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Entry version 100 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Carbamoyl phosphate synthetase II

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei564NucleophilePROSITE-ProRule annotation1
Active sitei650PROSITE-ProRule annotation1
Active sitei652PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseImported
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C26.A27

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Carbamoyl phosphate synthetase IIImported (EC:6.3.5.5Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 25HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 677Glutamine amidotransferase type-1InterPro annotationAdd BLAST191
Domaini816 – 1009ATP-graspInterPro annotationAdd BLAST194
Domaini1975 – 2166ATP-graspInterPro annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 420DisorderedSequence analysisAdd BLAST21
Regioni1659 – 1698DisorderedSequence analysisAdd BLAST40
Regioni1760 – 1810DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 99Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi400 – 419PolarSequence analysisAdd BLAST20
Compositional biasi1677 – 1693PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1760 – 1804AcidicSequence analysisAdd BLAST45

Keywords - Domaini

Coiled coilSequence analysis, Glutamine amidotransferasePROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUMV Eukaryota
ENOG410K63F Eukaryota
KOG0370 Eukaryota
COG0458 LUCA
COG0505 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01744 GATase1_CPSase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1030.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.1380, 1 hit
3.40.50.880, 1 hit
3.50.30.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005480 CarbamoylP_synth_lsu_oligo
IPR036897 CarbamoylP_synth_lsu_oligo_sf
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR016185 PreATP-grasp_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02786 CPSase_L_D2, 2 hits
PF02787 CPSase_L_D3, 1 hit
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PF02142 MGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00098 CPSASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01096 CPSase_L_D3, 1 hit
SM01097 CPSase_sm_chain, 1 hit
SM00851 MGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48108 SSF48108, 1 hit
SSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52335 SSF52335, 1 hit
SSF52440 SSF52440, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975 ATP_GRASP, 2 hits
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 2 hits
PS51273 GATASE_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q27732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYISFKYNLY IYIYIYIYIF VLIDFKTVGR LILEDGNEFV GYSVGYEGCK
60 70 80 90 100
GNNSISCHKE YRNIINNDNS KNSNNSFCNN EENNLKDDLL YKNSRLENED
110 120 130 140 150
FIVTGEVIFN TAMVGYPEAL TDPSYFGQIL VLTFPSIGNY GIEKVKHDET
160 170 180 190 200
FGLVQNFESN KIQVQGLVIC EYSKQSYHYN SYITLSEWLK IYKIPCIGGI
210 220 230 240 250
DTRALTKLLR EKGSMLGKIV IYKNRQHINK LYKEINLFDP GNIDTLKYVC
260 270 280 290 300
NHFIRVIKLN NITYNYKNKE EFNYTNEMIT NDSSMEDHDN EINGSISNFN
310 320 330 340 350
NCPSISSFDK SESKNVINHT LLRDKMNLIT SSEEYLKDLH NCNFSNSSDK
360 370 380 390 400
NDSFFKLYGI CEYDKYLIDL EENASFHYNN VDEYGYYDVN KNTNILSNNK
410 420 430 440 450
IEQNNNNENN KNNKNNNNNE VDYIKKDEDN NVNSKVFYSQ YNNNAQNNEH
460 470 480 490 500
TEFNLNNDYS TYIRKKMKNE EFLNLVNKRK VDHKEKIIVI VDCGIKNSII
510 520 530 540 550
KNLIRHGMDL PLTYIIVPYY YNFNHIDYDA VLLSNGPGDP KKCDFLIKNL
560 570 580 590 600
KDSLTKNKII FGICLGNQLL GISLGCDTYK MKYGNRGVNQ PVIQLVDNIC
610 620 630 640 650
YITSQNHGYC LKKKSILKRK ELAISYINAN DKSIEGISHK NGRFYSVQFH
660 670 680 690 700
PEGNNGPEDT SFLFKNFLLD IFNKKKQYRE YLGYNIIYIK KKVLLLGSGG
710 720 730 740 750
LCIGQAGEFD YSGTQAIKSL KECGIYVILV NPNIATVQTS KGLADKVYFL
760 770 780 790 800
PVNCEFVEKI IKKEKPDFIL CTFGGQTALN CALMLDQKKV LKKNNCQCLG
810 820 830 840 850
TSLESIRITE NRTLFAEKLK EINERIAPYG SAKNVNQAID IANKIGYPIL
860 870 880 890 900
VRTTFSLGGL NSSFINNEEE LIEKCNKIFL QTDNEIFIDK SLQGWKEIEY
910 920 930 940 950
