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UniProtKB - Q28288 (STXB2_CANLF)
Protein
Syntaxin-binding protein 2
Gene
STXBP2
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Involved in the protein trafficking from the Golgi apparatus to the plasma membrane.
By similarityGO - Molecular functioni
- syntaxin-1 binding Source: GO_Central
- syntaxin-3 binding Source: UniProtKB
- syntaxin binding Source: GO_Central
GO - Biological processi
- intracellular protein transport Source: GO_Central
- neurotransmitter secretion Source: GO_Central
- neutrophil degranulation Source: UniProtKB
- vesicle docking involved in exocytosis Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-binding protein 2Alternative name(s): Protein unc-18 homolog 2 Short name: Unc18-2 Protein unc-18 homolog B Short name: Unc-18B |
Gene namesi | Name:STXBP2 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Lysosome
- azurophil granule Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- presynapse Source: GOC
- secretory granule Source: GO_Central
- specific granule Source: UniProtKB
- tertiary granule Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206280 | 1 – 593 | Syntaxin-binding protein 2Add BLAST | 593 |
Proteomic databases
PaxDbi | Q28288 |
PRIDEi | Q28288 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000018306, Expressed in brain and 55 other tissues |
Interactioni
Subunit structurei
Binds syntaxins 1A, 2, 3 but not 4.
By similarityGO - Molecular functioni
- syntaxin-1 binding Source: GO_Central
- syntaxin-3 binding Source: UniProtKB
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000027039 |
Family & Domainsi
Sequence similaritiesi
Belongs to the STXBP/unc-18/SEC1 family.Curated
Phylogenomic databases
eggNOGi | KOG1300, Eukaryota |
HOGENOMi | CLU_009210_2_0_1 |
InParanoidi | Q28288 |
OMAi | GEESKWM |
OrthoDBi | 725424at2759 |
TreeFami | TF313242 |
Family and domain databases
Gene3Di | 3.40.50.1910, 1 hit 3.40.50.2060, 1 hit 3.90.830.10, 1 hit |
InterProi | View protein in InterPro IPR043154, Sec-1-like_dom1 IPR043127, Sec-1-like_dom3a IPR001619, Sec1-like IPR027482, Sec1-like_dom2 IPR036045, Sec1-like_sf |
PANTHERi | PTHR11679, PTHR11679, 1 hit |
Pfami | View protein in Pfam PF00995, Sec1, 1 hit |
PIRSFi | PIRSF005715, VPS45_Sec1, 1 hit |
SUPFAMi | SSF56815, SSF56815, 1 hit |
i Sequence
Sequence statusi: Complete.
Q28288-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPSGLKEVV GEKILNGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI
60 70 80 90 100
LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FRGTPTFTYK
110 120 130 140 150
AAHIFFTDTC PEPLFTELSR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP
160 170 180 190 200
HSTYNLYCPF RVGERARQIE ALAQQIATLC ATLQEYPAIR YRKGPEVTAQ
210 220 230 240 250
LANAVLAKLN AFKADNPSLG EGPEKTRSQL LIVDRGADPV SPLLHELTFQ
260 270 280 290 300
AMAYDLLNIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS
310 320 330 340 350
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA
360 370 380 390 400
DDCMKHFKGS VEKLCGVEQD LAMGSDTEGE KIKDAMKLIV PVLLDAAVPA
410 420 430 440 450
YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN
460 470 480 490 500
PGGPGTSSRL ERRERLEPTY QLSRWTPVIK DVMEDAVEDR LDRKLWPFVS
510 520 530 540 550
DPAPTSSSQA AVSARFGHWH KNKAGVEMRA GPRLIIYVMG GVAMSEMRAA
560 570 580 590
YEVTRATDGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEDI ALP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41609 mRNA Translation: AAC00031.1 |
RefSeqi | NP_001003216.1, NM_001003216.1 |
Genome annotation databases
GeneIDi | 403880 |
KEGGi | cfa:403880 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41609 mRNA Translation: AAC00031.1 |
RefSeqi | NP_001003216.1, NM_001003216.1 |
3D structure databases
SMRi | Q28288 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000027039 |
Proteomic databases
PaxDbi | Q28288 |
PRIDEi | Q28288 |
Genome annotation databases
GeneIDi | 403880 |
KEGGi | cfa:403880 |
Organism-specific databases
CTDi | 6813 |
Phylogenomic databases
eggNOGi | KOG1300, Eukaryota |
HOGENOMi | CLU_009210_2_0_1 |
InParanoidi | Q28288 |
OMAi | GEESKWM |
OrthoDBi | 725424at2759 |
TreeFami | TF313242 |
Gene expression databases
Bgeei | ENSCAFG00000018306, Expressed in brain and 55 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1910, 1 hit 3.40.50.2060, 1 hit 3.90.830.10, 1 hit |
InterProi | View protein in InterPro IPR043154, Sec-1-like_dom1 IPR043127, Sec-1-like_dom3a IPR001619, Sec1-like IPR027482, Sec1-like_dom2 IPR036045, Sec1-like_sf |
PANTHERi | PTHR11679, PTHR11679, 1 hit |
Pfami | View protein in Pfam PF00995, Sec1, 1 hit |
PIRSFi | PIRSF005715, VPS45_Sec1, 1 hit |
SUPFAMi | SSF56815, SSF56815, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STXB2_CANLF | |
Accessioni | Q28288Primary (citable) accession number: Q28288 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families