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Protein

Coatomer subunit epsilon

Gene

COPE

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878 COPI-mediated anterograde transport
R-BTA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:COPE
Synonyms:COPE1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:27595 COPE

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938491 – 308Coatomer subunit epsilonAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ28104
PeptideAtlasiQ28104
PRIDEiQ28104

Expressioni

Gene expression databases

BgeeiENSBTAG00000000810 Expressed in 9 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
COPAQ279545EBI-620457,EBI-620400

Protein-protein interaction databases

IntActiQ28104, 1 interactor
STRINGi9913.ENSBTAP00000001071

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ28104
SMRiQ28104
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28104

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 219Poly-Leu4

Sequence similaritiesi

Belongs to the COPE family.Curated

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiQ28104
KOiK17268
OMAiDAFHIYQ
OrthoDBiEOG091G0KHF
TreeFamiTF313390

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits

Sequencei

Sequence statusi: Complete.

Q28104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKPSSPERDV
60 70 80 90 100
ERDVFLYRAY LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASDSRRDAI
110 120 130 140 150
VAELDREMSR SVDVTNTTFL LMAASIYFYD QNPDAALRTL HQGDSLECMA
160 170 180 190 200
MTVQILLKLD RLDLARKELK KMQDQDEDAT LTQLATAWVS LAAGGEKLQD
210 220 230 240 250
AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGVLQ EALDKDSGHP
260 270 280 290 300
ETLINLVVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY RAKENDFDRL

VLQYAPSA
Length:308
Mass (Da):34,481
Last modified:January 23, 2007 - v3
Checksum:i219385CA17A3B7DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94D → H in CAA54287 (PubMed:8132710).Curated1
Sequence conflicti118T → N in AAI09964 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76980 mRNA Translation: CAA54287.1
AB042117 mRNA Translation: BAA94967.1
BT029899 mRNA Translation: ABM06145.1
BC109963 mRNA Translation: AAI09964.1
PIRiI46019
RefSeqiNP_788846.1, NM_176673.1
UniGeneiBt.4141

Genome annotation databases

EnsembliENSBTAT00000001071; ENSBTAP00000001071; ENSBTAG00000000810
GeneIDi338085
KEGGibta:338085

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76980 mRNA Translation: CAA54287.1
AB042117 mRNA Translation: BAA94967.1
BT029899 mRNA Translation: ABM06145.1
BC109963 mRNA Translation: AAI09964.1
PIRiI46019
RefSeqiNP_788846.1, NM_176673.1
UniGeneiBt.4141

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MKRX-ray2.60A17-307[»]
ProteinModelPortaliQ28104
SMRiQ28104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ28104, 1 interactor
STRINGi9913.ENSBTAP00000001071

Proteomic databases

PaxDbiQ28104
PeptideAtlasiQ28104
PRIDEiQ28104

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001071; ENSBTAP00000001071; ENSBTAG00000000810
GeneIDi338085
KEGGibta:338085

Organism-specific databases

CTDi11316
VGNCiVGNC:27595 COPE

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiQ28104
KOiK17268
OMAiDAFHIYQ
OrthoDBiEOG091G0KHF
TreeFamiTF313390

Enzyme and pathway databases

ReactomeiR-BTA-6807878 COPI-mediated anterograde transport
R-BTA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

EvolutionaryTraceiQ28104

Gene expression databases

BgeeiENSBTAG00000000810 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCOPE_BOVIN
AccessioniPrimary (citable) accession number: Q28104
Secondary accession number(s): A1L5B2, Q2TBL7, Q9N286
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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