UniProtKB - Q28050 (S10A7_BOVIN)
Protein
Protein S100-A7
Gene
S100A7
Organism
Bos taurus (Bovine)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 18 | ZincBy similarity | 1 | |
Metal bindingi | 25 | ZincBy similarity | 1 | |
Metal bindingi | 87 | ZincBy similarity | 1 | |
Metal bindingi | 91 | ZincBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 63 – 74 | 2; high affinityPROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: GO_Central
- transition metal ion binding Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation R-BTA-6799990, Metal sequestration by antimicrobial proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A7Alternative name(s): Calcium-binding protein in amniotic fluid 2 Short name: CAAF2 Dander minor allergen BDA11 Dermal allergen BDA11 S100 calcium-binding protein A7 Allergen: Bos d 3 |
Gene namesi | Name:S100A7 Synonyms:CAAF2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Minor allergen of bovine dander.
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 162, Bos d 3 3164, Bos d 3.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000143989 | 2 – 101 | Protein S100-A7Add BLAST | 100 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q28050 |
PeptideAtlasi | Q28050 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000008238, Expressed in intercostal muscle and 10 other tissues |
ExpressionAtlasi | Q28050, baseline |
Interactioni
Subunit structurei
Interacts with RANBP9.
By similarityGO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000010838 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 42 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 50 – 85 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502SZJ5, Eukaryota |
GeneTreei | ENSGT00940000163629 |
HOGENOMi | CLU_138624_5_0_1 |
InParanoidi | Q28050 |
OMAi | DIANDYH |
OrthoDBi | 1486203at2759 |
TreeFami | TF341148 |
Family and domain databases
CDDi | cd00213, S-100, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034325, S-100_dom IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub IPR028477, S100A7 |
PANTHERi | PTHR11639:SF67, PTHR11639:SF67, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00303, S100_CABP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q28050-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSQLEQAI TDLINLFHKY SGSDDTIEKE DLLRLMKDNF PNFLGACEKR
60 70 80 90 100
GRDYLSNIFE KQDKNKDRKI DFSEFLSLLA DIATDYHNHS HGAQLCSGGN
Q
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | D → E AA sequence (PubMed:7594639).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39834 mRNA Translation: AAA91101.1 D49550 mRNA Translation: BAA08498.1 BC142114 mRNA Translation: AAI42115.1 |
RefSeqi | NP_777021.1, NM_174596.2 |
Genome annotation databases
Ensembli | ENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238 |
GeneIDi | 282344 |
KEGGi | bta:282344 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39834 mRNA Translation: AAA91101.1 D49550 mRNA Translation: BAA08498.1 BC142114 mRNA Translation: AAI42115.1 |
RefSeqi | NP_777021.1, NM_174596.2 |
3D structure databases
SMRi | Q28050 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000010838 |
Protein family/group databases
Allergomei | 162, Bos d 3 3164, Bos d 3.0101 |
Proteomic databases
PaxDbi | Q28050 |
PeptideAtlasi | Q28050 |
Genome annotation databases
Ensembli | ENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238 |
GeneIDi | 282344 |
KEGGi | bta:282344 |
Organism-specific databases
CTDi | 6278 |
Phylogenomic databases
eggNOGi | ENOG502SZJ5, Eukaryota |
GeneTreei | ENSGT00940000163629 |
HOGENOMi | CLU_138624_5_0_1 |
InParanoidi | Q28050 |
OMAi | DIANDYH |
OrthoDBi | 1486203at2759 |
TreeFami | TF341148 |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation R-BTA-6799990, Metal sequestration by antimicrobial proteins |
Gene expression databases
Bgeei | ENSBTAG00000008238, Expressed in intercostal muscle and 10 other tissues |
ExpressionAtlasi | Q28050, baseline |
Family and domain databases
CDDi | cd00213, S-100, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034325, S-100_dom IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub IPR028477, S100A7 |
PANTHERi | PTHR11639:SF67, PTHR11639:SF67, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00303, S100_CABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S10A7_BOVIN | |
Accessioni | Q28050Primary (citable) accession number: Q28050 Secondary accession number(s): A5PJH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries