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Entry version 157 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Neurexin-1

Gene

NRXN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi345Calcium 11 Publication1
Metal bindingi362Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi430Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi788Calcium 21 Publication1
Metal bindingi805Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi864Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi1199Calcium 3By similarity1
Metal bindingi1216Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1298Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1300Calcium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-1
Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRXN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 1454ExtracellularSequence analysisAdd BLAST1424
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1455 – 1475HelicalSequence analysisAdd BLAST21
Topological domaini1476 – 1530CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30By similarityAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001948931 – 1530Neurexin-1Add BLAST1500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi228 ↔ 243By similarity
Disulfide bondi245 ↔ 255By similarity
Disulfide bondi460 ↔ 496
Disulfide bondi666 ↔ 695
Disulfide bondi703 ↔ 714
Glycosylationi705O-linked (Glc...) serine1 Publication1
Disulfide bondi708 ↔ 723
Disulfide bondi725 ↔ 735
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi906 ↔ 914
Disulfide bondi1075 ↔ 1103
Disulfide bondi1110 ↔ 1121
Disulfide bondi1115 ↔ 1130
Disulfide bondi1132 ↔ 1142
Glycosylationi1246N-linked (GlcNAc...) asparagine3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.
O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28146

PRoteomics IDEntifications database

More...
PRIDEi
Q28146

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q28146

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer (PubMed:21552542, PubMed:21620717).

Interacts (via cytoplasmic C-terminus) with CASK (via the PDZ, SH3 and guanylate kinase-like domains) (By similarity).

Interacts (via cytoplasmic C-terminal region) with CASKIN1 and APBA1 (By similarity).

Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2, NLGN3 and NLGN4; these interactions are calcium-dependent.

Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3.

Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).

Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 (By similarity). Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom.

Interacts with SYT13 and SYTL1.

By similarity5 Publications

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59135N

Protein interaction database and analysis system

More...
IntActi
Q28146, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000033006

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28146

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q28146

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 212Laminin G-like 1PROSITE-ProRule annotationAdd BLAST182
Domaini213 – 256EGF-like 1PROSITE-ProRule annotationAdd BLAST44
Domaini299 – 496Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini503 – 695Laminin G-like 3PROSITE-ProRule annotationAdd BLAST193
Domaini699 – 736EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini741 – 914Laminin G-like 4PROSITE-ProRule annotationAdd BLAST174
Domaini928 – 1103Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1106 – 1143EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1149 – 1347Laminin G-like 6PROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1497 – 1523Interaction with CASKBy similarityAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1377 – 1380Poly-Thr4
Compositional biasi1462 – 1465Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230481

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28146

KEGG Orthology (KO)

