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Entry version 47 (10 Feb 2021)
Sequence version 1 (04 Apr 2006)
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Protein

Protein Shroom3

Gene

shroom3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:14680628). Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (PubMed:17329357).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processCell shape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom3
Alternative name(s):
Shroom-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shroom3
Synonyms:shrm
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-490228, shroom3.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860681 – 1788Protein Shroom3Add BLAST1788

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q27IV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells of the cement gland.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expresseion initiates in the anterior neural plate and extends posteriorly as neurulation proceeds. At the end of neurulation, expressed in the otic and nasal placodes.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin.

Interacts with ROCK1.

By similarity

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini708 – 811ASD1PROSITE-ProRule annotationAdd BLAST104
Domaini1467 – 1756ASD2PROSITE-ProRule annotationAdd BLAST290

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1653 – 1708Sequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.By similarity
The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR030494, Shrm3
IPR027685, Shroom_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q27IV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQVSQGTIG SPWHQAYHSS SSTSDLSGYN HEFLRRSPDQ YSSRGSMESL
60 70 80 90 100
DQASAAYHHH LPPAKSTNCI DQLVHLHNKR DSAYSSFSTN ASIPEYRSSP
110 120 130 140 150
FSKERSYSME SMHSRNSSGQ EGIKHADIKY IKTVYDVQRG ISEEYEVNSS
160 170 180 190 200
SVKNRNYSRQ PAYNRHSIGP HGRLEQSRFF SESGGFERAA PMPPTRSDSY
210 220 230 240 250
ALTRHHERPN SWSSLDQNRN FRTPKAAGLH STNTSSNAAQ QPKHVHGDGH
260 270 280 290 300
LHPVLERSPE SSPLIKPKQV YSETPQPGQP MLPTGIYPVP APEPHFAHAP
310 320 330 340 350
QPPKNNNGRL YPALAKEGSY GAKSSEKVLP FSEPNKNEKD TQNLRSKSVG
360 370 380 390 400
QYPMNHSVKE REKKQEGPTG FAHYKLHFTA GPDISTSSLT NDRNDQQPLR
410 420 430 440 450
LDNIDINEQQ KNGTKVAEEF SVYAHPAFQN EWSDSKTKQD IASSDIIGLH
460 470 480 490 500
RNSLSSDAHG EHEYHNHFNI ASSSHNKMDE RSNRQADHRK KLESLSFTVH
510 520 530 540 550
ADEADGPSSN PLKPDESPSP SQKKSYDFTR RRLSSSSSQS SKTDGNKLSS
560 570 580 590 600
VFDKVCKIEQ REHENHRSQF LCGNINQSGL STRGQNNKGS FTMVEEIRNK
610 620 630 640 650
FISQDQTPNP NEWRRLSSSH SNEKVTGMHQ LTRQGIVYGL QTGDAQKQMP
660 670 680 690 700
EKQAEKMHSY NQEQNILQAV PDDDNRSFNS QTMPNKEDDW QCAAQDTLGF
710 720 730 740 750
NRAYRNSVKD AQCKVLEATS YRRKDLEISP PHYKKPEKNV RPASAPFRKK
760 770 780 790 800
SSSLSPHAPK ERHSVTPTDN CASIQESQGV FFPSRIGAKR RITAEQKKRS
810 820 830 840 850
YSEPEKMNEV GASESESAPL TVSKMEPVAS FSENSVADRR RIFEREGKAC
860 870 880 890 900
STINLSKPQL KQLQQNALAD YIERKTGRRP SSQETRLLKE RSQSTYFSGS
910 920 930 940 950
IMDNQSMTST SSMNSLNEHN LSYRHREPLS KTGRVSSTLP PGLTGFFDLS
960 970 980 990 1000
SFENNPEYPE NRSRSSSFAH QLRSERLLDH RSKVEFGKGR ETNKPKEVSL
1010 1020 1030 1040 1050
QSDDDVIITS SRRHGKSASA EDLLDRLPQP PALHVRSRSS PASDMKSREY
1060 1070 1080 1090 1100
MSRQEVGNKT SYASASNKEI RSIKSNHFEQ MSFTPSFKNH IDTGEDPVPE
1110 1120 1130 1140 1150
NSSTIQRSAQ LENQRNTKTQ SISGIYSPHP ETKQEPLALP IHSVPAKVTQ
1160 1170 1180 1190 1200
TSLAHATFDY ITAEEYLYSG KRGKESASPT DNKEISDQEW CLPENSSSED
1210 1220 1230 1240 1250
LNDPERFAKY TSAQRPQSFE TKSGNSINET VQQNKSSGPT AGPKFSTSWK
1260 1270 1280 1290 1300
SNGMWSSGSS EAETTFNHGK ISLHISESCL QPQSPMTGQE DEGDDEVFVK
1310 1320 1330 1340 1350
EQDTESFSGT FVPPSPPPFP PPSLEDALLK QRIEKFPLVP NTLDEIWENT
1360 1370 1380 1390 1400
EEASTQVKVK SNERYLQCAS EYTASTESSG SYLLNSGITK RDTDGPLLRL
1410 1420 1430 1440 1450
SSIVPAPEPL ASPVDPTKPI EEQETQPHGA DTSILQSSEG NFNPSDSQST
1460 1470 1480 1490 1500
LPHVRSELMS SEDAKSQELA KEIVTKDKSL ANILDPDSRM KTTMDLMEGL
1510 1520 1530 1540 1550
FTKSSSALKE KNQKRKAKKQ IDNIIAPESE XKEEKRETLD NASNYSAYYS
1560 1570 1580 1590 1600
TSAPKAELLR KMKTIHSQIG GKEEQFDVNE KKAELISSLT CKLEVLKDAK
1610 1620 1630 1640 1650
ESLIDDIKLN NSLGEEVETQ IETLCKPNEF DKYKMFIGDL DKVVNLLLSL
1660 1670 1680 1690 1700
SGRLARVENA LSSLGEDASA EERKTWNEKK KQLCGQHEDA RELKENLDRR
1710 1720 1730 1740 1750
EKLVMDFLGN YLTGEEFAHY QHFVKMKSAL LIEQRELDDK IKLGQEQLRC
1760 1770 1780
LTESLPSDYL ISMKVSLPEE RRSSLGNKSL PPPLTSSL
Length:1,788
Mass (Da):200,726
Last modified:April 4, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9660CB8BEE090784
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ398586 mRNA Translation: ABD59319.1

NCBI Reference Sequences

More...
RefSeqi
NP_001089158.1, NM_001095689.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
734194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:734194

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ398586 mRNA Translation: ABD59319.1
RefSeqiNP_001089158.1, NM_001095689.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PRIDEiQ27IV2

Genome annotation databases

GeneIDi734194
KEGGixla:734194

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
734194
XenbaseiXB-GENE-490228, shroom3.L

Family and domain databases

InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR030494, Shrm3
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM3_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27IV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 4, 2006
Last modified: February 10, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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