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Entry version 106 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Phosphotransferase

Gene

HXK1

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.ARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Phosphotransferase, Phosphotransferase (HXK1), Phosphotransferase, Phosphotransferase (HXK-2), Phosphotransferase (CL6EHI_098560), Phosphotransferase (HXK2), Phosphotransferase, Phosphotransferase (CL6EHI_098290), Phosphotransferase (HXK-1)
  2. Glucose-6-phosphate isomerase (G6PI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (CL6EHI_047730)
  3. Phosphofructokinase, putative (EHI_163630), ATP-dependent 6-phosphofructokinase (CL6EHI_103590), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, Phosphofructokinase putative (CL6EHI_163630), Phosphofructokinase putative (CL6EHI_187040), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (EHI_000730), Phosphofructokinase, putative (EHI_187040), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (CL6EHI_000730), ATP-dependent 6-phosphofructokinase (PPi-PFK)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImportedARBA annotation, Transferase
Biological processGlycolysisUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q27647

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00180

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PhosphotransferaseUniRule annotation (EC:2.7.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HXK1Imported
ORF Names:EHI_098290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolyticaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaArchamoebaeMastigamoebidaEntamoebidaeEntamoeba
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001926 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
AmoebaDB:EHI5A_039090
AmoebaDB:EHI5A_083040
AmoebaDB:EHI7A_052510
AmoebaDB:EHI_098290
AmoebaDB:KM1_095060

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q27647

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 191Hexokinase_1InterPro annotationAdd BLAST190
Domaini198 – 439Hexokinase_2InterPro annotationAdd BLAST242

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014393_5_3_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FDRKHLH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043129, ATPase_NBD
IPR001312, Hexokinase
IPR022673, Hexokinase_C
IPR022672, Hexokinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR19443, PTHR19443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00349, Hexokinase_1, 1 hit
PF03727, Hexokinase_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51748, HEXOKINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q27647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEIIDQFAI DKEKMEIIVS KLLEEMENGL QDKPSTLQML PTYAPIPTGK
60 70 80 90 100
EVGTFMGIDV GGTNLRVLLL EIPEPGVRGE LKSVECIMPK TSTTVDQFFG
110 120 130 140 150
FIAQKIKEFV ENNNLKEKEI KAGLTFSFAV EQIAIDKGIQ QSWSKGWDVK
160 170 180 190 200
ESIGKDIVEI FHNQLAKINV NNIRIVAFIN DTVGTFANLA YDDASCGMGL
210 220 230 240 250
IFGTGTNGCY IEKTSNFAAS KLKSVYKEDY MIVNTEWGGL QFPELGLNRF
260 270 280 290 300
DDMINDVSVN KDQQRYEKMI SGIYMGWLAR LAIRELIEKK VIFERYADAE
310 320 330 340 350
VFSNSPDDTQ FNDKKKYSSR HTEIVEDTSP ELSRVDTILK SLGVNDSTLE
360 370 380 390 400
ERKILKAITE AVVKRAAYLS AAATVALYRK MVPYMKERTT AGIDGTVYEK
410 420 430 440
SVPFKRFYLE AIRLLQPKEN FTCQLSKDGS GLGAVIVAAA VACKH
Length:445
Mass (Da):49,830
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5B888693A00826D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK418850 mRNA Translation: BAN37591.1
X82197 mRNA Translation: CAA57681.1
DS571169 Genomic DNA Translation: EAL48234.1

NCBI Reference Sequences

More...
RefSeqi
XP_653620.1, XM_648528.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
GAT93385; GAT93385; CL6EHI_098290
rna_EHI_098290-1; rna_EHI_098290-1; EHI_098290

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3407925

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ehi:EHI_098290

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK418850 mRNA Translation: BAN37591.1
X82197 mRNA Translation: CAA57681.1
DS571169 Genomic DNA Translation: EAL48234.1
RefSeqiXP_653620.1, XM_648528.2

3D structure databases

SMRiQ27647
ModBaseiSearch...

Genome annotation databases

EnsemblProtistsiGAT93385; GAT93385; CL6EHI_098290
rna_EHI_098290-1; rna_EHI_098290-1; EHI_098290
GeneIDi3407925
KEGGiehi:EHI_098290

Organism-specific databases

VEuPathDBiAmoebaDB:EHI5A_039090
AmoebaDB:EHI5A_083040
AmoebaDB:EHI7A_052510
AmoebaDB:EHI_098290
AmoebaDB:KM1_095060

Phylogenomic databases

HOGENOMiCLU_014393_5_3_1
OMAiFDRKHLH

Enzyme and pathway databases

UniPathwayiUPA00109;UER00180
SABIO-RKiQ27647

Family and domain databases

InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR001312, Hexokinase
IPR022673, Hexokinase_C
IPR022672, Hexokinase_N
PANTHERiPTHR19443, PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349, Hexokinase_1, 1 hit
PF03727, Hexokinase_2, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS51748, HEXOKINASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ27647_ENTHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q27647
Secondary accession number(s): A0A175JIJ4, C4LXB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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