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Entry version 140 (02 Jun 2021)
Sequence version 2 (16 Jan 2004)
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Protein

Latent-transforming growth factor beta-binding protein 2

Gene

LTBP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an integral structural role in elastic-fiber architectural organization and/or assembly.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding, Heparin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 2
Short name:
LTBP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35By similarityAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000764236 – 1842Latent-transforming growth factor beta-binding protein 2Add BLAST1807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi185 ↔ 195PROSITE-ProRule annotation
Disulfide bondi189 ↔ 201PROSITE-ProRule annotation
Disulfide bondi203 ↔ 212PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi388 ↔ 398PROSITE-ProRule annotation
Disulfide bondi392 ↔ 404PROSITE-ProRule annotation
Disulfide bondi406 ↔ 415PROSITE-ProRule annotation
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei494PhosphoserineBy similarity1
Disulfide bondi542 ↔ 564PROSITE-ProRule annotation
Disulfide bondi551 ↔ 577PROSITE-ProRule annotation
Disulfide bondi565 ↔ 580PROSITE-ProRule annotation
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi614 ↔ 625PROSITE-ProRule annotation
Disulfide bondi620 ↔ 634PROSITE-ProRule annotation
Disulfide bondi636 ↔ 649PROSITE-ProRule annotation
Disulfide bondi662 ↔ 684PROSITE-ProRule annotation
Disulfide bondi671 ↔ 697PROSITE-ProRule annotation
Disulfide bondi685 ↔ 700PROSITE-ProRule annotation
Disulfide bondi686 ↔ 712PROSITE-ProRule annotation
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi840 ↔ 853PROSITE-ProRule annotation
Disulfide bondi848 ↔ 862PROSITE-ProRule annotation
Disulfide bondi864 ↔ 877PROSITE-ProRule annotation
Disulfide bondi883 ↔ 894PROSITE-ProRule annotation
Disulfide bondi888 ↔ 903PROSITE-ProRule annotation
Disulfide bondi905 ↔ 920PROSITE-ProRule annotation
Disulfide bondi926 ↔ 937PROSITE-ProRule annotation
Disulfide bondi932 ↔ 946PROSITE-ProRule annotation
Disulfide bondi948 ↔ 960PROSITE-ProRule annotation
Disulfide bondi966 ↔ 977PROSITE-ProRule annotation
Disulfide bondi972 ↔ 986PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1000PROSITE-ProRule annotation
Disulfide bondi1006 ↔ 1017PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1026PROSITE-ProRule annotation
Disulfide bondi1028 ↔ 1041PROSITE-ProRule annotation
Disulfide bondi1047 ↔ 1058PROSITE-ProRule annotation
Disulfide bondi1053 ↔ 1067PROSITE-ProRule annotation
Disulfide bondi1070 ↔ 1083PROSITE-ProRule annotation
Disulfide bondi1089 ↔ 1100PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1131 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1138 ↔ 1152PROSITE-ProRule annotation
Disulfide bondi1154 ↔ 1166PROSITE-ProRule annotation
Glycosylationi1162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1172 ↔ 1184PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1195 ↔ 1208PROSITE-ProRule annotation
Disulfide bondi1214 ↔ 1225PROSITE-ProRule annotation
Disulfide bondi1220 ↔ 1234PROSITE-ProRule annotation
Disulfide bondi1236 ↔ 1249PROSITE-ProRule annotation
Disulfide bondi1255 ↔ 1268PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1277PROSITE-ProRule annotation
Disulfide bondi1281 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1299 ↔ 1311PROSITE-ProRule annotation
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1305 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1322 ↔ 1335PROSITE-ProRule annotation
Disulfide bondi1341 ↔ 1353PROSITE-ProRule annotation
Disulfide bondi1348 ↔ 1362PROSITE-ProRule annotation
Disulfide bondi1364 ↔ 1378PROSITE-ProRule annotation
Disulfide bondi1405 ↔ 1428PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1440PROSITE-ProRule annotation
Glycosylationi1422N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1429 ↔ 1443PROSITE-ProRule annotation
Disulfide bondi1430 ↔ 1455PROSITE-ProRule annotation
Disulfide bondi1481 ↔ 1494PROSITE-ProRule annotation
Disulfide bondi1489 ↔ 1503PROSITE-ProRule annotation
Disulfide bondi1505 ↔ 1518PROSITE-ProRule annotation
Disulfide bondi1524 ↔ 1534PROSITE-ProRule annotation
Disulfide bondi1529 ↔ 1543PROSITE-ProRule annotation
Disulfide bondi1545 ↔ 1558PROSITE-ProRule annotation
Glycosylationi1560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1578 ↔ 1601PROSITE-ProRule annotation
Disulfide bondi1587 ↔ 1613PROSITE-ProRule annotation
Disulfide bondi1602 ↔ 1616PROSITE-ProRule annotation
Disulfide bondi1603 ↔ 1628PROSITE-ProRule annotation
Disulfide bondi1758 ↔ 1769PROSITE-ProRule annotation
Disulfide bondi1764 ↔ 1778PROSITE-ProRule annotation
Disulfide bondi1780 ↔ 1793PROSITE-ProRule annotation
Disulfide bondi1799 ↔ 1814PROSITE-ProRule annotation
Disulfide bondi1809 ↔ 1823PROSITE-ProRule annotation
Disulfide bondi1825 ↔ 1838PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-Glycosylated.By similarity
Contains hydroxylated asparagine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q28019

