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Protein

TBP-related factor

Gene

Trf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcription factor. Binds to the TATA box promoter element which lies close to the position of transcription initiation.
May be essential for embryonic development.

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • RNA polymerase III type 2 promoter sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase
  • TFIIA-class transcription factor binding Source: FlyBase
  • TFIIB-class transcription factor binding Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TBP-related factor
Gene namesi
Name:Trf
ORF Names:CG7562
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010287 Trf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539961 – 224TBP-related factorAdd BLAST224

Proteomic databases

PaxDbiQ27896
PRIDEiQ27896

Expressioni

Tissue specificityi

Primary spermatocytes in the adult testis and in a subset of cells in the dorsal medial region of the embryonic CNS.1 Publication

Gene expression databases

BgeeiFBgn0010287
GenevisibleiQ27896 DM

Interactioni

GO - Molecular functioni

  • TFIIA-class transcription factor binding Source: FlyBase
  • TFIIB-class transcription factor binding Source: FlyBase
  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi60234, 5 interactors
STRINGi7227.FBpp0079164

Structurei

3D structure databases

ProteinModelPortaliQ27896
SMRiQ27896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 1271CuratedAdd BLAST77
Repeati141 – 2182CuratedAdd BLAST78

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
InParanoidiQ27896
KOiK03120
OMAiMQFHFKV
OrthoDBiEOG091G0ENY
PhylomeDBiQ27896

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 3 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

Q27896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFHFKVADA ERDRDNVAAT SNAAANPHAA LQPQQPVALV EPKDAQHEIR
60 70 80 90 100
LQNIVATFSV NCELDLKAIN SRTRNSEYSP KRFRGVIMRM HSPRCTALIF
110 120 130 140 150
RTGKVICTGA RNEIEADIGS RKFARILQKL GFPVKFMEYK LQNIVATVDL
160 170 180 190 200
RFPIRLENLN HVHGQFSSYE PEMFPGLIYR MVKPRIVLLI FVNGKVVFTG
210 220
AKSRKDIMDC LEAISPILLS FRKT
Length:224
Mass (Da):25,456
Last modified:November 1, 1996 - v1
Checksum:iCA619BE4BA726460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70837 mRNA Translation: CAA50185.1
X70838 Genomic DNA Translation: CAA50186.1
AE014134 Genomic DNA Translation: AAF52600.1
AY128483 mRNA Translation: AAM75076.1
PIRiS37740
RefSeqiNP_476939.1, NM_057591.4
UniGeneiDm.3090

Genome annotation databases

EnsemblMetazoaiFBtr0079542; FBpp0079164; FBgn0010287
GeneIDi34102
KEGGidme:Dmel_CG7562

Similar proteinsi

Entry informationi

Entry nameiTRF_DROME
AccessioniPrimary (citable) accession number: Q27896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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