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Entry version 98 (07 Apr 2021)
Sequence version 2 (09 Jul 2014)
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Protein

ATP-dependent 6-phosphofructokinase

Gene

PPi-PFK

Organism
Entamoeba histolytica
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.UniRule annotation1 Publication

Caution

Was originally thought to be a PPi-dependent phosphofructokinase (PubMed:8645233), but it has later been shown that the enzyme does not possess PPi-dependent activity and instead is an ATP-dependent phosphofructokinase (PubMed:11262402).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by nucleoside triphosphates. Inhibited by phosphoenolpyruvate. EDTA and biphosphonates play the role of inhibitors of kinase activity.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.12 mM for ATP
  2. KM=0.067 mM for GTP
  3. KM=0.136 mM for ITP
  4. KM=1.93 mM for UTP
  5. KM=3.6 mM for CTP
  6. KM=3.8 mM for fructose 6-phosphate

    pH dependencei

    Optimum pH is 6-7.

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

    This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. Phosphotransferase, Phosphotransferase (HXK1), Phosphotransferase, Phosphotransferase (HXK-2), Phosphotransferase (CL6EHI_098560), Phosphotransferase (HXK2), Phosphotransferase, Phosphotransferase (CL6EHI_098290), Phosphotransferase (HXK-1)
    2. Glucose-6-phosphate isomerase (G6PI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (CL6EHI_047730)
    3. Phosphofructokinase, putative (EHI_163630), ATP-dependent 6-phosphofructokinase (CL6EHI_103590), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, Phosphofructokinase putative (CL6EHI_163630), Phosphofructokinase putative (CL6EHI_187040), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (EHI_000730), Phosphofructokinase, putative (EHI_187040), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (CL6EHI_000730), ATP-dependent 6-phosphofructokinase (PPi-PFK)
    4. no protein annotated in this organism
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90ATP; via amide nitrogenUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi181Magnesium; catalyticUniRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei182Important for substrate specificity; cannot use PPi as phosphoryl donorUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei211Proton acceptorUniRule annotation1
    Binding sitei307SubstrateUniRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi155 – 156ATPUniRule annotation2
    Nucleotide bindingi180 – 183ATPUniRule annotation4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAllosteric enzyme, Kinase, Transferase
    Biological processGlycolysis
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.90, 2080

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00182

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
    Short name:
    ATP-PFKUniRule annotation
    Short name:
    PhosphofructokinaseUniRule annotation
    Alternative name(s):
    PhosphohexokinaseUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PPi-PFK
    ORF Names:EHI_103590
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolytica
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaArchamoebaeMastigamoebidaEntamoebidaeEntamoeba
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001926 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

    Organism-specific databases

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    AmoebaDB:EHI5A_077230
    AmoebaDB:EHI7A_062050
    AmoebaDB:EHI8A_049590
    AmoebaDB:EHI_103590
    AmoebaDB:KM1_109080

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004230211 – 436ATP-dependent 6-phosphofructokinaseAdd BLAST436

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer. Aggregates to a homotetramer after activation by ATP.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    5759.rna_EHI_103590-1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q27651

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 211Substrate bindingUniRule annotation3
    Regioni254 – 256Substrate bindingUniRule annotation3
    Regioni362 – 365Substrate bindingUniRule annotation4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2440, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_020655_7_4_1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WFAKQFA

    Family and domain databases

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01981, Phosphofructokinase_II_X, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR022953, ATP_PFK
    IPR000023, Phosphofructokinase_dom
    IPR035966, PKF_sf
    IPR012004, PyroP-dep_PFK_TP0108

