UniProtKB - Q28031 (LPAR1_BOVIN)
Lysophosphatidic acid receptor 1
LPAR1
Functioni
Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca2+ levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 39 | Lysophosphatidic acidBy similarity | 1 | |
Binding sitei | 210 | Lysophosphatidic acidBy similarity | 1 |
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- lysophosphatidic acid receptor activity Source: UniProtKB
GO - Biological processi
- activation of phospholipase C activity Source: UniProtKB
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
- neurogenesis Source: GO_Central
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of Rho protein signal transduction Source: UniProtKB
- positive regulation of stress fiber assembly Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophosphatidic acid receptor 1Short name: LPA receptor 1 Short name: LPA-1 Alternative name(s): Lysophosphatidic acid receptor Edg-2 Rec1.31 Publication |
Gene namesi | Name:LPAR1 Synonyms:EDG2, LPA1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Endosome
- Endosome By similarity
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Cell surface By similarity
Note: Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.By similarity
Endosome
- endosome Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 50 | ExtracellularBy similarityAdd BLAST | 50 | |
Transmembranei | 51 – 75 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 76 – 83 | CytoplasmicBy similarity | 8 | |
Transmembranei | 84 – 107 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 108 – 121 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 122 – 144 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 145 – 163 | CytoplasmicBy similarityAdd BLAST | 19 | |
Transmembranei | 164 – 184 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 185 – 204 | ExtracellularBy similarityAdd BLAST | 20 | |
Transmembranei | 205 – 225 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 226 – 255 | CytoplasmicBy similarityAdd BLAST | 30 | |
Transmembranei | 256 – 280 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 281 – 294 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 295 – 315 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 316 – 364 | CytoplasmicBy similarityAdd BLAST | 49 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069416 | 1 – 364 | Lysophosphatidic acid receptor 1Add BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 190 | By similarity | ||
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 188 ↔ 195 | By similarity | ||
Disulfide bondi | 284 ↔ 287 | By similarity | ||
Modified residuei | 341 | PhosphoserineBy similarity | 1 | |
Modified residuei | 351 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q28031 |
Interactioni
Subunit structurei
Interacts with RALA and GRK2 (By similarity).
Interacts with GNAQ and GNA13.
Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000012721 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 129 | Lysophosphatidic acid bindingBy similarity | 6 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q28031 |
OrthoDBi | 989859at2759 |
Family and domain databases
CDDi | cd15344, 7tmA_LPAR1_Edg2, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004065, LPA_rcpt IPR002277, LPA_rcpt_EDG2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01148, EDG2RECEPTOR PR00237, GPCRRHODOPSN PR01527, LPARECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAAAFTSSPV VSQPQFTAMN EQQCFSNESI AFFYNRSGKY LATEWNTVTK
60 70 80 90 100
LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTVSVANLL AIAIERHITV
160 170 180 190 200
FRMQLHARMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENTSGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U48236 mRNA Translation: AAC48695.1 |
RefSeqi | NP_776472.1, NM_174047.2 |
Genome annotation databases
GeneIDi | 281136 |
KEGGi | bta:281136 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U48236 mRNA Translation: AAC48695.1 |
RefSeqi | NP_776472.1, NM_174047.2 |
3D structure databases
AlphaFoldDBi | Q28031 |
SMRi | Q28031 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000012721 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | Q28031 |
Genome annotation databases
GeneIDi | 281136 |
KEGGi | bta:281136 |
Organism-specific databases
CTDi | 1902 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q28031 |
OrthoDBi | 989859at2759 |
Family and domain databases
CDDi | cd15344, 7tmA_LPAR1_Edg2, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004065, LPA_rcpt IPR002277, LPA_rcpt_EDG2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01148, EDG2RECEPTOR PR00237, GPCRRHODOPSN PR01527, LPARECEPTOR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LPAR1_BOVIN | |
Accessioni | Q28031Primary (citable) accession number: Q28031 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families