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Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

PpV

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in controlling cellularization or in regulating transcription of the genes involved in this process.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi111Manganese 2By similarity1
Active sitei112Proton donorBy similarity1
Metal bindingi161Manganese 2By similarity1
Metal bindingi235Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • negative regulation of JNK cascade Source: FlyBase
  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

SignaLinkiQ27884

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
Short name:
PP6C
Alternative name(s):
Phosphatase V
Short name:
PP-V
Gene namesi
Name:PpV
Synonyms:PPPV6A
ORF Names:CG12217
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003139 PpV

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588801 – 303Serine/threonine-protein phosphatase 6 catalytic subunitAdd BLAST303

Proteomic databases

PaxDbiQ27884
PRIDEiQ27884

Expressioni

Developmental stagei

Expressed at highest levels in 2-4 hours embryos.1 Publication

Gene expression databases

BgeeiFBgn0003139
ExpressionAtlasiQ27884 baseline and differential
GenevisibleiQ27884 DM

Interactioni

Protein-protein interaction databases

BioGridi58069, 3 interactors
DIPiDIP-20494N
IntActiQ27884, 3 interactors
STRINGi7227.FBpp0070883

Structurei

3D structure databases

ProteinModelPortaliQ27884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00550000074961
InParanoidiQ27884
KOiK15498
OMAiKYCCRVF
OrthoDBiEOG091G0B6S
PhylomeDBiQ27884

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q27884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVDKWIED VKKCKYLPEN ELKKLCEMVC DILLEETNIL PVSTPVTVCG
60 70 80 90 100
DIHGQFYDLE QLFRTGGQVP HTNYIFMGDF VDRGYYSLET FTRLLTLKAR
110 120 130 140 150
YPSRITLLRG NHETRQITKV YGFFDECFSK YGNANGWKYC CKVFDLLTIA
160 170 180 190 200
AIIDEEVLCV HGGLSPEIIT LDQIRTIDRN GEIPYKGAFC DLVWSDPEDM
210 220 230 240 250
EYWGQSPRGA GWLFGHNVTK DFMAINNLNL ICRAHQLVNE GIKYMFDGKL
260 270 280 290 300
VTVWSAPNYC YRCGNVAAIL SFETAEKRQT KIFLAVPDAE RVIPKQNTTP

YFL
Length:303
Mass (Da):34,759
Last modified:November 1, 1997 - v1
Checksum:i5269F971416E55EC
GO

Sequence cautioni

The sequence AAM51039 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75980 mRNA Translation: CAA53588.1
AE014298 Genomic DNA Translation: AAF46163.1
BT021230 mRNA Translation: AAX33378.1
AY119179 mRNA Translation: AAM51039.1 Different initiation.
PIRiS39611
RefSeqiNP_001259272.1, NM_001272343.1
NP_001259273.1, NM_001272344.1
NP_001259274.1, NM_001272345.1
NP_511061.1, NM_078506.3
UniGeneiDm.2624

Genome annotation databases

EnsemblMetazoaiFBtr0070921; FBpp0070883; FBgn0003139
FBtr0331430; FBpp0303847; FBgn0003139
FBtr0331431; FBpp0303848; FBgn0003139
FBtr0331432; FBpp0303849; FBgn0003139
GeneIDi31582
KEGGidme:Dmel_CG12217

Similar proteinsi

Entry informationi

Entry nameiPPP6_DROME
AccessioniPrimary (citable) accession number: Q27884
Secondary accession number(s): Q5BIJ4, Q8MRZ7, Q9W3Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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