UniProtKB - Q27966 (MYO1C_BOVIN)
Unconventional myosin-Ic
MYO1C
Functioni
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).
By similarityIsoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).
By similarityCaution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 88 | ATPBy similarity | 1 | |
Binding sitei | 96 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 139 – 148 | ATPBy similarity | 10 | |
Nucleotide bindingi | 192 – 196 | ATPBy similarity | 5 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- mRNA transport Source: UniProtKB-KW
- protein transport Source: UniProtKB-KW
- vesicle transport along actin filament Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-IcAlternative name(s): Myosin I beta Short name: MMI-beta Short name: MMIb |
Gene namesi | Name:MYO1C |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000001332 |
VGNCi | VGNC:31818, MYO1C |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- stereocilium membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- ruffle By similarity
- Cytoplasmic vesicle By similarity
Note: Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity).By similarity
Nucleus
- nucleolus By similarity
- nucleoplasm By similarity
- nuclear pore complex By similarity
Note: In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity).By similarity
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- myosin complex Source: UniProtKB-KW
Nucleus
- nuclear pore Source: UniProtKB-SubCell
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
- stereocilium membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: UniProtKB-KW
- microvillus Source: GO_Central
- ruffle Source: UniProtKB-SubCell
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000226048 | 1 – 1063 | Unconventional myosin-IcAdd BLAST | 1063 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 383 | N6-methyllysineBy similarity | 1 | ||
Modified residuei | 408 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 486 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 536 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 864 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1041 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: Q27966-2) | |||||
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q27966 |
PeptideAtlasi | Q27966 |
PRIDEi | Q27966 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSBTAG00000001332, Expressed in trachea and 95 other tissues |
ExpressionAtlasi | Q27966, baseline and differential |
Interactioni
Subunit structurei
Interacts with RPS6 and actin.
Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent.
Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM.
Interacts with POLR1A and POLR2A.
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
Interacts with YWHAB; this precludes interaction with CALM. Likewise, interaction with CALM precludes interaction with YWHAB (By similarity).
Interacts (via its IQ motifs) with CALM.
Interacts with LLPH (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- actin filament binding Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000029554 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 731 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 685 | |
Domaini | 734 – 757 | IQ 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Domaini | 758 – 786 | IQ 2PROSITE-ProRule annotationAdd BLAST | 29 | |
Domaini | 885 – 1059 | TH1PROSITE-ProRule annotationAdd BLAST | 175 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 608 – 630 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0164, Eukaryota |
GeneTreei | ENSGT00940000157915 |
HOGENOMi | CLU_000192_7_7_1 |
InParanoidi | Q27966 |
OMAi | ENRDQCI |
OrthoDBi | 122881at2759 |
TreeFami | TF312960 |
Family and domain databases
CDDi | cd01378, MYSc_Myo1, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 2 hits SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD
60 70 80 90 100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH
110 120 130 140 150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT
160 170 180 190 200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK
210 220 230 240 250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF YQLLEGGEEE
260 270 280 290 300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE
310 320 330 340 350
VEDLLSIVAS VLHLGNTHFA ADEESNAQVT TENQLKYLTR LLGVEGSTLR
360 370 380 390 400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVAKINRS
410 420 430 440 450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI
460 470 480 490 500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR
