLPIACT
2660 2670 2680 2690 2700
IQLRGGQIMT LKRDETIQDG CDSHFCKVNE RGEYIWEKRV TGCPPFDEHK
2710 2720 2730 2740 2750
CLAEGGKIMK IPGTCCDTCE EPECKDIIAK LQRVKVGDCK SEEEVDIHYC
2760 2770 2780 2790 2800
EGKCASKAVY SIHMEDVQDQ CSCCSPTQTE PMQVPLRCTN GSLIYHEILN
2810
AMQCRCSPRK CSK
Length:2,813
Mass (Da):309,719
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DF93E1E5E72F80C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70V → I in AAD04919 (PubMed:10668811).Curated1
Sequence conflicti266A → G in AAB93766 (PubMed:10961880).Curated1
Sequence conflicti280I → V in AAB93766 (PubMed:10961880).Curated1
Sequence conflicti409 – 411VCH → ICQ in AAB93766 (PubMed:10961880).Curated3
Sequence conflicti994G → A in AAB05549 (Ref. 1) Curated1
Sequence conflicti1021F → L in AAB93766 (PubMed:10961880).Curated1
Sequence conflicti2381L → P in AAB93766 (PubMed:10961880).Curated1
Sequence conflicti2406P → L in AAB93766 (PubMed:10961880).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L76227 mRNA Translation: AAB05549.1
U66246 mRNA Translation: AAB93766.2
AF099154 mRNA Translation: AAD04919.1
L16903 Genomic DNA Translation: AAA30903.1

NCBI Reference Sequences

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RefSeqi
NP_001002932.1, NM_001002932.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cfa.111

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
399544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:399544

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76227 mRNA Translation: AAB05549.1
U66246 mRNA Translation: AAB93766.2
AF099154 mRNA Translation: AAD04919.1
L16903 Genomic DNA Translation: AAA30903.1
RefSeqiNP_001002932.1, NM_001002932.1
UniGeneiCfa.111

3D structure databases

ProteinModelPortaliQ28295
SMRiQ28295
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022453

Protein family/group databases

MEROPSiI08.950

Proteomic databases

PaxDbiQ28295
PRIDEiQ28295

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399544
KEGGicfa:399544

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7450

Phylogenomic databases

eggNOGiENOG410IR8A Eukaryota
ENOG41100RZ LUCA
HOGENOMiHOG000169747
HOVERGENiHBG004380
InParanoidiQ28295
KOiK03900
OrthoDBi12226at2759

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR032361 VWA_N2
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 2 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 4 hits
PF00092 VWA, 3 hits
PF16164 VWA_N2, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 5 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVWF_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28295
Secondary accession number(s): Q28311, Q9TSI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: January 16, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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