PRoteomics IDEntifications database

More...
PRIDEi
Q28019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex.

Interacts with SDC4.

Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000029274

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q28019

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 213EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini384 – 416EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini540 – 592TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini610 – 650EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini660 – 712TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini836 – 878EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Domaini879 – 921EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini922 – 961EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini962 – 1001EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1002 – 1042EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1043 – 1084EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1085 – 1126EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1127 – 1167EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1168 – 1209EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1210 – 1250EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1251 – 1294EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini1295 – 1336EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1337 – 1379EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1403 – 1455TB 3PROSITE-ProRule annotationAdd BLAST53
Domaini1477 – 1519EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1520 – 1559EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1576 – 1628TB 4PROSITE-ProRule annotationAdd BLAST53
Domaini1754 – 1794EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1795 – 1839EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 58DisorderedSequence analysisAdd BLAST21
Regioni74 – 153DisorderedSequence analysisAdd BLAST80
Regioni93 – 114Heparin-bindingBy similarityAdd BLAST22
Regioni219 – 283DisorderedSequence analysisAdd BLAST65
Regioni226 – 243Heparin-bindingBy similarityAdd BLAST18
Regioni295 – 318DisorderedSequence analysisAdd BLAST24
Regioni332 – 342Heparin-bindingBy similarityAdd BLAST11
Regioni417 – 443DisorderedSequence analysisAdd BLAST27
Regioni481 – 531DisorderedSequence analysisAdd BLAST51
Regioni731 – 760DisorderedSequence analysisAdd BLAST30
Regioni1631 – 1842C-terminal domainBy similarityAdd BLAST212

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi363 – 365Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi113 – 133Polar residuesSequence analysisAdd BLAST21
Compositional biasi264 – 283Polar residuesSequence analysisAdd BLAST20
Compositional biasi422 – 436Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi481 – 495Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi731 – 751Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q28019