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00365, PFK, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000534, PPi_PFK_TP0108, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00476, PHFRCTKINASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53784, SSF53784, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q27651-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSVKRRDHIL IPKNPDAPLP SLKIEEVGEC TIDNIYASPE PFVNGMTMKL
    60 70 80 90 100
    SAVKNHGIER DSGEVELAGP MEKIFYNPET TKVAIVTCGG LCPGLNNVIR
    110 120 130 140 150
    GLVLNLYNRY HVNNIFGLRW GYEGLVPELS EVQRLTPEIV SDIHQKGGSI
    160 170 180 190 200
    LGTSRGAQSP EVMAQFLIDN NFNILFTLGG DGTLRGANAI NKELRRRKVP
    210 220 230 240 250
    ITVVGIPKTI DNDICYTDST FGFQTAVGLS QEAINAVHSE AKSAKNGIGI
    260 270 280 290 300
    VRLMGRDAGF IALYASLANG DANLVLIPEI DIPITQICEF VGKRIMSKGH
    310 320 330 340 350
    VVIVVAEGAL QNQKPKDLDL GTDKSGNILH WDSINYLRDS ITKYLKSIGI
    360 370 380 390 400
    EEHTIKFVDP SYMIRSAPCS AADAHFCMCL ANAAVHVAMA GKTGLVICHH
    410 420 430
    HNNFVSVPID RTSYYIKRVN TDGPLYTMMT AIEKPK
    Length:436
    Mass (Da):47,670
    Last modified:July 9, 2014 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFD2E9639DAA1138
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA92671 differs from that shown. Reason: Frameshift.Curated
    The sequence AAA92671 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109R → A in CAA57659 (PubMed:8645233).Curated1
    Sequence conflicti430T → S in CAA57659 (PubMed:8645233).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X82173 mRNA Translation: CAA57659.1
    DS571158 Genomic DNA Translation: EAL47987.1
    U12513 Genomic DNA Translation: AAA92671.1 Sequence problems.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S49458

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_653373.1, XM_648281.1

    Genome annotation databases

    Ensembl protists genome annotation project

    More...
    EnsemblProtistsi
    rna_EHI_103590-1; rna_EHI_103590-1; EHI_103590

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3407680

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ehi:EHI_103590

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X82173 mRNA Translation: CAA57659.1
    DS571158 Genomic DNA Translation: EAL47987.1
    U12513 Genomic DNA Translation: AAA92671.1 Sequence problems.
    PIRiS49458
    RefSeqiXP_653373.1, XM_648281.1

    3D structure databases

    SMRiQ27651
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi5759.rna_EHI_103590-1

    Genome annotation databases

    EnsemblProtistsirna_EHI_103590-1; rna_EHI_103590-1; EHI_103590
    GeneIDi3407680
    KEGGiehi:EHI_103590

    Organism-specific databases

    VEuPathDBiAmoebaDB:EHI5A_077230
    AmoebaDB:EHI7A_062050
    AmoebaDB:EHI8A_049590
    AmoebaDB:EHI_103590
    AmoebaDB:KM1_109080

    Phylogenomic databases

    eggNOGiKOG2440, Eukaryota
    HOGENOMiCLU_020655_7_4_1
    OMAiWFAKQFA

    Enzyme and pathway databases

    UniPathwayiUPA00109;UER00182
    BRENDAi2.7.1.90, 2080

    Family and domain databases

    HAMAPiMF_01981, Phosphofructokinase_II_X, 1 hit
    InterProiView protein in InterPro
    IPR022953, ATP_PFK
    IPR000023, Phosphofructokinase_dom
    IPR035966, PKF_sf
    IPR012004, PyroP-dep_PFK_TP0108
    PfamiView protein in Pfam
    PF00365, PFK, 1 hit
    PIRSFiPIRSF000534, PPi_PFK_TP0108, 1 hit
    PRINTSiPR00476, PHFRCTKINASE
    SUPFAMiSSF53784, SSF53784, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPFKA_ENTHI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27651
    Secondary accession number(s): C4LVK3, Q24812
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
    Last sequence update: July 9, 2014
    Last modified: April 7, 2021
    This is version 98 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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