More...
KOi
K07377

Database of Orthologous Groups

More...
OrthoDBi
35129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR001791 Laminin_G
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 16 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. In addition, there are at least five alternatively spliced sites, each of which may be spliced in up to seven different ways. Combinatorial splicing at each of these sites may lead to the generation of at least 96 isoforms. Experimental confirmation may be lacking for some isoforms.2 Publications
Isoform 1a (identifier: Q28146-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLTDTPVN DGAWHNVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSLALPVDSG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKEDN NVEGLAHLMM GDQGKEEYIA
310 320 330 340 350
TFKGSEYFCY DLSQNPIQSS SDEITLSFKT LQRNGLMLHT GKSADYVNLA
360 370 380 390 400
LKNGAVSLVI NLGSGAFEAL VEPVNGKFND NAWHDVKVTR NLRQTSGIGH
410 420 430 440 450
AMVNKLHCSV TISVDGILTT TGYTQEDYTM LGSDDFFYVG GSPSTADLPG
460 470 480 490 500
SPVSNNFMGC LKEVVYKNND VRLELSRLAK QGDPKMKIHG VVAFKCENVA
510 520 530 540 550
TLDPITFETP ESFISLPKWN AKKTGSISFD FRTTEPNGLI LFSHGKPRHQ
560 570 580 590 600
KDAKHPQMIK VDFFAIEMLD GHLYLLLDMG SGTIKIKALQ KKVNDGEWYH
610 620 630 640 650
VDFQRDGRSG TISVNTLRTP YTAPGESQIL DLDDELYLGG LPENKAGLVF
660 670 680 690 700
PTEVWTALLN YGYVGCIRDL FIDGQSKDIR QMAEVQSTAG VKPSCSRETA
710 720 730 740 750
KPCLSNPCKN NGMCRDGWNR YVCDCSGTGY LGRSCEREAT VLSYDGSMFM
760 770 780 790 800
KIQLPVVMHT EAEDVSLRFR SQRAYGILMA TTSRDSADTL RLELDAGRVK
810 820 830 840 850
LTVNLDCIRI NCNSSKGPET LFAGYNLNDN EWHTVRVVRR GKSLKLTVDD
860 870 880 890 900
QQAMTGQMAG DHTRLEFHNI ETGIITERRY LSSVPSNFIG HLQSLTFNGM
910 920 930 940 950
AYIDLCKNGD IDYCELNARF GFRNIIADPV TFKTKSSYVA LATLQAYTSM
960 970 980 990 1000
HLFFQFKTTS LDGLILYNSG DGNDFIVVEL VKGYLHYVFD LGNGANLIKG
1010 1020 1030 1040 1050
SSNKPLNDNQ WHNVMISRDT SNLHTVKIDT KITTQITAGA RNLDLKSDLY
1060 1070 1080 1090 1100
IGGVAKETYK SLPKLVHAKE GFQGCLASVD LNGRLPDLIS DALFCNGQIE
1110 1120 1130 1140 1150
RGCEGPSTTC QEDSCSNQGV CLQQWDGISC DCSMTSFSGP LCNDPGTTYI
1160 1170 1180 1190 1200
FSKGGGQITY KWPPNDRPST RADRLAIGFS TVQKEAVLVR VDSSSGLGDY
1210 1220 1230 1240 1250
LELHIHQGKI GVKFNVGTDD IAIEESNAII NDGKYHVVRF TRSGGNATLQ
1260 1270 1280 1290 1300
VDSWPVIERY PAGNNDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN
1310 1320 1330 1340 1350
SQATIIIGGK EQGQPFQGQL SGLYYNGLKV LNMAAENDAN IAIVGNVRLV
1360 1370 1380 1390 1400
GEVPSSMTTE STATAMQSEM STSIMETTTT LATSTARRGK PPTKEPVSQT
1410 1420 1430 1440 1450
TDDILVASAE CPSDDEDIDP CEPSSGGLAN PTRAGGREPY PGSAEVIRES
1460 1470 1480 1490 1500
SSTTGMVVGI VAAAALCILI LLYAMYKYRN RDEGSYHVDE SRNYISNSAQ
1510 1520 1530
SNGAVVKEKQ PSSAKSANKN KKNKDKEYYV
Length:1,530
Mass (Da):167,939
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A4E4A75C4EC03D1
GO
Isoform 2a (identifier: Q28146-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     278-293: Missing.

Show »
Length:1,514
Mass (Da):166,184
Checksum:iCD1B8650A183C789
GO
Isoform 3a (identifier: Q28146-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.
     278-293: Missing.

Show »
Length:1,513
Mass (Da):166,055
Checksum:i4BF85979B6828A64
GO
Isoform 4a (identifier: Q28146-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1D

The sequence of this isoform differs from the canonical sequence as follows:
     274-293: Missing.

Show »
Length:1,510
Mass (Da):165,783
Checksum:i999348A15A299E5B
GO
Isoform 5a (identifier: Q28146-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.
     274-293: Missing.

Show »
Length:1,509
Mass (Da):165,654
Checksum:iDE92054CBD9D8970
GO
Isoform 6a (identifier: Q28146-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-1F

The sequence of this isoform differs from the canonical sequence as follows:
     264-273: Missing.
     278-293: Missing.

