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Protein

Hypoxanthine phosphoribosyltransferase

Gene

HGPRTase

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (C4B63_102g43), Hypoxanthine phosphoribosyltransferase (C3747_7g328), Hypoxanthine phosphoribosyltransferase (HGPRTase)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

SABIO-RKiQ27796
UniPathwayi
UPA00591;UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:HGPRTaseImported
ORF Names:C3747_99g146Imported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
Proteomesi
  • UP000246078 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Chemistry databases

DrugBankiDB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01942 Formic Acid
DB04198 Formycin B
DB04566 Inosinic Acid

Structurei

3D structure databases

ProteinModelPortaliQ27796
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ27796

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 172PribosyltranInterPro annotationAdd BLAST161

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3367 Eukaryota
COG0634 LUCA

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR005904 Hxn_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01203 HGPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q27796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREYEFAEK ILFTEEEIRT RIMEVAKRIA DDYKGKGLRP YVNPLVLISV
60 70 80 90 100
LKGSFMFTAD LCRALSDFNV PVRMEFICVS SYGEGVTSSG QVRMLLDTRH
110 120 130 140 150
SIEGHHVLIV EDIVDTALTL NYLYHMYFTR RPASLKTVVL LDKREGRRVP
160 170 180 190 200
FSADYVVANI PNAFVIGYGL DYDDTYRELR DIVVLRPEVY AEREAARQKK
210 220
QRAIGSADTD RDAKREFHSK Y
Length:221
Mass (Da):25,529
Last modified:November 1, 1996 - v1
Checksum:iB12CCE38FF149800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07486 Genomic DNA Translation: AAB46391.1
PRFC01000099 Genomic DNA Translation: PWV07656.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07486 Genomic DNA Translation: AAB46391.1
PRFC01000099 Genomic DNA Translation: PWV07656.1

3D structure databases

ProteinModelPortaliQ27796
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01942 Formic Acid
DB04198 Formycin B
DB04566 Inosinic Acid

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3367 Eukaryota
COG0634 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00591;UER00648

SABIO-RKiQ27796

Miscellaneous databases

EvolutionaryTraceiQ27796

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR005904 Hxn_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01203 HGPRTase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ27796_TRYCR
AccessioniPrimary (citable) accession number: Q27796
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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