510 520 530 540 550
PGEATDLTFL EKLEDTIKQH PHFLTHKLAD QRTRKSLDRG EFRLLHYAGE
560 570 580 590 600
VTYNVTGFLD KNNDLLFRNL KETMCSSENP ILGQCFDRSE LSDKKRPETV
610 620 630 640 650
ATQFKMSLLE LVEILKSKEP AYVRCIKPND SKQPGRFDEV LIRHQVKYLG
660 670 680 690 700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPTWTGRP QDGVTVLVRH
710 720 730 740 750
LGYKPEEYKM GRTKIFIRFP KTLFATEDAL EIRRQSLATK IQATWRGFHC
760 770 780 790 800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IQGFILRHAP
810 820 830 840 850
RCPENAFFVD HVRTSFLLNL RRQLPRNILD TSWPTPPPAL REASELLREL
860 870 880 890 900
CRKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR
910 920 930 940 950
LGADEINPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV
960 970 980 990 1000
EDAKVKQRIE YTNLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI
1010 1020 1030 1040 1050
ETLTKTALSA DRVNNININQ GSITFAGGPG RDGIIDFTPG SELLITKAKN
1060
GHLAVVAPRL NSR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A452DJY5 | A0A452DJY5_BOVIN | Unconventional myosin-Ic | MYO1C | 1,098 | Annotation score: | ||
A0A3Q1M3N4 | A0A3Q1M3N4_BOVIN | Unconventional myosin-Ic | MYO1C | 1,055 | Annotation score: | ||
A0A3Q1MHV1 | A0A3Q1MHV1_BOVIN | Unconventional myosin-Ic | MYO1C | 1,069 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | A → C in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 132 | R → G in AAA17565 (PubMed:8313976).Curated | 1 | |
Sequence conflicti | 355 | H → N in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 398 | N → K in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 421 | D → G in AAA17565 (PubMed:8313976).Curated | 1 | |
Sequence conflicti | 579 | N → I in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 585 | C → F in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 593 | D → S in AAA17565 (PubMed:8313976).Curated | 1 | |
Sequence conflicti | 690 | P → R in AAA17565 (PubMed:8313976).Curated | 1 | |
Sequence conflicti | 747 | G → A in CAA80476 (PubMed:8022785).Curated | 1 | |
Sequence conflicti | 757 | V → L in CAA80476 (PubMed:8022785).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036860 | 1 – 35 | Missing in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_036859 | 1 – 25 | MALQV…RPCKL → MRYRAS in isoform 3. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03420 mRNA Translation: AAA17565.1 BC140534 mRNA Translation: AAI40535.1 Different initiation. EG705719 mRNA No translation available. Z22852 mRNA Translation: CAA80476.1 |
PIRi | S41749 |
RefSeqi | NP_776821.3, NM_174396.3 [Q27966-1] XP_005220121.1, XM_005220064.1 [Q27966-3] XP_005220122.1, XM_005220065.2 [Q27966-2] |
Genome annotation databases
Ensembli | ENSBTAT00000029555; ENSBTAP00000029554; ENSBTAG00000001332 [Q27966-1] ENSBTAT00000084966; ENSBTAP00000067851; ENSBTAG00000001332 [Q27966-3] |
GeneIDi | 281937 |
KEGGi | bta:281937 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03420 mRNA Translation: AAA17565.1 BC140534 mRNA Translation: AAI40535.1 Different initiation. EG705719 mRNA No translation available. Z22852 mRNA Translation: CAA80476.1 |
PIRi | S41749 |
RefSeqi | NP_776821.3, NM_174396.3 [Q27966-1] XP_005220121.1, XM_005220064.1 [Q27966-3] XP_005220122.1, XM_005220065.2 [Q27966-2] |
3D structure databases
AlphaFoldDBi | Q27966 |
SMRi | Q27966 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000029554 |
Proteomic databases
PaxDbi | Q27966 |
PeptideAtlasi | Q27966 |
PRIDEi | Q27966 |
Genome annotation databases
Ensembli | ENSBTAT00000029555; ENSBTAP00000029554; ENSBTAG00000001332 [Q27966-1] ENSBTAT00000084966; ENSBTAP00000067851; ENSBTAG00000001332 [Q27966-3] |
GeneIDi | 281937 |
KEGGi | bta:281937 |
Organism-specific databases
CTDi | 4641 |
VEuPathDBi | HostDB:ENSBTAG00000001332 |
VGNCi | VGNC:31818, MYO1C |
Phylogenomic databases
eggNOGi | KOG0164, Eukaryota |
GeneTreei | ENSGT00940000157915 |
HOGENOMi | CLU_000192_7_7_1 |
InParanoidi | Q27966 |
OMAi | ENRDQCI |
OrthoDBi | 122881at2759 |
TreeFami | TF312960 |
Gene expression databases
Bgeei | ENSBTAG00000001332, Expressed in trachea and 95 other tissues |
ExpressionAtlasi | Q27966, baseline and differential |
Family and domain databases
CDDi | cd01378, MYSc_Myo1, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 2 hits SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO1C_BOVIN | |
Accessioni | Q27966Primary (citable) accession number: Q27966 Secondary accession number(s): A5D7F3, Q28138 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | April 14, 2009 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families