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Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Coagulation factor V

Gene

F5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi139Calcium1
Metal bindingi140Calcium1
Metal bindingi1830Copper1
Metal bindingi1832Copper1
Metal bindingi1872Copper1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Copper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor V
Alternative name(s):
Activated protein C cofactor
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000297429 – 2211Coagulation factor VAdd BLAST2183
ChainiPRO_000000297529 – 741Coagulation factor V heavy chainBy similarityAdd BLAST713
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000002976742 – 1564Activation peptide (connecting region)By similarityAdd BLAST823
ChainiPRO_00000029771565 – 2211Coagulation factor V light chainBy similarityAdd BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 193
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi225N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi239N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi248 ↔ 329
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi499 ↔ 525
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi607 ↔ 688
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei644PhosphothreonineBy similarity1
Modified residuei697SulfotyrosineSequence analysis1
Modified residuei701SulfotyrosineSequence analysis1
Modified residuei730SulfotyrosineSequence analysis1
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi902N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi952N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1044N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1062N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1071N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1078N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1094N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1490N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1513SulfotyrosineSequence analysis1
Modified residuei1529SulfotyrosineSequence analysis1
Modified residuei1537SulfotyrosineSequence analysis1
Modified residuei1541SulfotyrosineSequence analysis1
Glycosylationi1550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1690N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1712 ↔ 1738Curated
Glycosylationi1839N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1894 ↔ 2048
Glycosylationi1997N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2053 ↔ 2208
Glycosylationi2196N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.By similarity
Activated protein C inactivates factor V and factor Va by proteolytic degradation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei334 – 335Cleavage; by activated protein CBy similarity2
Sitei533 – 534Cleavage; by activated protein CBy similarity2
Sitei741 – 742Cleavage; by thrombinBy similarity2
Sitei1034 – 1035Cleavage; by thrombinBy similarity2
Sitei1564 – 1565Cleavage; by thrombin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q28107

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q28107

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q28107

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000023573

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28107

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q28107

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 327F5/8 type A 1Add BLAST298
Domaini30 – 193Plastocyanin-like 1Add BLAST164
Domaini203 – 327Plastocyanin-like 2Add BLAST125
Domaini348 – 686F5/8 type A 2Add BLAST339
Domaini348 – 525Plastocyanin-like 3Add BLAST178
Domaini535 – 686Plastocyanin-like 4Add BLAST152
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1124 – 11371-1Add BLAST14
Repeati1138 – 11511-2Add BLAST14
Repeati1188 – 11962-19
Repeati1197 – 12052-29
Repeati1206 – 12142-39
Repeati1215 – 12232-49
Repeati1224 – 12322-59
Repeati1233 – 12412-69
Repeati1242 – 12502-79
Repeati1251 – 12592-89
Repeati1260 – 12682-99
Repeati1269 – 12772-109
Repeati1278 – 12862-119
Repeati1287 – 12952-129
Repeati1296 – 13042-139
Repeati1305 – 13132-149
Repeati1314 – 13222-159
Repeati1323 – 13312-169
Repeati1332 – 13402-179
Repeati1341 – 13492-189
Repeati1350 – 13582-199
Repeati1359 – 13672-209
Repeati1368 – 13762-219
Repeati1377 – 13852-229
Repeati1386 – 13942-239
Repeati1395 – 14032-249
Repeati1404 – 14122-259
Repeati1413 – 14212-269
Repeati1422 – 14302-279
Repeati1431 – 14392-289
Repeati1440 – 14442-29; truncated5
Repeati1445 – 14532-309
Domaini1569 – 1890F5/8 type A 3Add BLAST322
Domaini1569 – 1738Plastocyanin-like 5Add BLAST170
Domaini1748 – 1890Plastocyanin-like 6Add BLAST143
Domaini1894 – 2048F5/8 type C 1PROSITE-ProRule annotationAdd BLAST155
Domaini2053 – 2208F5/8 type C 2PROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni696 – 1564BAdd BLAST869
Regioni1124 – 11512 X 14 AA tandem repeatsAdd BLAST28
Regioni1188 – 145330 X 9 AA approximate tandem repeats of [AS]-L-S-P-D-[LP]-[GS]-Q-[TE]Add BLAST266

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain B contains 29.5 X 9 AA tandem repeats, and 2 X 14 AA repeats.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28107

