Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase, cytosolic

Gene

PGKB

Organism
Leishmania mexicana
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, cytosolic (GAPC), Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (GAPG)
  2. Phosphoglycerate kinase, glycosomal (PGKC), Phosphoglycerate kinase, cytosolic (PGKB)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (PYK)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei132SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei220ATPBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, cytosolic (EC:2.7.2.3)
Alternative name(s):
Phosphoglycerate kinase B
Gene namesi
Name:PGKB
OrganismiLeishmania mexicana
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458551 – 417Phosphoglycerate kinase, cytosolicAdd BLAST417

Proteomic databases

PRIDEiQ27684

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ27684
SMRiQ27684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni62 – 65Substrate bindingBy similarity4

Domaini

This cytosolic PGK lacks a C-terminal extension of 38 AA which is present in the glycosomal isoenzyme.

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR027250 Pgk_euglenozoa
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PIRSF500126 Pgk_euglenozoa, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q27684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVLKKSID DVALKDKKVL IRVDFNVPVK NGEITNDFRI RSALPTIQKV
60 70 80 90 100
LKEGGSCILM SHLGRPKGAR MSDPKPEKGV RGYEEAATLR PVAARLSELL
110 120 130 140 150
EEKVAKAPDC LNASIYVSKL KRGDVLLLEN VRFYTEEGSK KEEEADAMAK
160 170 180 190 200
VLASYADLYV SDAFGTAHRD SATMTGIPKV LGSGYAGYLM EKEINYFSRV
210 220 230 240 250
LNNPPRPLVA IVGGAKVSDK IELLDNMLGR INYLVIGGAM AYTFQKAQGR
260 270 280 290 300
KIGISMCEED KLDLAKSLLK KAQERGVQVL LPVDHVCNKE FKAVDSPLVT
310 320 330 340 350
EDVDVPDGYM ALDIGPKTIH MYEEVIGRCK SAIWNGPMGV FEMPCISKGT
360 370 380 390 400
FAVAKAMGTG TQKDGLLSII GGGDTASAAE LSARAKNMSH VSTGGGASLE
410
LLEGKTLPGV AILTDKQ
Length:417
Mass (Da):44,968
Last modified:November 1, 1996 - v1
Checksum:iF79168E2C90C166D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98486 Genomic DNA Translation: CAA67112.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98486 Genomic DNA Translation: CAA67112.1

3D structure databases

ProteinModelPortaliQ27684
SMRiQ27684
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ27684

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR027250 Pgk_euglenozoa
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PIRSF500126 Pgk_euglenozoa, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGKB_LEIME
AccessioniPrimary (citable) accession number: Q27684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again