UniProtKB - Q28071 (CD28_BOVIN)
Protein
T-cell-specific surface glycoprotein CD28
Gene
CD28
Organism
Bos taurus (Bovine)
Status
Functioni
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.By similarity
GO - Biological processi
- immune response Source: InterPro
- immune system process Source: GO_Central
- positive regulation of interleukin-10 production Source: UniProtKB
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of mitotic nuclear division Source: UniProtKB
- positive regulation of T cell proliferation Source: UniProtKB
- T cell activation Source: GO_Central
- T cell costimulation Source: GO_Central
- T cell receptor signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: T-cell-specific surface glycoprotein CD28Alternative name(s): CD_antigen: CD28 |
Gene namesi | Name:CD28 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 151 | ExtracellularSequence analysisAdd BLAST | 133 | |
Transmembranei | 152 – 178 | HelicalSequence analysisAdd BLAST | 27 | |
Topological domaini | 179 – 219 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014651 | 19 – 219 | T-cell-specific surface glycoprotein CD28Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 40 ↔ 111 | By similarity | ||
Disulfide bondi | 66 ↔ 85 | By similarity | ||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 208 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q28071 |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
Interacts with GRB2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009792 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 136 | Ig-like V-typeAdd BLAST | 109 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SAVP, Eukaryota |
InParanoidi | Q28071 |
OrthoDBi | 1222373at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008093, CD28 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit |
Pfami | View protein in Pfam PF15910, V-set_2, 1 hit |
PRINTSi | PR01717, CD28ANTIGEN |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q28071-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLLLALNF FPSIQVAENK ILVKQSPMLV VNDNEVNLSC KYTYNLFSKE
60 70 80 90 100
FRASLYKGAD SAVEVCAVNG NHSHPLQSTN KEFNCTVKVG NETVTFYLQD
110 120 130 140 150
LYVNQTDIYF CKLEVLYPPP YIDNEKSNGT IIHVKEKHLC PSPRSPESSK
160 170 180 190 200
PFWALVVVNG VLVFYSLLVT VALSNCWMKN KRNRMLQSDY MNMTPRRPGP
210
TRRHYQPYAP ARDFAAYRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X93304 mRNA Translation: CAA63707.1 |
RefSeqi | NP_851347.1, NM_181004.1 |
Genome annotation databases
GeneIDi | 281050 |
KEGGi | bta:281050 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X93304 mRNA Translation: CAA63707.1 |
RefSeqi | NP_851347.1, NM_181004.1 |
3D structure databases
SMRi | Q28071 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009792 |
Proteomic databases
PaxDbi | Q28071 |
Genome annotation databases
GeneIDi | 281050 |
KEGGi | bta:281050 |
Organism-specific databases
CTDi | 940 |
Phylogenomic databases
eggNOGi | ENOG502SAVP, Eukaryota |
InParanoidi | Q28071 |
OrthoDBi | 1222373at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008093, CD28 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit |
Pfami | View protein in Pfam PF15910, V-set_2, 1 hit |
PRINTSi | PR01717, CD28ANTIGEN |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD28_BOVIN | |
Accessioni | Q28071Primary (citable) accession number: Q28071 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |