UniProtKB - Q28172 (PRLR_BOVIN)
Protein
Prolactin receptor
Gene
PRLR
Organism
Bos taurus (Bovine)
Status
Functioni
This is a receptor for the anterior pituitary hormone prolactin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 211 | ZincBy similarity | 1 | |
Metal bindingi | 212 | ZincBy similarity | 1 |
GO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: GO_Central
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- leukemia inhibitory factor receptor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- peptide hormone binding Source: GO_Central
- prolactin receptor activity Source: GO_Central
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- oncostatin-M-mediated signaling pathway Source: GOC
- positive regulation of cell population proliferation Source: GO_Central
Keywordsi
Molecular function | Receptor |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Prolactin receptorShort name: PRL-R |
Gene namesi | Name:PRLR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: AgBase
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 237 | ExtracellularSequence analysisAdd BLAST | 213 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 581 | CytoplasmicSequence analysisAdd BLAST | 323 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000010975 | 25 – 581 | Prolactin receptorAdd BLAST | 557 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 46 | By similarity | ||
Glycosylationi | 59 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 75 ↔ 86 | By similarity | ||
Glycosylationi | 132 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q28172 |
PRIDEi | Q28172 |
Expressioni
Tissue specificityi
Expressed in all tissues examined; liver, peripheral blood lymphocytes, endometrium, corpus luteum, intestine, fetal thymus, fetal spleen, fetal liver and fetal brain.1 Publication
Interactioni
Subunit structurei
Interacts with SMARCA1.
Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
By similarityGO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: GO_Central
- cytokine binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014437 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 127 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 129 – 229 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 215 – 219 | WSXWS motif | 5 | |
Motifi | 267 – 275 | Box 1 motif | 9 |
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R22A, Eukaryota |
InParanoidi | Q28172 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS IPR033230, PRLR |
PANTHERi | PTHR23036:SF86, PTHR23036:SF86, 1 hit |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform Long (identifier: Q28172-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKENAASRVV FILLLFLSVS LLNGQSPPEK PKLVKCRSPG KETFTCWWEP
60 70 80 90 100
GADGGLPTNY TLTYHKEGET LIHECPDYKT GGPNSCYFSK KHTSIWKMYV
110 120 130 140 150
ITVNAINQMG ISSSDPLYVH VTYIVEPEPP ANLTLELKHP EDRKPYLWIK
160 170 180 190 200
WSPPTMTDVK SGWFIIQYEI RLKPEKATDW ETHFTLKQTQ LKIFNLYPGQ
210 220 230 240 250
KYLVQIRCKP DHGYWSEWSP ESSIQIPNDF PVKDTSMWIF VAILSAVICL
260 270 280 290 300
IMVWAVALKG YSMVTCILPP VPGPKIKGFD VHLLEKGKSE ELLRALESQD
310 320 330 340 350
FPPTSDCEDL LMEFIEVDDC EDQQLMPRPS KEHTEQGVKP MHLDLDSDSG
360 370 380 390 400
RGSCDSPSLL SEKCDEPQAH PSKFHTPEGP EKLENPETNL TCLQAPQSTS
410 420 430 440 450
VEGKIPYFLA NGPKSSTWPF PQPPSLYSPR YSYHNIADVC ELALGMAGTT
460 470 480 490 500
ATSLDQTDQH ALKASKTIET GREGKATKQR ESEGCSSKPD QDTVWPRPQD
510 520 530 540 550
KTPLISAKPL EYVEIHKVSQ DGVLALFPKQ NEKFGAPEAS KEYSKVSRVT
560 570 580
DSNILVLVPD PQAQNLTLLE EPAKKAPPAL P
Isoform Short (identifier: Q28172-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
286-296: KGKSEELLRAL → ISQPSRLVSMF
297-581: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | H → D AA sequence (PubMed:7738463).Curated | 1 | |
Sequence conflicti | 128 | E → D AA sequence (PubMed:7738463).Curated | 1 | |
Sequence conflicti | 137 | L → V AA sequence (PubMed:7738463).Curated | 1 | |
Sequence conflicti | 141 | E → H AA sequence (PubMed:7738463).Curated | 1 | |
Sequence conflicti | 156 – 157 | MT → IM AA sequence (PubMed:7738463).Curated | 2 | |
Sequence conflicti | 186 | L → P AA sequence (PubMed:7738463).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001718 | 286 – 296 | KGKSEELLRAL → ISQPSRLVSMF in isoform Short. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_001719 | 297 – 581 | Missing in isoform Short. 1 PublicationAdd BLAST | 285 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02549 mRNA Translation: AAA51417.1 AF027403 mRNA Translation: AAB83999.1 AF042780 Genomic DNA Translation: AAB97748.1 AF042780 Genomic DNA Translation: AAB97747.1 Sequence problems. |
PIRi | I45971 |
RefSeqi | NP_001034815.1, NM_001039726.2 [Q28172-1] NP_776580.1, NM_174155.3 [Q28172-2] |
Genome annotation databases
GeneIDi | 281422 |
KEGGi | bta:281422 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02549 mRNA Translation: AAA51417.1 AF027403 mRNA Translation: AAB83999.1 AF042780 Genomic DNA Translation: AAB97748.1 AF042780 Genomic DNA Translation: AAB97747.1 Sequence problems. |
PIRi | I45971 |
RefSeqi | NP_001034815.1, NM_001039726.2 [Q28172-1] NP_776580.1, NM_174155.3 [Q28172-2] |
3D structure databases
SMRi | Q28172 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014437 |
Proteomic databases
PaxDbi | Q28172 |
PRIDEi | Q28172 |
Genome annotation databases
GeneIDi | 281422 |
KEGGi | bta:281422 |
Organism-specific databases
CTDi | 5618 |
Phylogenomic databases
eggNOGi | ENOG502R22A, Eukaryota |
InParanoidi | Q28172 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS IPR033230, PRLR |
PANTHERi | PTHR23036:SF86, PTHR23036:SF86, 1 hit |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRLR_BOVIN | |
Accessioni | Q28172Primary (citable) accession number: Q28172 Secondary accession number(s): O18880, O46591 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families