Show »
Length:1,504
Mass (Da):165,130
Checksum:i00CF8E297D4306EC
GO
Isoform 7a (identifier: Q28146-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-1G

The sequence of this isoform differs from the canonical sequence as follows:
     258-293: Missing.

Show »
Length:1,494
Mass (Da):164,028
Checksum:i3ACA6902A43B3F36
GO
Isoform 8a (identifier: Q28146-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     403-409: Missing.

Show »
Length:1,523
Mass (Da):167,157
Checksum:i2A97DE64CF3B1AB8
GO
Isoform 9a (identifier: Q28146-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     395-409: Missing.

Show »
Length:1,515
Mass (Da):166,402
Checksum:i505A40B67ECA57A8
GO
Isoform 10a (identifier: Q28146-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     806-815: DCIRINCNSS → G

Show »
Length:1,521
Mass (Da):166,890
Checksum:iB36B0040832AD591
GO
Isoform 11a (identifier: Q28146-11) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1263-1292: Missing.

Show »
Length:1,500
Mass (Da):164,376
Checksum:iFFF0536B1443D542
GO
Isoform 12a (identifier: Q28146-12) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1426-1428: Missing.

Show »
Length:1,527
Mass (Da):167,711
Checksum:i4E97EBE1D1383A03
GO
Isoform 1b (identifier: Q28142-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:467
Mass (Da):50,084
GO
Isoform 2b (identifier: Q28142-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:464
Mass (Da):49,857
GO
Isoform 3b (identifier: Q28142-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:437
Mass (Da):46,521
GO
Isoform 4b (identifier: Q28142-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B
The sequence of this isoform can be found in the external entry Q28142.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:434
Mass (Da):46,294
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003475258 – 293Missing in isoform 7a. CuratedAdd BLAST36
Alternative sequenceiVSP_003474258Missing in isoform 3a and isoform 5a. Curated1
Alternative sequenceiVSP_003476264 – 273Missing in isoform 6a. Curated10
Alternative sequenceiVSP_003477274 – 293Missing in isoform 4a and isoform 5a. CuratedAdd BLAST20
Alternative sequenceiVSP_003478278 – 293Missing in isoform 2a, isoform 3a and isoform 6a. CuratedAdd BLAST16
Alternative sequenceiVSP_003479395 – 409Missing in isoform 9a. CuratedAdd BLAST15
Alternative sequenceiVSP_003480403 – 409Missing in isoform 8a. Curated7
Alternative sequenceiVSP_003481806 – 815DCIRINCNSS → G in isoform 10a. Curated10
Alternative sequenceiVSP_0034821263 – 1292Missing in isoform 11a. CuratedAdd BLAST30
Alternative sequenceiVSP_0034831426 – 1428Missing in isoform 12a. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L14855 mRNA Translation: AAA74123.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I45944

NCBI Reference Sequences

More...
RefSeqi
NP_776829.1, NM_174404.2 [Q28146-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281950

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14855 mRNA Translation: AAA74123.1
PIRiI45944
RefSeqiNP_776829.1, NM_174404.2 [Q28146-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H0BX-ray2.10A/B/C/D295-491[»]
2R16X-ray1.04A737-925[»]
3ASIX-ray2.30A923-1353[»]
3POYX-ray3.02A296-1349[»]
3QCWX-ray2.65A/B31-1355[»]
3R05X-ray2.95A/B31-1355[»]
6CW1X-ray2.84A/B258-690[»]
SMRiQ28146
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59135N
IntActiQ28146, 1 interactor
STRINGi9913.ENSBTAP00000033006

PTM databases

iPTMnetiQ28146

Proteomic databases

PaxDbiQ28146
PRIDEiQ28146

Genome annotation databases

GeneIDi281950
KEGGibta:281950

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9378

Phylogenomic databases

HOGENOMiHOG000230481
InParanoidiQ28146
KOiK07377
OrthoDBi35129at2759

Miscellaneous databases

EvolutionaryTraceiQ28146

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR001791 Laminin_G
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX1A_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28146
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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