KEGG Orthology (KO)

More...
KOi
K03902

Database of Orthologous Groups

More...
OrthoDBi
454773at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009271 Coagulation_factor_V_LSPD
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8-like
IPR008979 Galactose-bd-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07732 Cu-oxidase_3, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF06049 LSPR, 28 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000354 Factors_V_VIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00231 FA58C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLACPGFWV LVVLGSSWAG WGNLGAEAAK LRQFYVAAQS IRWNYRPEST
60 70 80 90 100
HLSSKPFETS FKKIVYREYE AYFQKEKPQS RTSGLLGPTL YAEVGDIMKV
110 120 130 140 150
HFKNKAHKPL SIHAQGIKYS KFSEGASYSD HTLPMEKMDD AVAPGQEYTY
160 170 180 190 200
EWIISEHSGP THDDPPCLTH IYYSYVNLVE DFNSGLIGPL LICKKGTLTE
210 220 230 240 250
DGTQKMFEKQ HVLMFAVFDE SKSWNQTSSL MYTVNGYVNG TMPDITVCAH
260 270 280 290 300
DHISWHLIGM SSGPELFSIH FNGQVLEQNH HKISAITLVS ATSTTANMTV
310 320 330 340 350
SPEGRWTIAS LIPRHFQAGM QAYIDIKNCA KKTRNPKKLT RDQRRHIKRW
360 370 380 390 400
EYFIAAEEVI WDYAPIIPAN MDKKYRSLHL DNFSNRIGKH YKKVVYKQYQ
410 420 430 440 450
DDSFTKRLED PSSEGDGILG PIIRAQVRDT LKIVFKNMAS RSYSIYPHGV
460 470 480 490 500
TFSPYDNEVN SSSTSGSNTM IRAVRPGETY TYKWNILESD EPTENDAQCL
510 520 530 540 550
TRPYYSNVDI TRDLASGLIG LLLICKSRSL DRRGIQRAAD IEQQAVFAVF
560 570 580 590 600
DENKSWYIED NIYKFCENPE KVKRDDPKFY ESNIMSNFTL PAINGYVPES
610 620 630 640 650
IPILGFCFDD TVQWHFCSVG TQNDILTIHF TGHSFIYGKR HEDTLTLFPM
660 670 680 690 700
QGESVTVTMD NVGTWMLTTM NSNPRSKKLR LRFRDAKCIR NDDDDSYEII
710 720 730 740 750
YEPSGSTAMT TKKIHDSSEI EDENDADSDY QDELALILGL RSFRNSSLNQ
760 770 780 790 800
EKDELNLTAL ALEKDSEFIP PSANRSLDSN SSSRSHVSRL IAKNFAESLK
810 820 830 840 850
TLLHLEAPAA GSPLEHAGLD KNSALNPPMA EHSSPYSEDP REDHPLSDVT
860 870 880 890 900
GVSLLPFGTG FKNRKPAKHQ RFQVGRGQAA KHKFSQTRFP AHKTRTRLSQ
910 920 930 940 950
DNSSSSRMGP WEDIPSDLLL LQQKDPYKIL NGEWHLVSEK GSYEIIQDAN
960 970 980 990 1000
ENKTVNKLPN SPQNDSRTWG ENIPFKNSHG KQSGHPTFLV TRRKPLQDRQ
1010 1020 1030 1040 1050
DRRNSRLKEG LPLIRTRRKK KEEKPAYHVP LSPRSFHPLR GEVNASFSDR
1060 1070 1080 1090 1100
RHNHSLLLHA SNETSLSIDL NQTFPSMNLS LAASLPDHDQ TSPNDTTSQT
1110 1120 1130 1140 1150
SSPPDLYPTV SPEEHYQIFP IQDSDPTHST TAPSNRSPDP THSTTAPSNR
1160 1170 1180 1190 1200
SPPTQPSQIP NYDLRNRAIP TDVSQIFPSL ELEVWQTATS LDLSQPSISP
1210 1220 1230 1240 1250
DLGQMALSPD PGQESLSPDL GQTSLSPDLS QESLSPDLGQ TALSPDPSQE
1260 1270 1280 1290 1300
SLSPDLGQTA LSPDPSQESL SPDLGQTALS PDPGQESLSP DLGQTSLSPD
1310 1320 1330 1340 1350
LSQESLSPDL GQTALSPDPS QESLSPDLGQ TALSPDPSQE SLSPDLGQTS
1360 1370 1380 1390 1400
LSPDLGQESL SPDLGQTALS PDPSQESLSP DLGQTSLSPD LGQESLSPDL
1410 1420 1430 1440 1450
GQTALSPDLS QESLSPDLGQ TPLSPDLSLE SLSPDLSQLD LKQTSPPLDL
1460 1470 1480 1490 1500
NQTSHTSESS QSLPLPEFGQ TFPNADIGQM PSPPPDSTLN NTFIPEEFNP
1510 1520 1530 1540 1550
LVVVGLSRDD GDYIEIIPRQ KEESSEEDYG EFEFVAYNDP YQTDLRTDIN
1560 1570 1580 1590 1600
