Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA (cytosine-5)-methyltransferase PliMCI

Gene

DNMT

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Methylates CpG residues.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1183S-adenosyl-L-methionineBy similarity1
Active sitei1218PROSITE-ProRule annotation1
Binding sitei1569S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei1571S-adenosyl-L-methionine; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri626 – 672CXXC-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi2961 M.PliMCDnmt1

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase PliMCI (EC:2.1.1.37)
Alternative name(s):
DNA methyltransferase PliMCI
Short name:
DNA MTase PliMCI
Short name:
M.PliMCI
Dnmt1
MCMT
Gene namesi
Name:DNMT
Synonyms:PLIMCIM
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880381 – 1612DNA (cytosine-5)-methyltransferase PliMCIAdd BLAST1612

Proteomic databases

PRIDEiQ27746

Structurei

3D structure databases

ProteinModelPortaliQ27746
SMRiQ27746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 124DMAP-interactionAdd BLAST75
Domaini743 – 871BAH 1PROSITE-ProRule annotationAdd BLAST129
Domaini967 – 1089BAH 2PROSITE-ProRule annotationAdd BLAST123
Domaini1131 – 1590SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST460

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1142 – 1143S-adenosyl-L-methionine bindingBy similarity2
Regioni1160 – 1161S-adenosyl-L-methionine bindingBy similarity2
Regioni1182 – 1183S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 178Poly-Lys7
Compositional biasi288 – 291Poly-Glu4
Compositional biasi303 – 308Poly-Glu6
Compositional biasi712 – 715Poly-Lys4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri626 – 672CXXC-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

InterProiView protein in InterPro
IPR001025 BAH_dom
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR022702 Cytosine_MeTrfase1_RFD
IPR010506 DMAP1-bd
IPR017198 DNMT1-like
IPR029063 SAM-dependent_MTases
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF01426 BAH, 2 hits
PF06464 DMAP_binding, 2 hits
PF00145 DNA_methylase, 1 hit
PF12047 DNMT1-RFD, 1 hit
PF02008 zf-CXXC, 1 hit
PIRSFiPIRSF037404 DNMT1, 1 hit
PRINTSiPR00105 C5METTRFRASE
SMARTiView protein in SMART
SM00439 BAH, 2 hits
SM01137 DMAP_binding, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 2 hits
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit
PS51058 ZF_CXXC, 1 hit

Sequencei

Sequence statusi: Complete.

Q27746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP
60 70 80 90 100
DIQTKLKGLE DELKDEELTE KGYLNKVQSI LAKFIETCSP VNGDTKEEAS
110 120 130 140 150
SNGKDDEKAE STVANGTTSN GSTTNGSSGS SKANGHTNGG YVQSSSQEET
160 170 180 190 200
GTSQSEEEMD MDTPTSGKGG SKKKKKSKGS GGGDAGKGRK RKVLGDDERD
210 220 230 240 250
GVEKKEGEKK DVEGEEGEEA KEESATPDEK TLRTSKRKRS PKADAKQPSI
260 270 280 290 300
MSMFTKKPAK KEEEKMEESS SMEVDKKEME NGDNGKKEEE EPSGPGGKRI
310 320 330 340 350
KKEEEEEEKA KVEPMSPSRD LRHKANHETA ESKQPPLRCK ECRQLLDDPD
360 370 380 390 400
LKIFPGDPED AREEYITLTD PRLSLLTGDE GDAMSYDERL QHKITNFCVY
410 420 430 440 450
DKSTHICAFD RGMIEKNKEL YFSGYVKPIY DDNPSTEGGI PTKRIGPINE
460 470 480 490 500
WYTTGFDGGH KALIGFSTAF AEYIVMSPSE EYKPFWTAVQ EKIYMSKILI
510 520 530 540 550
EFLQNNVDPV YEDLLTQIET TVPPEGCNRF TEDSLLRHAQ FVVEQVESYD
560 570 580 590 600
DAADRDEVLL ITMPCMRDLI KLAGVTLGKR RAARKAAAVK KDKKPVFTMA
610 620 630 640 650
TVTPLVSHIF DAIFKDQIAD EMKAAASERK KRCGVCEICQ APDCGKCTAC
660 670 680 690 700
KDMIKFGGSG KAKQACKDRR CPNMAVQEAD ENDIDEMDNS SNKENKDEKK
710 720 730 740 750
AKKGRKLETP LKKKKRAKVT WLDEPTEVTE ERAYYKAAML DDEKIEIGDC
760 770 780 790 800
VLIHPDDPTK PLFMARVIYM WQESQGEMMF HAQWFVYGSE TVLGETSDPL
810 820 830 840 850
EVFPIDECQD TYLGSVNAKC TVIYKAPPND WSMIGGIDDP ETDHVIKEDD
860 870 880 890 900
GKTFFYQKWY DPELARFEDY EVLMAPDDIP AHRFCSCCLK NERAQEKETA
910 920 930 940 950
RPGAKLEDQD DSSKVLYSSW HYKGNEFQIG DGVYLLPEVF SFNIKQKVVT
960 970 980 990 1000
KKPVSKKDVD EDLYPENYRK SSEYVKGSNL ECPEPFRIGK IISIYTTKSN
1010 1020 1030 1040 1050
STVRLRVNKM YRPEDTHKGR TAAYQADLNV LYWSEEEAVT ELEVVQGKCS
1060 1070 1080 1090 1100
VVCAEDLNVS TDEYSAGGPH KFYFREAYDS ERKCFEDPPS KSRSTRMKGK
1110 1120 1130 1140 1150
GKGKGKGKAK GKIAVEKEEE KESTETPFNK LKCLDVFAGC GGLSEGFHQA
1160 1170 1180 1190 1200
GICESSWAIE KEEPAAQAYR LNNPGSTVFS DDCNELLRLV MQGEKTSRTG
1210 1220 1230 1240 1250
QKLPQKGDVE LLCGGPPCQG FSGMNRFNSR EYSKFKNSLI SSYLSYCDYY
1260 1270 1280 1290 1300
RPRFFLLENV RNFVSYKKNM VLKLALRCLI RMGYQCTFGI LQAGQYGVPQ
1310 1320 1330 1340 1350
TRRRAIILAA APGEKLPFYP EPLHVFSSRA CSLSVMIGEK KIESNNQWCL
1360 1370 1380 1390 1400
SAPYRTITVR DTMSDLPTIN NGAQKLEISY DGEPQSDFQK KIRGNQYQPI
1410 1420 1430 1440 1450
LRDHICKDMS SLVAARMKHI PLAPGSDWRD LPNIPVTLKD GTTCRKLRYT
1460 1470 1480 1490 1500
HKDKKNGKSS TGALRGVCSC AEGDACDPSD RQFSTLIPWC LPHTGNRHNN
1510 1520 1530 1540 1550
WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS VRECARSQGF
1560 1570 1580 1590 1600
PDTYRFFGSI LDKHRQIGNA VPPPMAAAIG MEIKVCLQTK TKRDQERAAL
1610
EPVKEETEES MD
Length:1,612
Mass (Da):181,219
Last modified:November 1, 1996 - v1
Checksum:i0CB3853FB565CF50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50183 mRNA Translation: CAA90563.1
PIRiJC5210

Similar proteinsi

Entry informationi

Entry nameiDNMT1_PARLI
AccessioniPrimary (citable) accession number: Q27746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health