ELLRDNKNNC IAICNMENID PLGIHTGDSI VVAPSQTLSN YEYYKFREIA
960 970 980 990 1000
LKVITHLNII GECNIQFGIN PQTGEYCIIE VNARLSRSSA LASKATGYPL
1010 1020 1030 1040 1050
AYISAKIALG YDLISLKNSI TKKTTACFEP SLDYITTKIP RWDLNKFEFA
1060 1070 1080 1090 1100
SNTMNSSMKS VGEVMSIGRT FEESIQKSLR CIDDNYLGFS NTYCIDWDEK
1110 1120 1130 1140 1150
KIIEELKNPS PKRIDAIHQA FHLNMPMDKI HELTHIDYWF LHKFYNIYNL
1160 1170 1180 1190 1200
QNKLKTLKLE QLSFNDLKYF KKHGFSDKQI AHYLSFNTSD NNNNNNNISS
1210 1220 1230 1240 1250
CRVTENDVMK YREKLGLFPH IKVIDTLSAE FPALTNYLYL TYQGQEHDVL
1260 1270 1280 1290 1300
PLNMKRKKIC TLNNKRNANK KKVHVKNHLY NEVVDDKDTQ LHKENNNNNN
1310 1320 1330 1340 1350
MNSGNVENKC KLNKESYGYN NSSNCINTNN INIENNICHD ISINKNIKVT
1360 1370 1380 1390 1400
INNSNNSISN NENVETNLNC VSERAGSHHI YGKEEKSIGS DDTNILSAQN
1410 1420 1430 1440 1450
SNNNFSCNNE NMNKANVDVN VLENDTKKRE DINTTTVFME GQNSVINNKN
1460 1470 1480 1490 1500
KENSSLLKGD EEDIVMVNLK KENNYNSVIN NVDCRKKDMD GKNINDECKT
1510 1520 1530 1540 1550
YKKNKYKDMG LNNNIVDELS NGTSHSTNDH LYLDNFNTSD EEIGNNKNMD
1560 1570 1580 1590 1600
MYLSKEKSIS NKNPGNSYYV VDSVYNNEYK INKMKELIDN ENLNDEYNNN
1610 1620 1630 1640 1650
VNMNCSNYNN ASAFVNGKDR NDNLENDCIE KNMDHTYKHY NRLNNRRSTN
1660 1670 1680 1690 1700
ERMMLMVNNE KESNHEKGHR RNGLNKKNKE KNMEKNKGKN KDKKNYHYVN
1710 1720 1730 1740 1750
HKRNNEYNSN NIESKFNNYV DDINKKEYYE DENDIYYFTH SSQGNNDDLS
1760 1770 1780 1790 1800
NDNYLSSEEL NTDEYDDDYY YDEDEEDDYD DDNDDDDDDD DDGEDEEDND
1810 1820 1830 1840 1850
YYNDDGYDSY NSLSSSRISD VSSVIYSGNE NIFNEKYNDI GFKIIDNRNE
1860 1870 1880 1890 1900
KEKEKKKCFI VLGCGCYRIG SSVEFDWSAI HCVKTIRKLN HKAILINCNP
1910 1920 1930 1940 1950
ETVSTDYDES DRLYFDEITT EVIKFIYNFE NSNGVIIAFG GQTSNNLVFS
1960 1970 1980 1990 2000
LYKNNVNILG SVHKVLIVVK IGINFRTYVI LKIDQPKWNK FTKLSKAIQF
2010 2020 2030 2040 2050
ANEVKFPVLV RPSYVLSGAA MRVVNCFEEL KNFLMKAAIV SKDNPVVISK
2060 2070 2080 2090 2100
FIENAKEIEI DCVSKNGKII NYAISEHVEN AGVHSGDATL ILPAQNIYVE
2110 2120 2130 2140 2150
THRKIKKISE KISKSLNISG PFNIQFICHQ NEIKIIECNL RASRTFPFIS
2160 2170 2180 2190 2200
KALNLNFIDL ATRILMGYDV KPINISLIDL EYTAVKAPIF SFNRLHGSDC
2210 2220 2230 2240 2250
ILGVEMKSTG EVACFGLNKY EALLKSLIAT GMKLPKKSIL ISIKNLNNKL
2260 2270 2280 2290 2300
AFEEPFQLLF LMGFTIYATE GTYDFYSKFL ESFNVNKGSK FHQRLIKVHN
2310 2320 2330 2340 2350
KNAENISPNT TDLIMNHKVE MVINITDTLK TKVSSNGYKI RRLASDFQVP
2360 2370 2380 2390
LITNMKLCSL FIDSLYRKFS RQKERKSFYT IKSYDEYISL V
Length:2,391
Mass (Da):275,677
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i426F3C3E612FEEE2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L32150 Genomic DNA Translation: AAA29522.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18410

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32150 Genomic DNA Translation: AAA29522.1
PIRiT18410

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC26.A27

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IUMV Eukaryota
ENOG410K63F Eukaryota
KOG0370 Eukaryota
COG0458 LUCA
COG0505 LUCA

Family and domain databases

CDDicd01744 GATase1_CPSase, 1 hit
Gene3Di1.10.1030.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.1380, 1 hit
3.40.50.880, 1 hit
3.50.30.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005480 CarbamoylP_synth_lsu_oligo
IPR036897 CarbamoylP_synth_lsu_oligo_sf
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF02786 CPSase_L_D2, 2 hits
PF02787 CPSase_L_D3, 1 hit
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PF02142 MGS, 1 hit
PRINTSiPR00098 CPSASE
SMARTiView protein in SMART
SM01096 CPSase_L_D3, 1 hit
SM01097 CPSase_sm_chain, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF48108 SSF48108, 1 hit
SSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52335 SSF52335, 1 hit
SSF52440 SSF52440, 2 hits
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 2 hits
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 2 hits
PS51273 GATASE_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ27732_PLAFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27732
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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