SSRNPDNIAA WYLRSNTGNR KYYYIAAEEI SWDYSKFVQS DDVDYVPEDT
1610 1620 1630 1640 1650
VYKKVVFRKY LDSTFTKLDP QGEYEEHLGI LGPVIRAEVD DVIQVRFKNL
1660 1670 1680 1690 1700
ASRPYSLHAH GLSYEKSSEG KTYEDDSPEW FKEDNAIQPN KTYTYVWHAT
1710 1720 1730 1740 1750
TRSGPENPGS ACRAWAYYSA VNPEKDIHSG LIGPLLICRK GTLDKETNMP
1760 1770 1780 1790 1800
VDMREFVLLF MVFDEKKSWY YDKKPTRSWR RASSEVKNSH EFHAINGMIY
1810 1820 1830 1840 1850
NLPGLRMYEQ EWVRLHLLNL GGSRDIHVVH FHGQTLLENG TQQHQLGVWP
1860 1870 1880 1890 1900
LLPGSFKTLE MKASKPGWWL LDTEVGEIQR AGMQTPFLIV DRECKMPMGL
1910 1920 1930 1940 1950
STGLIADSQI QASEFWGYWE PKLARLNNGG SYNAWIAEKL STEFNPEPWI
1960 1970 1980 1990 2000
QVDMQKEVLL TGIQTQGAKH YLKPYYTTEF CVAYSLDRKN WRIFKGNSTR
2010 2020 2030 2040 2050
NVMYFGGNSD ASTIKENQID PPVVARYIRI SPTGSYNKPA LRLELQGCEV
2060 2070 2080 2090 2100
NGCSTPLGME SGKIENKQIT ASSFKKSWWG NYWEPFLARL NAQGRVNAWQ
2110 2120 2130 2140 2150
AKANNNNQWL QIDLLKIKKI TAIVTQGCKS LSSEMYVKSY TIHYSDQGTD
2160 2170 2180 2190 2200
WKPYREKSSM VDKIFEGNNN VRGHVKNFFN PPIISRFIRI IPKTWNQSIA
2210
LRLELFGCDM Y
Length:2,211
Mass (Da):248,983
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBBF90B738667C45
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti587 – 592NFTLPA → T in variant 2. 6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M81440 mRNA Translation: AAA30512.1
M81441 mRNA Translation: AAA30513.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A42580 KFBO5

NCBI Reference Sequences

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RefSeqi
NP_776304.1, NM_173879.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
280687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:280687

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81440 mRNA Translation: AAA30512.1
M81441 mRNA Translation: AAA30513.1
PIRiA42580 KFBO5
RefSeqiNP_776304.1, NM_173879.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SDDX-ray2.80A29-334[»]
B1565-2211[»]
SMRiQ28107
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023573

PTM databases

iPTMnetiQ28107

Proteomic databases

PRIDEiQ28107

Genome annotation databases

GeneIDi280687
KEGGibta:280687

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2153

Phylogenomic databases

HOGENOMiHOG000082542
InParanoidiQ28107
KOiK03902
OrthoDBi454773at2759

Miscellaneous databases

EvolutionaryTraceiQ28107
PMAP-CutDBiQ28107

Family and domain databases

CDDicd00057 FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR009271 Coagulation_factor_V_LSPD
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8-like
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF07732 Cu-oxidase_3, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF06049 LSPR, 28 hits
PIRSFiPIRSF000354 Factors_V_VIII, 1 hit
SMARTiView protein in SMART
SM00231 FA58C, 2 hits
SUPFAMiSSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA5_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28107
Secondary accession number(s): Q28108
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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