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF07645, EGF_CA, 16 hits
PF00683, TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 20 hits
SM00179, EGF_CA, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 5 hits
SSF57581, SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 13 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 16 hits
PS51364, TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q28019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPPTTARCP GRVLQNPWRS FWPLTLALFV GMGQAQRDPV GRYEPAGRDA
60 70 80 90 100
SRLRRPGGSP VVATAKVYSL FREQDAPVRG SPPAELVQPS WGSPRRSTEA
110 120 130 140 150
EARRPPRAQQ PRRVQPPAQT WRSRPSGQQQ SAPRARAAPA LPRLETVQRP
160 170 180 190 200
RAARGRLTGR NVCGGQCCPG WTTANSTNHC IKPVCQPPCQ NRGSCSRPQL
210 220 230 240 250
CVCRSGFRGA RCEEVIPEEE FDPQNSRPAP RRSAEGPPSL RRSSVAREST
260 270 280 290 300
TARVRPPAPQ LQRARTLSGL SQTRSSQQHV GLSQTTRLYP APAASGQLTS
310 320 330 340 350
NALPMGPGPE RRDGAPQAAY LDRPSSSWGL NLTEKIKKIK IVFTPTICKQ
360 370 380 390 400
TCARGRCANS CERGDTTTLY SQSGHGHDPK SGFRIYFCQI PCLNGGRCIG
410 420 430 440 450
RDECWCPANS TGKFCHLPAP RLDQEPPERG PRHRAPLEGP LKQSTFTLPL
460 470 480 490 500
SNQLASVNPS LVNVHIRHPP EASVQIHQVA RVRGEAEEAP EENSVETRPS
510 520 530 540 550
PRLPAGPGPG RWDSNRIPAR SGEAPRLPPP VVPRTPALLG RCYLSTLNGQ
560 570 580 590 600
CANPLPELTA HEDCCGSVGA FWGVTSCAPC PPRPASPVIE NGQLECPQGY
610 620 630 640 650
KRLNLTHCED VNECLTLGLC EDSECVNTRG SYLCTCRPGL LLDPSRSRCV
660 670 680 690 700
SDKAVSMQQG LCYRLLGPGT CALPLAQRIT KQICCCSRVG KAWGSLCEKC
710 720 730 740 750
PLPGTEAFRE ICPAGHGYTY SSSDIRLSMR KAEEEELARP SRDRGPKRNG
760 770 780 790 800
TLPRPAERQP LRAATGTWVE AETIPDKGDS QASQVTTSVT QLSTWVPGGA
810 820 830 840 850
LGTPTPSVPE QGIPEAREEA QVTAPTNVLV TPAPSGIDRC AAGATNICGP
860 870 880 890 900
GTCVNLPDGY RCICSPGYRL HPSQAYCTDD NECLRDPCKG RGRCVNRVGS
910 920 930 940 950
YSCFCYPGYK LATSGATQEC QDIDECEQPG VCSRGRCTNT EGSYHCECDQ
960 970 980 990 1000
GYIMVRKGHC QDINECRHPG TCPDGKCVNS PGSYTCLPCE EGYRGQGGSC
1010 1020 1030 1040 1050
VDVNECLTPG VCTHGTCINL EGSFRCSCEQ GYEVTPDEKG CKDVDECAIR
1060 1070 1080 1090 1100
ASCPTGLCLN TEGSFTCSAC ESGYWVNEDG TACEDLDECA FPGVCPSGVC
1110 1120 1130 1140 1150
TNTAGSFSCR DCEAGYQPSA LGHTCEDVDE CEDPQSSCLG GECKNTAGSY
1160 1170 1180 1190 1200
QCLCPPGFQL ANGTVCEDVD ECVGEEYCAP RGECLNSHGS FFCLCADGFV
1210 1220 1230 1240 1250
SADGGTSCQD VDECAVTDRC VGGQCVNTDG SFNCVCETGF QPSPESGECV
1260 1270 1280 1290 1300
DIDECEDLGE PICGAWRCEN SPGSYRCVLG CQPGFHMAPT GDCIDIDECA
1310 1320 1330 1340 1350
NDTVCGSHGF CDNTDGAFRC LCDQGFETSP SGWDCVDVNE CELMLAVCGA
1360 1370 1380 1390 1400
ALCENVEGSF LCLCASDLEE YDAQEGRCRP RGAGGPSVPE ARPGAHPPGP
1410 1420 1430 1440 1450
VRMECYSGQK DQTPCSSLLG RNTTQAECCC TQGTGWGDAC DLCPDEDSVE
1460 1470 1480 1490 1500
FSEICPSGKG YIPVEGAWMF GQTTYTDADE CVMFGPGLCR NGRCLNTVPG
1510 1520 1530 1540 1550
YICLCNPGYH YNAASRKCED HDECQDMACE NGECVNTEGS FHCFCSPPLT
1560 1570 1580 1590 1600
LDLSQQRCVN STSGVEDLPD HDIHMDICWK RVTNYVCSHP LHGRRTTYTE
1610 1620 1630 1640 1650
CCCQDGEAWS QQCALCPPRS SEVYAQLCNV ARIEAEREAG IHFRPGYEYS
1660 1670 1680 1690 1700
PGPDDLHYSL YGPDGVPFYN YLGPEDAIPE PLFPSTAGRP GDRIPLPEPP
1710 1720 1730 1740 1750
LQPSELQPHY VASHPGLCCC KNGEEVGSEA VSLPSSPSAH HCQQEHQAGF
1760 1770 1780 1790 1800
EGLQAEECGI LNGCENGRCV RVREGYTCDC FEGFQLDTAH MACVDVNECD
1810 1820 1830 1840
DLNGPAALCV HGHCDNTEGS YRCHCLPGYV AEAGPPHCTA KE
Length:1,842
Mass (Da):198,410
Last modified:January 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C06161EA29AB6AA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA91455 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U35363 mRNA Translation: AAA91455.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_776810.1, NM_174385.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
281905

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bta:281905

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35363 mRNA Translation: AAA91455.1 Different initiation.
RefSeqiNP_776810.1, NM_174385.2

3D structure databases

SMRiQ28019
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029274

Proteomic databases

PaxDbiQ28019
PRIDEiQ28019

Genome annotation databases

GeneIDi281905
KEGGibta:281905

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4053

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
InParanoidiQ28019
OrthoDBi1174178at2759

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF07645, EGF_CA, 16 hits
PF00683, TB, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 20 hits
SM00179, EGF_CA, 18 hits
SUPFAMiSSF57184, SSF57184, 5 hits
SSF57581, SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 13 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 16 hits
PS51364, TB, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q28019
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 2, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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